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ARTICLE, Development/Plasticity/Repair

Generation of a Novel Functional Neuronal Circuit inHoxa1 Mutant Mice

Eduardo Domı́nguez del Toro, Véronique Borday, Marc Davenne, Rüdiger Neun, Filippo M. Rijli and Jean Champagnat
Journal of Neuroscience 1 August 2001, 21 (15) 5637-5642; https://doi.org/10.1523/JNEUROSCI.21-15-05637.2001
Eduardo Domı́nguez del Toro
1Neurobiologie Génétique et Intégrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique (CNRS), 91198 Gif-sur-Yvette, France, and
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Véronique Borday
1Neurobiologie Génétique et Intégrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique (CNRS), 91198 Gif-sur-Yvette, France, and
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Marc Davenne
2Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Collège de France, BP 163-67404 Illkirch, Centre Universitaire de Strasbourg, France
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Rüdiger Neun
2Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Collège de France, BP 163-67404 Illkirch, Centre Universitaire de Strasbourg, France
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Filippo M. Rijli
2Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Collège de France, BP 163-67404 Illkirch, Centre Universitaire de Strasbourg, France
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Jean Champagnat
1Neurobiologie Génétique et Intégrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique (CNRS), 91198 Gif-sur-Yvette, France, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-15-05637.2001
PubMed 
11466434
Published By 
Society for Neuroscience
History 
  • Received September 28, 2000
  • Revision received April 11, 2001
  • Accepted May 1, 2001
  • First published August 1, 2001.
  • Version of record published August 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. Eduardo Domı́nguez del Toro1,
  2. Véronique Borday1,
  3. Marc Davenne2,
  4. Rüdiger Neun2,
  5. Filippo M. Rijli2, and
  6. Jean Champagnat1
  1. 1Neurobiologie Génétique et Intégrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique (CNRS), 91198 Gif-sur-Yvette, France, and
  2. 2Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Collège de France, BP 163-67404 Illkirch, Centre Universitaire de Strasbourg, France
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Author contributions

Disclosures

    • Received September 28, 2000.
    • Revision received April 11, 2001.
    • Accepted May 1, 2001.
  • Work in J.C.'s laboratory was supported by Human Frontier Science Program Research Grant 101/97, Action Concertée Incitative (Biologie du Développement et Physiologie Intégrative) #57 the Centre National de la Recherche Scientifique, and the Fondation pour la Recherche Médicale (FRM). E.D.T. was supported by The European Community (BIO4-CT975-096) and FRM (EP001227/1) training grants. Work in F.M.R.'s laboratory was supported by the CNRS, the Institut National de la Santé et de la Recherche Médicale, the Hôpital Universitaire de Strasbourg, the Ligue Nationale Contre le Cancer (LNCC), the Association pour la Recherche sur le Cancer, and the Programme Génome du CNRS. M.D. was supported by fellowships from the LNCC and FRM. R.N. was supported by Deutscher Akademischer Austauschdienst and FRM fellowships. We thank P. Chambon, G. Fortin, C. Goridis, R. Krumlauf, and A. Lumsden for valuable discussions and comments on this manuscript. We also thank T. Jacquin for his participation in some in vitro experiments and M. Poulet for excellent technical assistance. We acknowledge the following colleagues for kind gifts of reagents: P. Chambon (Hoxa1 mice), R. Krumlauf (BGZ40 plasmid and Hoxb1 probe), and J. F. Brunet (Phox2b probe). The 4D5 antibody was obtained from the Developmental Studies Hybridoma Bank under contract NO1-HD-7-3263.

    E.D.T., V.B., and M.D. contributed equally to this work

    Correspondence should be addressed to J. Champagnat, Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2216 (bât. 33), 91198 Gif-sur-Yvette, France. E-mail:Jean.Champagnat{at}iaf.cnrs-gif.fr.

    V. Borday's present address: Laboratoire de Biologie du Développement, Université Paris 7, case 7077, 2 place Jussieu, 75251 Paris, France.

    M. Davenne's present address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724.

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The Journal of Neuroscience: 21 (15)
Journal of Neuroscience
Vol. 21, Issue 15
1 Aug 2001
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Generation of a Novel Functional Neuronal Circuit inHoxa1 Mutant Mice
Eduardo Domı́nguez del Toro, Véronique Borday, Marc Davenne, Rüdiger Neun, Filippo M. Rijli, Jean Champagnat
Journal of Neuroscience 1 August 2001, 21 (15) 5637-5642; DOI: 10.1523/JNEUROSCI.21-15-05637.2001

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Generation of a Novel Functional Neuronal Circuit inHoxa1 Mutant Mice
Eduardo Domı́nguez del Toro, Véronique Borday, Marc Davenne, Rüdiger Neun, Filippo M. Rijli, Jean Champagnat
Journal of Neuroscience 1 August 2001, 21 (15) 5637-5642; DOI: 10.1523/JNEUROSCI.21-15-05637.2001
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Keywords

  • homeobox genes
  • Hoxa1 knock-out
  • respiration
  • suction
  • rhythm generation
  • rhombomeres
  • neural progenitors
  • migratory pathways
  • neuronal networks, reticular formation
  • pons
  • hindbrain
  • brainstem
  • newborn mice

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