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ARTICLE, Cellular/Molecular

Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation

David A. Wagner and Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; DOI: https://doi.org/10.1523/JNEUROSCI.21-01-00067.2001
David A. Wagner
1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
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Cynthia Czajkowski
1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-01-00067.2001
PubMed 
11150321
Published By 
Society for Neuroscience
History 
  • Received August 25, 2000
  • Revision received October 10, 2000
  • Accepted October 23, 2000
  • First published January 1, 2001.
  • Version of record published January 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. David A. Wagner and
  2. Cynthia Czajkowski
  1. 1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
View Full Text

Author contributions

Disclosures

    • Received August 25, 2000.
    • Revision received October 10, 2000.
    • Accepted October 23, 2000.
  • This work was supported in part by National Institute of Neurological Disorders and Stroke Grants NS10579 (to D.W.) and NS34727 (to C.C.). C.C. is a recipient of the Burroughs Welcome Fund New Investigator Award in the Basic Pharmacological Sciences. We thank Amy Kucken, Jeremy Teissére, Dr. Andrew Boileau, Dr. Meyer Jackson, and Dr. Matt Jones for critical reading of this manuscript.

    Correspondence should be addressed to Dr. Cynthia Czajkowski, University of Wisconsin, Department of Physiology, Room 197 MSC, 1300 University Avenue, Madison, WI 53706. E-mail:czajkowski{at}physiology.wisc.edu.

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Article usage: January 2001 to February 2021

AbstractFullPdf
Jan 2001329246260
Feb 2001207748
Mar 2001157140
Apr 2001145128
May 2001106824
Jun 200162715
Jul 200172919
Aug 200153121
Sep 200132814
Oct 200122823
Nov 200173935
Dec 20012109
Total 2001420705536
Jan 200262218
Feb 200252417
Mar 200211213
Apr 200211623
May 20021913
Jun 20022915
Jul 2002377
Aug 2002258
Sep 20022813
Oct 20025912
Nov 200232013
Dec 20024209
Total 200235161161
Jan 200341815
Feb 200321611
Mar 200321412
Apr 200321010
May 200341714
Jun 200322113
Jul 200362417
Aug 2003112817
Sep 2003131516
Oct 2003242727
Nov 2003151778
Dec 2003162257
Total 2003101229287
Jan 2004162050
Feb 2004182624
Mar 2004233853
Apr 2004172835
May 2004202935
Jun 2004222516
Jul 2004192735
Aug 2004354647
Sep 2004315420
Oct 2004185815
Nov 2004176322
Dec 2004163017
Total 2004252444369
Jan 2005294057
Feb 2005314262
Mar 2005323444
Apr 2005232633
May 2005283025
Jun 2005232333
Jul 2005131912
Aug 200517399
Sep 200571424
Oct 200592822
Nov 2005133823
Dec 2005122626
Total 2005237359370
Jan 200651222
Feb 200661720
Mar 200682430
Apr 20067138
May 2006111520
Jun 200651614
Jul 200632010
Aug 20062624
Sep 2006131819
Oct 200692118
Nov 2006132233
Dec 200671316
Total 200689197234
Jan 200761918
Feb 200732023
Mar 200781713
Apr 2007152022
May 200792226
Jun 200781425
Jul 20073115
Aug 200741511
Sep 200761310
Oct 200741913
Nov 200761613
Dec 200751814
Total 200777204193
Jan 20084138
Feb 2008996
Mar 2008102021
Apr 200891213
May 2008231510
Jun 200819126
Jul 200891010
Aug 20089116
Sep 2008211713
Oct 200820166
Nov 2008181114
Dec 20085106
Total 2008156156119
Jan 20091268
Feb 20097166
Mar 200921119
Apr 2009291814
May 200992111
Jun 20097108
Jul 2009121610
Aug 2009585
Sep 20096129
Oct 20091058
Nov 2009101519
Dec 2009756
Total 2009135143113
Jan 20101146
Feb 201091010
Mar 2010141314
Apr 20104106
May 20103156
Jun 20102118
Jul 201021310
Aug 20107149
Sep 20105910
Oct 201010712
Nov 20108710
Dec 2010323
Total 201078115104
Jan 2011285
Feb 201191010
Mar 2011151516
Apr 2011357
May 2011101013
Jun 201141914
Jul 20117719
Aug 201181117
Sep 201114412
Oct 201130711
Nov 2011101012
Dec 20116817
Total 2011118114153
Jan 2012785
Feb 201241217
Mar 20126811
Apr 2012101214
May 201213412
Jun 201215614
Jul 2012579
Aug 2012448
Sep 20127810
Oct 20124416
Nov 20121958
Dec 20121945
Total 201211382129
Jan 2013181111
Feb 20131198
Mar 201315616
Apr 20133728
May 2013667
Jun 2013327
Jul 20137312
Aug 20136414
Sep 2013615
Oct 201310316
Nov 20135614
Dec 20136710
Total 20139665148
Jan 2014111010
Feb 20145710
Mar 2014412
Apr 201417818
May 20148812
Jun 2014444
Jul 2014161013
Aug 2014113
Sep 20141178
Oct 2014746
Nov 2014776
Dec 2014596
Total 2014967698
Jan 20152113
Feb 2015765
Mar 2015863
Apr 201541106
May 2015164
Jun 20155510
Jul 201561613
Aug 2015136
Sep 20151174
Oct 20151495
Nov 20151057
Dec 2015875
Total 20151149171
Jan 20168710
Feb 2016111114
Mar 2016976
Apr 2016646
May 2016101213
Jun 2016862
Jul 2016674
Aug 2016454
Sep 2016145
Oct 2016259
Nov 20168109
Dec 2016165
Total 2016748487
Jan 2017172
Feb 2017064
Mar 20170186
Apr 20170113
May 20177413
Jun 2017624
Jul 20176193
Aug 2017343
Sep 2017096
Oct 20170127
Nov 20173186
Dec 20170123
Total 20172615950
Jan 20185125
Feb 20182104
Mar 20186156
Apr 20183214
May 20185204
Jun 20180286
Jul 20180202
Aug 20180123
Sep 20180153
Oct 20181209
Nov 201832110
Dec 20180126
Total 20182520662
Jan 2019244
Feb 2019186
Mar 20191139
Apr 2019587
May 20192188
Jun 2019598
Jul 2019159
Aug 2019555
Sep 20190910
Oct 20193136
Nov 201921113
Dec 2019085
Total 20192711190
Jan 2020364
Feb 20203223
Mar 2020192
Apr 202051220
May 2020101210
Jun 20207311
Jul 2020256
Aug 2020031
Sep 20202174
Oct 20201305
Nov 20203107
Dec 20205125
Total 20204214178
Jan 20214225
Feb 202122613
Total 202164818
Total231738903470
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The Journal of Neuroscience: 21 (1)
Journal of Neuroscience
Vol. 21, Issue 1
1 Jan 2001
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Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
David A. Wagner, Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; DOI: 10.1523/JNEUROSCI.21-01-00067.2001

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Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
David A. Wagner, Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; DOI: 10.1523/JNEUROSCI.21-01-00067.2001
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Keywords

  • GABA
  • GABAA receptor
  • binding site
  • substituted cysteine accessibility method
  • cysteine mutagenesis
  • agonist efficacy
  • protein structure

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