The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease

Mona Thiruchelvam; Eric K. Richfield; Raymond B. Baggs; Arnold W. Tank; Deborah A. Cory-Slechta

doi:10.1523/JNEUROSCI.20-24-09207.2000

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.20-24-09207.2000

PubMed

11124998

Published By

Society for Neuroscience

History

Received August 22, 2000
Revision received September 25, 2000
Accepted September 27, 2000
First published December 15, 2000.

Version of record published December 15, 2000.

Author Information

Mona Thiruchelvam1,
Eric K. Richfield2,6,
Raymond B. Baggs5,6,
Arnold W. Tank3, and
Deborah A. Cory-Slechta4,6

¹Interdepartmental Program in Neuroscience, Departments of
²Pathology and Laboratory Medicine,
³Pharmacology and Physiology, and
⁴Environmental Medicine, the
⁵Division of Laboratory Animal Medicine, and the
⁶National Institute of Environmental Health Sciences Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

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Author contributions

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Disclosures

Received August 22, 2000.
Revision received September 25, 2000.
Accepted September 27, 2000.

This work was supported in part by National Institute of Environmental Health Sciences Grants ES01247, ES05017, and ES05903 to D.A.C.-S., Department of Defense Grant DMD17-98-1-8628 to E.K.R., and National Institute on Drug Abuse Grant DA05014 and Tobacco Research Council Grant STRC0481 to A.W.T. Special thanks go to Dr. Kenneth Olden. We also thank Brian Rahm and Carol Sterling for technical assistance.
Correspondence should be addressed to Dr. Deborah A. Cory-Slechta, Department of Environmental Medicine, Box Environmental Health Sciences Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642. E-mail:deborah_slechta{at}urmc.rochester.edu.

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	Abstract	Full	Pdf
Dec 2000	52	63	24
Total 2000	52	63	24
Jan 2001	430	641	254
Feb 2001	52	107	54
Mar 2001	25	88	46
Apr 2001	32	100	47
May 2001	28	86	37
Jun 2001	16	71	33
Jul 2001	21	40	23
Aug 2001	16	50	18
Sep 2001	7	42	15
Oct 2001	26	37	20
Nov 2001	11	55	18
Dec 2001	8	36	11
Total 2001	672	1353	576
Jan 2002	6	49	44
Feb 2002	13	48	32
Mar 2002	14	66	39
Apr 2002	15	56	47
May 2002	14	36	33
Jun 2002	10	36	38
Jul 2002	2	24	28
Aug 2002	4	27	29
Sep 2002	14	32	31
Oct 2002	20	42	49
Nov 2002	15	29	27
Dec 2002	9	25	24
Total 2002	136	470	421
Jan 2003	8	23	42
Feb 2003	17	45	51
Mar 2003	12	23	26
Apr 2003	14	49	35
May 2003	7	43	41
Jun 2003	13	23	24
Jul 2003	19	49	43
Aug 2003	14	17	18
Sep 2003	18	34	21
Oct 2003	30	54	24
Nov 2003	44	57	45
Dec 2003	25	44	20
Total 2003	221	461	390
Jan 2004	37	94	45
Feb 2004	25	54	45
Mar 2004	44	68	48
Apr 2004	46	62	27
May 2004	42	57	33
Jun 2004	37	42	12
Jul 2004	29	58	35
Aug 2004	44	58	44
Sep 2004	24	52	27
Oct 2004	25	54	27
Nov 2004	30	74	30
Dec 2004	50	71	23
Total 2004	433	744	396
Jan 2005	39	48	23
Feb 2005	26	62	51
Mar 2005	33	64	67
Apr 2005	12	72	27
May 2005	25	57	35
Jun 2005	25	43	43
Jul 2005	26	46	17
Aug 2005	18	41	14
Sep 2005	19	30	22
Oct 2005	36	64	23
Nov 2005	24	44	25
Dec 2005	17	45	18
Total 2005	300	616	365
Jan 2006	12	95	26
Feb 2006	22	54	21
Mar 2006	12	70	24
Apr 2006	14	56	28
May 2006	11	39	15
Jun 2006	6	34	20
Jul 2006	20	25	22
Aug 2006	13	36	20
Sep 2006	15	37	25
Oct 2006	15	55	24
Nov 2006	17	75	40
Dec 2006	7	54	23
Total 2006	164	630	288
Jan 2007	22	45	48
Feb 2007	36	56	24
Mar 2007	44	108	46
Apr 2007	23	51	27
May 2007	21	56	31
Jun 2007	18	52	19
Jul 2007	10	34	16
Aug 2007	17	48	22
Sep 2007	24	84	34
Oct 2007	18	70	27
Nov 2007	18	71	30
Dec 2007	18	76	16
Total 2007	269	751	340
Jan 2008	34	79	33
Feb 2008	19	71	34
Mar 2008	31	85	29
Apr 2008	32	118	48
May 2008	22	63	22
Jun 2008	30	118	32
Jul 2008	32	80	20
Aug 2008	15	50	11
Sep 2008	37	78	21
Oct 2008	29	49	33
Nov 2008	43	51	28
Dec 2008	28	61	22
Total 2008	352	903	333
Jan 2009	24	60	13
Feb 2009	31	50	23
Mar 2009	42	83	45
Apr 2009	30	62	29
May 2009	18	52	19
Jun 2009	20	48	19
Jul 2009	29	79	18
Aug 2009	16	56	20
Sep 2009	19	35	10
Oct 2009	37	78	19
Nov 2009	33	59	34
Dec 2009	29	43	30
Total 2009	328	705	279
Jan 2010	18	39	24
Feb 2010	20	51	22
Mar 2010	27	78	40
Apr 2010	19	50	26
May 2010	16	58	26
Jun 2010	5	46	23
Jul 2010	7	43	18
Aug 2010	20	63	24
Sep 2010	19	67	32
Oct 2010	21	50	27
Nov 2010	40	65	40
Dec 2010	24	31	19
Total 2010	236	641	321
Jan 2011	16	33	11
Feb 2011	17	30	19
Mar 2011	43	64	30
Apr 2011	24	57	22
May 2011	38	34	23
Jun 2011	25	52	23
Jul 2011	12	33	29
Aug 2011	15	30	25
Sep 2011	20	70	35
Oct 2011	27	69	29
Nov 2011	26	79	34
Dec 2011	21	24	24
Total 2011	284	575	304
Jan 2012	22	27	21
Feb 2012	32	38	30
Mar 2012	47	41	28
Apr 2012	30	22	21
May 2012	23	21	10
Jun 2012	19	20	22
Jul 2012	40	25	22
Aug 2012	19	17	18
Sep 2012	12	25	30
Oct 2012	41	33	19
Nov 2012	38	53	33
Dec 2012	37	17	15
Total 2012	360	339	269
Jan 2013	31	41	29
Feb 2013	29	44	20
Mar 2013	43	37	29
Apr 2013	23	22	14
May 2013	25	30	25
Jun 2013	18	9	17
Jul 2013	19	23	11
Aug 2013	20	12	31
Sep 2013	17	15	47
Oct 2013	27	20	30
Nov 2013	34	27	28
Dec 2013	42	19	73
Total 2013	328	299	354
Jan 2014	14	33	60
Feb 2014	20	15	45
Mar 2014	42	28	55
Apr 2014	24	12	54
May 2014	20	11	36
Jun 2014	33	21	30
Jul 2014	42	22	52
Aug 2014	13	21	39
Sep 2014	39	14	36
Oct 2014	21	18	58
Nov 2014	14	14	64
Dec 2014	22	19	51
Total 2014	304	228	580
Jan 2015	11	14	23
Feb 2015	35	36	34
Mar 2015	27	49	23
Apr 2015	12	23	8
May 2015	26	30	9
Jun 2015	12	13	29
Jul 2015	12	17	24
Aug 2015	15	7	16
Sep 2015	10	27	21
Oct 2015	60	17	20
Nov 2015	19	20	13
Dec 2015	19	32	7
Total 2015	258	285	227
Jan 2016	66	28	18
Feb 2016	22	33	21
Mar 2016	41	31	26
Apr 2016	27	19	15
May 2016	20	28	15
Jun 2016	20	37	19
Jul 2016	9	182	10
Aug 2016	9	28	7
Sep 2016	17	39	8
Oct 2016	16	34	12
Nov 2016	19	35	18
Dec 2016	9	123	8
Total 2016	275	617	177
Jan 2017	7	32	5
Feb 2017	6	271	12
Mar 2017	14	329	16
Apr 2017	8	35	4
May 2017	5	47	10
Jun 2017	9	26	7
Jul 2017	15	45	21
Aug 2017	3	28	9
Sep 2017	12	30	17
Oct 2017	7	29	13
Nov 2017	10	39	11
Dec 2017	7	30	6
Total 2017	103	941	131
Jan 2018	4	43	11
Feb 2018	14	48	6
Mar 2018	16	66	16
Apr 2018	7	51	8
May 2018	11	60	14
Jun 2018	7	47	9
Jul 2018	11	32	9
Aug 2018	2	24	15
Sep 2018	3	41	5
Oct 2018	6	36	4
Nov 2018	10	21	17
Dec 2018	5	24	6
Total 2018	96	493	120
Jan 2019	9	18	9
Feb 2019	9	41	14
Mar 2019	2	17	21
Apr 2019	9	27	22
May 2019	12	19	11
Jun 2019	6	22	14
Jul 2019	4	23	10
Aug 2019	7	101	17
Sep 2019	5	107	13
Oct 2019	9	125	10
Nov 2019	12	33	19
Dec 2019	2	43	5
Total 2019	86	576	165
Jan 2020	9	53	5
Feb 2020	6	46	9
Mar 2020	4	39	8
Apr 2020	7	62	8
May 2020	5	48	16
Jun 2020	5	31	8
Jul 2020	5	38	15
Aug 2020	6	14	16
Sep 2020	8	30	20
Oct 2020	6	15	13
Nov 2020	6	47	13
Dec 2020	10	47	23
Total 2020	77	470	154
Jan 2021	5	45	19
Total 2021	5	45	19
Total	5339	12205	6233