Article Figures & Data
Figures
- Fig. 1.
Reconstructions of coronal sections of the largest (striped) and smallest (black) lesions in the rats with radio-frequency lesions of the hippocampus (H-RF), ibotenic acid lesions of the hippocampus (H-IBO), ibotenic acid lesions of the cortex dorsal to the hippocampus (CTX), and radio-frequency lesions of the fornix (FX). Each series of sections progresses (left to right) from anterior to posterior levels. Numbers represent the distance in millimeters posterior to bregma.
- Fig. 2.
Percent preference for the novel object across 30 sec of cumulative object exploration (CON group; n= 16). The data are from the test phase (all delays combined). Preference for the novel object first increased and then gradually decreased during the 30 sec test period. Error bars indicate SEM.
- Fig. 3.
Mean time that the CON group spent at the novel and familiar objects on each visit (all delays combined). Visits to the novel object lasted longer than visits to the familiar object. Error bars indicate SEM.
- Fig. 4.
Percent preference (30 sec time bin) for the novel object across five delays for two control groups (CONand CTX) and two groups with radio-frequency or ibotenate lesions of the hippocampus (H-RF andH-IBO).
- Fig. 5.
Percent preference (30 sec time bin) for the novel object across five delays for two control groups (CON+CTX, combined) and the group with fornix lesions (FX).
Tables
AP ML DV H-IBO −2.4 ±1.0 −3.5 −3.2 ±1.4 −3.2, −2.3 −3.2 ±3.0 −2.7 −4.0 ±2.5 −2.8, −1.8 −4.0 ±3.7 −2.7 −4.8 ±4.9 −7.2, −6.4 −4.8 ±4.3 −7.7, −7.1, −3.5 −5.4 ±4.2 −4.4, −3.9 −5.4 ±5.0 −6.6, −5.9, −5.2, −4.5 H-RF −2.4 ±1.0 −3.5 −3.2 ±1.4 −2.7 −3.2 ±3.0 −2.7 −4.0 ±2.5 −2.3 −4.0 ±3.7 −2.7 −4.8 ±4.9 −6.8 −4.8 ±4.3 −7.4, −3.5 5.4 ±4.2 −4.2 −5.4 ±5.0 −6.5, −5.5, −4.5 FX −0.1 −1.7 −4.71-a −0.5 −1.54 −4.231-a −0.5 −2.05 −5.641-a −1.5 ±1.8 −3.8 All numbers are in millimeters and relative to bregma. AP, Anteroposterior; ML, mediolateral; DV, dorsoventral planes. ± in the ML column indicates right and left targets. The coordinates for the CTX group were identical to the H-IBO group except that the DV coordinates were 1.5 mm more dorsal than the most dorsal H-IBO target at each AP/ML location.
↵F1-a The target was approached at a 20° angle from the right.
Task Reference Humans Monkeys Rats DNMS Squire et al., 1988 Zola-Morgan et al., 1992 Mumby et al., 1992 Alvarez et al., 1995 Mumby et al., 1995 Beason-Held et al., 1999 Clark et al., 2000 Zola et al., 2000 VPC McKee and Squire, 1993 Zola et al., 2000 Present study DNMS, Trial-unique delayed nonmatching to sample with objects; VPC, visual paired comparison.
