Article Information
- Received February 15, 2001
- Revision received April 17, 2001
- Accepted April 19, 2001
- First published July 1, 2001.
- Version of record published July 1, 2001.
Author Information
- 1Department of Molecular Biology and Genetics,
- 2Division of Comparative Medicine,
- 3Department of Otolaryngology–Head and Neck Surgery,
- 4Department of Neuroscience, and
- 5Department of Ophthalmology,
- 6Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Author contributions
Disclosures
- Received February 15, 2001.
- Revision received April 17, 2001.
- Accepted April 19, 2001.
This work was supported by the Howard Hughes Medical Institute (Y.W., J.N.) and National Institutes of Health Grant DC00232 (H.C., D.R.). We thank Se-jin Lee for the 129/SVJ genomic library; Andras Nagy and Janet Rossant for ES cells; Richard Behringer for the knock-out vector; Jen-Chih Hsieh for assistance with mapping of genomic clones; Phil Smallwood for help with animal husbandry; Mitra Cowan, Diane Blesh, and Chip Hawkins for blastocyst injection; Anthony Wynshaw-Boris and Amy Chen for advice on ES cell methodology; David Linden, Mark Molliver, Elizabeth O'Hearn, Randy Reed, and Amir Rattner for helpful discussions; and Tudor Badea for helpful comments on this manuscript.
Correspondence should be addressed to Dr. Jeremy Nathans, 805 PCTB, 725 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205. E-mail: jnathans{at}jhmi.edu.
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