Single mutants |
APP−/− | Viable and fertile | Zheng et al. |
| Reduced body weight | Müller et al. |
| Reduced grip strength | Li et al. |
| Reduced locomotor activity |
| Alterations in sensorimotor development | Tremml et al. |
| Commissure defects | Magara et al. |
| Hypersensitivity to epileptic seizures | Steinbach et al. |
APLP1−/− | Viable and fertile | This paper |
| Reduced body weight |
APLP2−/− | Viable and fertile | von Koch et al. |
| No apparent abnormalities |
Double mutants |
APLP2−/−, APP−/− | Perinatally lethal | This paper |
| No histopathological anomalies | von Koch et al. |
APLP2−/−, APLP1−/− | Perinatally lethal | This paper |
| No histopathological anomalies |
APLP1−/−, APP−/− | Viable and fertile | This paper |
| Reduced body weight |
APLP1−/−, APP−/−, APLP2+/− | Perinatally lethal | This paper |
| No histopathological anomalies |