Constitutive Endocytosis of GABAA Receptors by an Association with the Adaptin AP2 Complex Modulates Inhibitory Synaptic Currents in Hippocampal Neurons

Josef T. Kittler; Patrick Delmas; Jasmina N. Jovanovic; David A. Brown; Trevor G. Smart; Stephen J. Moss

doi:10.1523/JNEUROSCI.20-21-07972.2000

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.20-21-07972.2000

PubMed

11050117

Published By

Society for Neuroscience

History

Received May 25, 2000
Revision received August 2, 2000
Accepted August 16, 2000
First published November 1, 2000.

Version of record published November 1, 2000.

Author Information

Josef T. Kittler1,
Patrick Delmas2,
Jasmina N. Jovanovic1,
David A. Brown2,
Trevor G. Smart3, and
Stephen J. Moss1

¹Department of Pharmacology, Medical Research Council Laboratory of Molecular Cell Biology and
² Wellcome Laboratory for Molecular Pharmacology, University College London, London WC1E 6BT, United Kingdom, and
³Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, United Kingdom

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Author contributions

Disclosures

Received May 25, 2000.
Revision received August 2, 2000.
Accepted August 16, 2000.

This work was supported by the Medical Research Council and the Wellcome Trust. We thank Dr. Harvey McMahon for the dynamin peptide and Dr. Werner Sieghart for the GABA_A receptor β3 antibody. We thank Drs. Andres Couve, Fiona Bedford, Mark Marsh, and Alberto Ramos for helpful discussions.
Correspondence should be addressed to Dr. Stephen J. Moss, Medical Research Council Laboratory of Molecular Cell Biology, University College, Gower Street, London WC1E 6BT, UK. E-mail:steve.moss{at}ucl.ac.uk.

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	Abstract	Full	Pdf
Oct 2000	221	218	280
Nov 2000	69	229	157
Dec 2000	7	45	38
Total 2000	297	492	475
Jan 2001	7	91	54
Feb 2001	3	62	35
Mar 2001	9	55	38
Apr 2001	7	53	28
May 2001	4	45	29
Jun 2001	5	41	20
Jul 2001	4	38	22
Aug 2001	2	22	21
Sep 2001	5	48	30
Oct 2001	2	35	21
Nov 2001	8	45	45
Dec 2001	5	27	16
Total 2001	61	562	359
Jan 2002	2	45	35
Feb 2002	2	40	29
Mar 2002	3	60	44
Apr 2002	2	31	30
May 2002	2	33	41
Jun 2002	2	23	23
Jul 2002	0	26	27
Aug 2002	3	27	31
Sep 2002	0	20	25
Oct 2002	4	32	21
Nov 2002	1	33	43
Dec 2002	0	22	18
Total 2002	21	392	367
Jan 2003	1	28	34
Feb 2003	1	26	36
Mar 2003	1	22	27
Apr 2003	0	28	32
May 2003	2	46	39
Jun 2003	1	40	36
Jul 2003	5	51	30
Aug 2003	10	40	27
Sep 2003	12	46	37
Oct 2003	12	27	21
Nov 2003	23	30	30
Dec 2003	17	41	22
Total 2003	85	425	371
Jan 2004	21	24	12
Feb 2004	8	49	43
Mar 2004	25	58	32
Apr 2004	16	42	17
May 2004	28	56	29
Jun 2004	17	45	23
Jul 2004	17	34	21
Aug 2004	44	52	16
Sep 2004	48	53	16
Oct 2004	38	60	26
Nov 2004	17	52	35
Dec 2004	13	31	23
Total 2004	292	556	293
Jan 2005	25	46	36
Feb 2005	14	49	21
Mar 2005	20	54	45
Apr 2005	7	31	15
May 2005	12	36	16
Jun 2005	24	63	32
Jul 2005	19	58	23
Aug 2005	12	42	21
Sep 2005	5	38	23
Oct 2005	15	47	32
Nov 2005	23	59	34
Dec 2005	20	41	16
Total 2005	196	564	314
Jan 2006	24	51	22
Feb 2006	15	45	28
Mar 2006	21	58	26
Apr 2006	15	40	19
May 2006	29	46	28
Jun 2006	8	27	21
Jul 2006	9	28	23
Aug 2006	8	30	20
Sep 2006	4	24	15
Oct 2006	14	43	26
Nov 2006	14	34	37
Dec 2006	10	28	21
Total 2006	171	454	286
Jan 2007	14	28	22
Feb 2007	6	42	37
Mar 2007	12	28	28
Apr 2007	7	26	12
May 2007	8	29	25
Jun 2007	7	24	14
Jul 2007	11	29	23
Aug 2007	9	29	15
Sep 2007	6	19	16
Oct 2007	10	37	28
Nov 2007	9	28	23
Dec 2007	6	25	23
Total 2007	105	344	266
Jan 2008	4	20	14
Feb 2008	9	34	24
Mar 2008	18	28	32
Apr 2008	12	29	29
May 2008	9	20	15
Jun 2008	15	34	26
Jul 2008	13	31	19
Aug 2008	16	38	24
Sep 2008	33	29	20
Oct 2008	30	22	30
Nov 2008	27	28	16
Dec 2008	5	13	14
Total 2008	191	326	263
Jan 2009	5	16	14
Feb 2009	13	31	10
Mar 2009	12	23	21
Apr 2009	21	16	16
May 2009	14	22	15
Jun 2009	13	18	13
Jul 2009	19	24	27
Aug 2009	7	23	16
Sep 2009	13	36	31
Oct 2009	17	35	25
Nov 2009	14	20	25
Dec 2009	15	20	16
Total 2009	163	284	229
Jan 2010	9	18	16
Feb 2010	7	21	14
Mar 2010	17	22	37
Apr 2010	9	21	20
May 2010	19	21	18
Jun 2010	2	29	23
Jul 2010	12	26	28
Aug 2010	15	31	23
Sep 2010	7	25	16
Oct 2010	7	28	21
Nov 2010	16	27	31
Dec 2010	16	23	29
Total 2010	136	292	276
Jan 2011	13	23	25
Feb 2011	10	28	12
Mar 2011	19	32	22
Apr 2011	11	34	30
May 2011	10	22	30
Jun 2011	15	22	33
Jul 2011	1	17	13
Aug 2011	12	15	24
Sep 2011	14	43	33
Oct 2011	21	18	23
Nov 2011	14	28	49
Dec 2011	11	29	41
Total 2011	151	311	335
Jan 2012	12	20	23
Feb 2012	18	29	31
Mar 2012	20	22	29
Apr 2012	13	20	32
May 2012	22	26	34
Jun 2012	15	24	17
Jul 2012	20	44	47
Aug 2012	8	26	24
Sep 2012	9	14	22
Oct 2012	17	25	41
Nov 2012	29	31	40
Dec 2012	17	9	26
Total 2012	200	290	366
Jan 2013	22	29	33
Feb 2013	24	13	43
Mar 2013	19	27	45
Apr 2013	12	6	47
May 2013	7	18	54
Jun 2013	16	17	30
Jul 2013	11	14	25
Aug 2013	5	8	11
Sep 2013	3	15	26
Oct 2013	17	15	30
Nov 2013	17	9	35
Dec 2013	19	9	25
Total 2013	172	180	404
Jan 2014	9	18	30
Feb 2014	16	14	39
Mar 2014	14	23	28
Apr 2014	22	18	20
May 2014	21	15	30
Jun 2014	11	13	23
Jul 2014	17	18	28
Aug 2014	5	8	18
Sep 2014	15	9	21
Oct 2014	9	19	16
Nov 2014	14	15	27
Dec 2014	10	9	20
Total 2014	163	179	300
Jan 2015	11	19	26
Feb 2015	14	14	41
Mar 2015	17	14	18
Apr 2015	11	12	21
May 2015	10	20	31
Jun 2015	13	28	16
Jul 2015	11	16	19
Aug 2015	5	8	20
Sep 2015	18	7	9
Oct 2015	6	20	26
Nov 2015	15	14	20
Dec 2015	5	11	14
Total 2015	136	183	261
Jan 2016	17	16	23
Feb 2016	16	18	20
Mar 2016	10	12	21
Apr 2016	13	11	14
May 2016	22	19	18
Jun 2016	19	19	17
Jul 2016	11	13	9
Aug 2016	16	6	6
Sep 2016	16	9	12
Oct 2016	14	15	16
Nov 2016	5	11	9
Dec 2016	3	17	3
Total 2016	162	166	168
Jan 2017	5	16	17
Feb 2017	3	6	4
Mar 2017	5	21	9
Apr 2017	7	13	3
May 2017	12	69	4
Jun 2017	6	16	4
Jul 2017	6	19	9
Aug 2017	9	8	9
Sep 2017	6	29	10
Oct 2017	6	16	5
Nov 2017	7	22	3
Dec 2017	4	17	11
Total 2017	76	252	88
Jan 2018	2	13	6
Feb 2018	6	16	4
Mar 2018	15	30	15
Apr 2018	2	23	8
May 2018	4	31	6
Jun 2018	4	32	9
Jul 2018	3	22	6
Aug 2018	4	22	6
Sep 2018	4	32	9
Oct 2018	2	15	2
Nov 2018	5	20	11
Dec 2018	2	26	12
Total 2018	53	282	94
Jan 2019	3	17	6
Feb 2019	6	17	12
Mar 2019	4	26	15
Apr 2019	4	26	5
May 2019	5	27	9
Jun 2019	4	21	6
Jul 2019	5	23	13
Aug 2019	6	48	6
Sep 2019	4	57	14
Oct 2019	5	59	9
Nov 2019	4	30	14
Dec 2019	4	24	10
Total 2019	54	375	119
Jan 2020	4	40	9
Feb 2020	2	29	8
Mar 2020	4	35	7
Apr 2020	3	12	4
May 2020	3	40	7
Jun 2020	2	40	50
Jul 2020	9	18	11
Aug 2020	5	18	12
Sep 2020	7	27	8
Oct 2020	2	38	12
Nov 2020	7	26	10
Dec 2020	7	22	10
Total 2020	55	345	148
Jan 2021	7	52	13
Feb 2021	2	41	22
Total 2021	9	93	35
Total	2949	7347	5817