Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation

David A. Wagner; Cynthia Czajkowski

doi:10.1523/JNEUROSCI.21-01-00067.2001

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.21-01-00067.2001

PubMed

11150321

Published By

Society for Neuroscience

History

Received August 25, 2000
Revision received October 10, 2000
Accepted October 23, 2000
First published January 1, 2001.

Version of record published January 1, 2001.

Author Information

David A. Wagner and
Cynthia Czajkowski

¹Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706

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Author contributions

Disclosures

Received August 25, 2000.
Revision received October 10, 2000.
Accepted October 23, 2000.

This work was supported in part by National Institute of Neurological Disorders and Stroke Grants NS10579 (to D.W.) and NS34727 (to C.C.). C.C. is a recipient of the Burroughs Welcome Fund New Investigator Award in the Basic Pharmacological Sciences. We thank Amy Kucken, Jeremy Teissére, Dr. Andrew Boileau, Dr. Meyer Jackson, and Dr. Matt Jones for critical reading of this manuscript.
Correspondence should be addressed to Dr. Cynthia Czajkowski, University of Wisconsin, Department of Physiology, Room 197 MSC, 1300 University Avenue, Madison, WI 53706. E-mail:czajkowski{at}physiology.wisc.edu.

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	Abstract	Full	Pdf
Jan 2001	329	246	260
Feb 2001	20	77	48
Mar 2001	15	71	40
Apr 2001	14	51	28
May 2001	10	68	24
Jun 2001	6	27	15
Jul 2001	7	29	19
Aug 2001	5	31	21
Sep 2001	3	28	14
Oct 2001	2	28	23
Nov 2001	7	39	35
Dec 2001	2	10	9
Total 2001	420	705	536
Jan 2002	6	22	18
Feb 2002	5	24	17
Mar 2002	1	12	13
Apr 2002	1	16	23
May 2002	1	9	13
Jun 2002	2	9	15
Jul 2002	3	7	7
Aug 2002	2	5	8
Sep 2002	2	8	13
Oct 2002	5	9	12
Nov 2002	3	20	13
Dec 2002	4	20	9
Total 2002	35	161	161
Jan 2003	4	18	15
Feb 2003	2	16	11
Mar 2003	2	14	12
Apr 2003	2	10	10
May 2003	4	17	14
Jun 2003	2	21	13
Jul 2003	6	24	17
Aug 2003	11	28	17
Sep 2003	13	15	16
Oct 2003	24	27	27
Nov 2003	15	17	78
Dec 2003	16	22	57
Total 2003	101	229	287
Jan 2004	16	20	50
Feb 2004	18	26	24
Mar 2004	23	38	53
Apr 2004	17	28	35
May 2004	20	29	35
Jun 2004	22	25	16
Jul 2004	19	27	35
Aug 2004	35	46	47
Sep 2004	31	54	20
Oct 2004	18	58	15
Nov 2004	17	63	22
Dec 2004	16	30	17
Total 2004	252	444	369
Jan 2005	29	40	57
Feb 2005	31	42	62
Mar 2005	32	34	44
Apr 2005	23	26	33
May 2005	28	30	25
Jun 2005	23	23	33
Jul 2005	13	19	12
Aug 2005	17	39	9
Sep 2005	7	14	24
Oct 2005	9	28	22
Nov 2005	13	38	23
Dec 2005	12	26	26
Total 2005	237	359	370
Jan 2006	5	12	22
Feb 2006	6	17	20
Mar 2006	8	24	30
Apr 2006	7	13	8
May 2006	11	15	20
Jun 2006	5	16	14
Jul 2006	3	20	10
Aug 2006	2	6	24
Sep 2006	13	18	19
Oct 2006	9	21	18
Nov 2006	13	22	33
Dec 2006	7	13	16
Total 2006	89	197	234
Jan 2007	6	19	18
Feb 2007	3	20	23
Mar 2007	8	17	13
Apr 2007	15	20	22
May 2007	9	22	26
Jun 2007	8	14	25
Jul 2007	3	11	5
Aug 2007	4	15	11
Sep 2007	6	13	10
Oct 2007	4	19	13
Nov 2007	6	16	13
Dec 2007	5	18	14
Total 2007	77	204	193
Jan 2008	4	13	8
Feb 2008	9	9	6
Mar 2008	10	20	21
Apr 2008	9	12	13
May 2008	23	15	10
Jun 2008	19	12	6
Jul 2008	9	10	10
Aug 2008	9	11	6
Sep 2008	21	17	13
Oct 2008	20	16	6
Nov 2008	18	11	14
Dec 2008	5	10	6
Total 2008	156	156	119
Jan 2009	12	6	8
Feb 2009	7	16	6
Mar 2009	21	11	9
Apr 2009	29	18	14
May 2009	9	21	11
Jun 2009	7	10	8
Jul 2009	12	16	10
Aug 2009	5	8	5
Sep 2009	6	12	9
Oct 2009	10	5	8
Nov 2009	10	15	19
Dec 2009	7	5	6
Total 2009	135	143	113
Jan 2010	11	4	6
Feb 2010	9	10	10
Mar 2010	14	13	14
Apr 2010	4	10	6
May 2010	3	15	6
Jun 2010	2	11	8
Jul 2010	2	13	10
Aug 2010	7	14	9
Sep 2010	5	9	10
Oct 2010	10	7	12
Nov 2010	8	7	10
Dec 2010	3	2	3
Total 2010	78	115	104
Jan 2011	2	8	5
Feb 2011	9	10	10
Mar 2011	15	15	16
Apr 2011	3	5	7
May 2011	10	10	13
Jun 2011	4	19	14
Jul 2011	7	7	19
Aug 2011	8	11	17
Sep 2011	14	4	12
Oct 2011	30	7	11
Nov 2011	10	10	12
Dec 2011	6	8	17
Total 2011	118	114	153
Jan 2012	7	8	5
Feb 2012	4	12	17
Mar 2012	6	8	11
Apr 2012	10	12	14
May 2012	13	4	12
Jun 2012	15	6	14
Jul 2012	5	7	9
Aug 2012	4	4	8
Sep 2012	7	8	10
Oct 2012	4	4	16
Nov 2012	19	5	8
Dec 2012	19	4	5
Total 2012	113	82	129
Jan 2013	18	11	11
Feb 2013	11	9	8
Mar 2013	15	6	16
Apr 2013	3	7	28
May 2013	6	6	7
Jun 2013	3	2	7
Jul 2013	7	3	12
Aug 2013	6	4	14
Sep 2013	6	1	5
Oct 2013	10	3	16
Nov 2013	5	6	14
Dec 2013	6	7	10
Total 2013	96	65	148
Jan 2014	11	10	10
Feb 2014	5	7	10
Mar 2014	4	1	2
Apr 2014	17	8	18
May 2014	8	8	12
Jun 2014	4	4	4
Jul 2014	16	10	13
Aug 2014	1	1	3
Sep 2014	11	7	8
Oct 2014	7	4	6
Nov 2014	7	7	6
Dec 2014	5	9	6
Total 2014	96	76	98
Jan 2015	2	11	3
Feb 2015	7	6	5
Mar 2015	8	6	3
Apr 2015	41	10	6
May 2015	1	6	4
Jun 2015	5	5	10
Jul 2015	6	16	13
Aug 2015	1	3	6
Sep 2015	11	7	4
Oct 2015	14	9	5
Nov 2015	10	5	7
Dec 2015	8	7	5
Total 2015	114	91	71
Jan 2016	8	7	10
Feb 2016	11	11	14
Mar 2016	9	7	6
Apr 2016	6	4	6
May 2016	10	12	13
Jun 2016	8	6	2
Jul 2016	6	7	4
Aug 2016	4	5	4
Sep 2016	1	4	5
Oct 2016	2	5	9
Nov 2016	8	10	9
Dec 2016	1	6	5
Total 2016	74	84	87
Jan 2017	1	7	2
Feb 2017	0	6	4
Mar 2017	0	18	6
Apr 2017	0	11	3
May 2017	7	41	3
Jun 2017	6	2	4
Jul 2017	6	19	3
Aug 2017	3	4	3
Sep 2017	0	9	6
Oct 2017	0	12	7
Nov 2017	3	18	6
Dec 2017	0	12	3
Total 2017	26	159	50
Jan 2018	5	12	5
Feb 2018	2	10	4
Mar 2018	6	15	6
Apr 2018	3	21	4
May 2018	5	20	4
Jun 2018	0	28	6
Jul 2018	0	20	2
Aug 2018	0	12	3
Sep 2018	0	15	3
Oct 2018	1	20	9
Nov 2018	3	21	10
Dec 2018	0	12	6
Total 2018	25	206	62
Jan 2019	2	4	4
Feb 2019	1	8	6
Mar 2019	1	13	9
Apr 2019	5	8	7
May 2019	2	18	8
Jun 2019	5	9	8
Jul 2019	1	5	9
Aug 2019	5	5	5
Sep 2019	0	9	10
Oct 2019	3	13	6
Nov 2019	2	11	13
Dec 2019	0	8	5
Total 2019	27	111	90
Jan 2020	3	6	4
Feb 2020	3	22	3
Mar 2020	1	9	2
Apr 2020	5	12	20
May 2020	10	12	10
Jun 2020	7	3	11
Jul 2020	2	5	6
Aug 2020	0	3	1
Sep 2020	2	17	4
Oct 2020	1	30	5
Nov 2020	3	10	7
Dec 2020	5	12	5
Total 2020	42	141	78
Jan 2021	4	22	5
Feb 2021	2	26	13
Total 2021	6	48	18
Total	2317	3890	3470