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ARTICLE, Behavioral/Systems

Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2B Adrenoceptors

Shigehito Sawamura, Wade S. Kingery, M. Frances Davies, Geeta S. Agashe, J. David Clark, Brian K. Kobilka, Toshizaku Hashimoto and Mervyn Maze
Journal of Neuroscience 15 December 2000, 20 (24) 9242-9251; DOI: https://doi.org/10.1523/JNEUROSCI.20-24-09242.2000
Shigehito Sawamura
1Departments of Anesthesia and
3Anesthesiology Service and
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Wade S. Kingery
2Functional Restoration, Stanford University School of Medicine, Stanford, California 94305,
4Physical Medicine and Rehabilitation Service, Veterans Affairs, Palo Alto Health Care System, Palo Alto, California 94304,
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M. Frances Davies
1Departments of Anesthesia and
3Anesthesiology Service and
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Geeta S. Agashe
1Departments of Anesthesia and
3Anesthesiology Service and
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J. David Clark
1Departments of Anesthesia and
3Anesthesiology Service and
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Brian K. Kobilka
5Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, and
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Toshizaku Hashimoto
6Magill Department of Anaesthetics, Imperial College School of Medicine, London SW10 9NH, United Kingdom
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Mervyn Maze
6Magill Department of Anaesthetics, Imperial College School of Medicine, London SW10 9NH, United Kingdom
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The Journal of Neuroscience: 20 (24)
Journal of Neuroscience
Vol. 20, Issue 24
15 Dec 2000
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Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2B Adrenoceptors
Shigehito Sawamura, Wade S. Kingery, M. Frances Davies, Geeta S. Agashe, J. David Clark, Brian K. Kobilka, Toshizaku Hashimoto, Mervyn Maze
Journal of Neuroscience 15 December 2000, 20 (24) 9242-9251; DOI: 10.1523/JNEUROSCI.20-24-09242.2000

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Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2B Adrenoceptors
Shigehito Sawamura, Wade S. Kingery, M. Frances Davies, Geeta S. Agashe, J. David Clark, Brian K. Kobilka, Toshizaku Hashimoto, Mervyn Maze
Journal of Neuroscience 15 December 2000, 20 (24) 9242-9251; DOI: 10.1523/JNEUROSCI.20-24-09242.2000
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Keywords

  • nitrous oxide
  • locus Coeruleus
  • noradrenergic
  • analgesia
  • anesthesia
  • Fos immunoreactivity

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