Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
ARTICLE, Cellular/Molecular

Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation

David A. Wagner and Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; https://doi.org/10.1523/JNEUROSCI.21-01-00067.2001
David A. Wagner
1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cynthia Czajkowski
1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-01-00067.2001
PubMed 
11150321
Published By 
Society for Neuroscience
History 
  • Received August 25, 2000
  • Revision received October 10, 2000
  • Accepted October 23, 2000
  • First published January 1, 2001.
  • Version of record published January 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. David A. Wagner and
  2. Cynthia Czajkowski
  1. 1Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706
View Full Text

Author contributions

Disclosures

    • Received August 25, 2000.
    • Revision received October 10, 2000.
    • Accepted October 23, 2000.
  • This work was supported in part by National Institute of Neurological Disorders and Stroke Grants NS10579 (to D.W.) and NS34727 (to C.C.). C.C. is a recipient of the Burroughs Welcome Fund New Investigator Award in the Basic Pharmacological Sciences. We thank Amy Kucken, Jeremy Teissére, Dr. Andrew Boileau, Dr. Meyer Jackson, and Dr. Matt Jones for critical reading of this manuscript.

    Correspondence should be addressed to Dr. Cynthia Czajkowski, University of Wisconsin, Department of Physiology, Room 197 MSC, 1300 University Avenue, Madison, WI 53706. E-mail:czajkowski{at}physiology.wisc.edu.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-07-12
to
E.g., 2025-07-12

Article usage: January 2018 to July 2025

AbstractFullPdf
Jan 20185125
Feb 20182104
Mar 20186156
Apr 20183214
May 20185204
Jun 20180286
Jul 20180202
Aug 20180123
Sep 20180153
Oct 20181209
Nov 201832110
Dec 20180126
Total 20182520662
Jan 2019244
Feb 2019186
Mar 20191139
Apr 2019587
May 20192188
Jun 2019598
Jul 2019159
Aug 2019555
Oct 20193136
Nov 201921113
Dec 2019085
Total 20192710280
Jan 2020364
Feb 20203223
Mar 2020192
May 2020101210
Jun 20207311
Jul 2020256
Aug 2020031
Sep 20202174
Oct 20201305
Nov 20203107
Dec 20205125
Total 20203712958
Jan 20214225
Feb 202122713
Mar 202152015
Apr 20212146
May 202132612
Jun 20213239
Jul 2021367
Aug 20213184
Sep 20213204
Oct 202121217
Nov 202121522
Dec 20215164
Total 202137219118
Jan 20221169
Feb 20224125
Mar 20221164
Apr 20226193
May 20221139
Jun 202221510
Jul 20221110
Aug 20222167
Sep 20222107
Oct 20223127
Nov 2022061
Dec 2022182
Total 20222415464
Jan 20233226
Feb 20231144
Mar 20233339
Apr 20231157
May 20230105
Jun 20231114
Jul 2023387
Aug 20234108
Sep 20230132
Oct 20231185
Nov 202313175
Dec 20236318
Total 20233620270
Jan 20245306
Feb 20240153
Mar 20240253
Apr 20240237
May 202403212
Jun 20240174
Jul 20240305
Aug 202402412
Sep 20241229
Oct 20242246
Nov 20242178
Dec 20241246
Total 20241128381
Jan 202502515
Feb 20254478
Mar 202515811
Apr 202522720
May 20252265
Jun 20252195
Jul 2025033
Total 20251120567
Total2081500600
Back to top

In this issue

The Journal of Neuroscience: 21 (1)
Journal of Neuroscience
Vol. 21, Issue 1
1 Jan 2001
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
David A. Wagner, Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; DOI: 10.1523/JNEUROSCI.21-01-00067.2001

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
David A. Wagner, Cynthia Czajkowski
Journal of Neuroscience 1 January 2001, 21 (1) 67-74; DOI: 10.1523/JNEUROSCI.21-01-00067.2001
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • GABA
  • GABAA receptor
  • binding site
  • substituted cysteine accessibility method
  • cysteine mutagenesis
  • agonist efficacy
  • protein structure

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

ARTICLE

  • Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol
  • Cytoskeletal and Morphological Alterations Underlying Axonal Sprouting after Localized Transection of Cortical Neuron AxonsIn Vitro
  • Aberrant Chloride Transport Contributes to Anoxic/Ischemic White Matter Injury
Show more ARTICLE

Cellular/Molecular

  • Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol
  • Cytoskeletal and Morphological Alterations Underlying Axonal Sprouting after Localized Transection of Cortical Neuron AxonsIn Vitro
  • Aberrant Chloride Transport Contributes to Anoxic/Ischemic White Matter Injury
Show more Cellular/Molecular
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.