Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor

This work was supported by National Institutes of Health Grant RO1NS36590 and NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (to G.C.B.) and National Science Foundation Grant IBN9809916 and Department of Defense Grant R070HY (to M.D.R.). Input from many individuals was invaluable to this project. We gratefully acknowledge the support and technical assistance of Christine Alocillo, Jon Cooke, William Coyle, James Gardner, Frank Giunpa, Rick Guyer, Robert Glasgow, John McDevitt, John Monnier, Charles Nelson, Jeff Santman, and Donna Wittkowski. We also deeply appreciate the assistance from Laine Brainard, Dr. Ignacio Provencio, Dr. Britt Sanford, and Dr. William Thornton in assessing the data, developing graphs, and reviewing this manuscript. The inspiration for this work came from the 281 series of the Edgar Cayce readings.

Correspondence should be addressed to Dr. George C. Brainard, Department of Neurology, Thomas Jefferson University, 1025 Walnut Street, Suite 310, Philadelphia, PA 19107. E-mail:george.brainard{at}mail.tju.edu.