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ARTICLE, Cellular/Molecular

Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)

Frank N. Single, Andrei Rozov, Nail Burnashev, Frank Zimmermann, Daniel F. Hanley, Douglas Forrest, Tom Curran, Vidar Jensen, Øivind Hvalby, Rolf Sprengel and Peter H. Seeburg
Journal of Neuroscience 1 April 2000, 20 (7) 2558-2566; DOI: https://doi.org/10.1523/JNEUROSCI.20-07-02558.2000
Frank N. Single
1Max-Planck-Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstraβe 29, D-69120 Heidelberg, Germany,
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Andrei Rozov
1Max-Planck-Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstraβe 29, D-69120 Heidelberg, Germany,
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Nail Burnashev
1Max-Planck-Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstraβe 29, D-69120 Heidelberg, Germany,
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Frank Zimmermann
2Center for Molecular Biology, University of Heidelberg, D-69120 Heidelberg, Germany,
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Daniel F. Hanley
3Johns Hopkins School of Medicine, Department of Neurology, Baltimore, Maryland 21287-7840,
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Douglas Forrest
4Mount Sinai School of Medicine, Department of Human Genetics, New York, New York 10029,
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Tom Curran
5St. Jude Children's Research Hospital, Department of Developmental Neurobiology, Memphis, Tennessee 38105, and
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Vidar Jensen
6Institute of Basic Medical Sciences, Department of Neurophysiology, University of Oslo, Blindern, N-0317 Oslo, Norway
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Øivind Hvalby
6Institute of Basic Medical Sciences, Department of Neurophysiology, University of Oslo, Blindern, N-0317 Oslo, Norway
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Rolf Sprengel
1Max-Planck-Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstraβe 29, D-69120 Heidelberg, Germany,
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Peter H. Seeburg
1Max-Planck-Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstraβe 29, D-69120 Heidelberg, Germany,
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The Journal of Neuroscience: 20 (7)
Journal of Neuroscience
Vol. 20, Issue 7
1 Apr 2000
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Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)
Frank N. Single, Andrei Rozov, Nail Burnashev, Frank Zimmermann, Daniel F. Hanley, Douglas Forrest, Tom Curran, Vidar Jensen, Øivind Hvalby, Rolf Sprengel, Peter H. Seeburg
Journal of Neuroscience 1 April 2000, 20 (7) 2558-2566; DOI: 10.1523/JNEUROSCI.20-07-02558.2000

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Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)
Frank N. Single, Andrei Rozov, Nail Burnashev, Frank Zimmermann, Daniel F. Hanley, Douglas Forrest, Tom Curran, Vidar Jensen, Øivind Hvalby, Rolf Sprengel, Peter H. Seeburg
Journal of Neuroscience 1 April 2000, 20 (7) 2558-2566; DOI: 10.1523/JNEUROSCI.20-07-02558.2000
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Keywords

  • NMDA receptor
  • gene targeting
  • cre-loxP
  • Mg2+ block
  • Ca2+ influx
  • coincidence detection
  • respiration
  • nurturing
  • barrel cortex
  • LTP

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