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ARTICLE, Cellular/Molecular

The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice

Iris Augustin, Stefan Korte, Michael Rickmann, Hans A. Kretzschmar, Thomas C. Südhof, Jochen W. Herms and Nils Brose
Journal of Neuroscience 1 January 2001, 21 (1) 10-17; https://doi.org/10.1523/JNEUROSCI.21-01-00010.2001
Iris Augustin
1AG Molekulare Neurobiologie, Max-Planck-Institut für experimentelle Medizin, D-37075 Göttingen, Germany,
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Stefan Korte
2Institut für Neuropathologie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany,
3Institut für Neuropathologie, Ludwig-Maximilians-Universität München, D-81377 München, Germany,
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Michael Rickmann
4Zentrum Anatomie, Abteilung Neuroanatomie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany, and
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Hans A. Kretzschmar
2Institut für Neuropathologie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany,
3Institut für Neuropathologie, Ludwig-Maximilians-Universität München, D-81377 München, Germany,
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Thomas C. Südhof
5Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235
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Jochen W. Herms
2Institut für Neuropathologie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany,
3Institut für Neuropathologie, Ludwig-Maximilians-Universität München, D-81377 München, Germany,
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Nils Brose
1AG Molekulare Neurobiologie, Max-Planck-Institut für experimentelle Medizin, D-37075 Göttingen, Germany,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-01-00010.2001
PubMed 
11150314
Published By 
Society for Neuroscience
History 
  • Received August 28, 2000
  • Revision received October 6, 2000
  • Accepted October 11, 2000
  • First published January 1, 2001.
  • Version of record published January 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. Iris Augustin1,
  2. Stefan Korte2,3,
  3. Michael Rickmann4,
  4. Hans A. Kretzschmar2,3,
  5. Thomas C. Südhof5,
  6. Jochen W. Herms2,3, and
  7. Nils Brose1
  1. 1AG Molekulare Neurobiologie, Max-Planck-Institut für experimentelle Medizin, D-37075 Göttingen, Germany,
  2. 2Institut für Neuropathologie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany,
  3. 3Institut für Neuropathologie, Ludwig-Maximilians-Universität München, D-81377 München, Germany,
  4. 4Zentrum Anatomie, Abteilung Neuroanatomie, Georg-August-Universität Göttingen, D-37075 Göttingen, Germany, and
  5. 5Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235
View Full Text

Author contributions

Disclosures

    • Received August 28, 2000.
    • Revision received October 6, 2000.
    • Accepted October 11, 2000.
  • This work was supported by German Research Foundation Grants SFB406/A1 (to N.B.) and SFB406/A10 (to H.A.K. and J.W.H.) and by the Max-Planck-Society (N.B.). N.B. is a Heisenberg-Fellow of the German Research Foundation. We thank C. Rosenmund for helpful discussions and C. Pouzat for the program for analysis of spontaneous synaptic currents. We are particularly grateful to all members of the Max-Planck-Institut für experimentelle Medizin Animal Facility for help with mouse colonies, L. Kolb, J. Ficner, and R. Schubert for artwork, S. Wenger for excellent technical assistance, and F. Benseler and I. Thanhäuser for DNA synthesis and sequencing.

    Drs. Augustin and Korte contributed equally to this work

    Correspondence should be addressed to Nils Brose, Max-Planck-Institut für experimentelle Medizin, AG Molekulare Neurobiologie, Hermann-Rein-Straβe 3, D-37075 Göttingen, Germany. E-mail: brose{at}em.mpg.de.

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The Journal of Neuroscience: 21 (1)
Journal of Neuroscience
Vol. 21, Issue 1
1 Jan 2001
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The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice
Iris Augustin, Stefan Korte, Michael Rickmann, Hans A. Kretzschmar, Thomas C. Südhof, Jochen W. Herms, Nils Brose
Journal of Neuroscience 1 January 2001, 21 (1) 10-17; DOI: 10.1523/JNEUROSCI.21-01-00010.2001

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The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice
Iris Augustin, Stefan Korte, Michael Rickmann, Hans A. Kretzschmar, Thomas C. Südhof, Jochen W. Herms, Nils Brose
Journal of Neuroscience 1 January 2001, 21 (1) 10-17; DOI: 10.1523/JNEUROSCI.21-01-00010.2001
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Keywords

  • exocytosis
  • secretion
  • synaptic vesicle
  • priming
  • phorbol ester
  • unc-13

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