A β-Strand in the γ₂ Subunit Lines the Benzodiazepine Binding Site of the GABA_A Receptor: Structural Rearrangements Detected during Channel Gating

This work was supported in part by National Institute of Mental Health Grant MH12966 (J.A.T.) and by National Institute of Neurological Disorders and Stroke Grant NS34727 (C.C.). C.C. is a recipient of the Burroughs Wellcome Fund New Investigator Award in the Basic Pharmacological Sciences. We thank Drs. David Wagner, Andrew Boileau, and J. Glen Newell, as well as Amy Kucken, for a careful reading of this manuscript and invaluable discussion, and Erin McCarthy and Jeff Malik for oocyte preparation.

Correspondence should be addressed to Dr. Cynthia Czajkowski, Department of Physiology, University of Wisconsin, Room 197 MSC, 1300 University Avenue, Madison, WI 53706. E-mail:czajkowski{at}physiology.wisc.edu.