Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
ARTICLE, Behavioral/Systems

Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor

George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner and Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: https://doi.org/10.1523/JNEUROSCI.21-16-06405.2001
George C. Brainard
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John P. Hanifin
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey M. Greeson
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brenda Byrne
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gena Glickman
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edward Gerner
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark D. Rollag
2Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-16-06405.2001
PubMed 
11487664
Published By 
Society for Neuroscience
History 
  • Received March 22, 2001
  • Revision received May 17, 2001
  • Accepted May 25, 2001
  • First published August 15, 2001.
  • Version of record published August 15, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. George C. Brainard1,
  2. John P. Hanifin1,
  3. Jeffrey M. Greeson1,
  4. Brenda Byrne1,
  5. Gena Glickman1,
  6. Edward Gerner1, and
  7. Mark D. Rollag2
  1. 1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  2. 2Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814
View Full Text

Author contributions

Disclosures

    • Received March 22, 2001.
    • Revision received May 17, 2001.
    • Accepted May 25, 2001.
  • This work was supported by National Institutes of Health Grant RO1NS36590 and NASA Cooperative Agreement NCC 9-58 with the National Space Biomedical Research Institute (to G.C.B.) and National Science Foundation Grant IBN9809916 and Department of Defense Grant R070HY (to M.D.R.). Input from many individuals was invaluable to this project. We gratefully acknowledge the support and technical assistance of Christine Alocillo, Jon Cooke, William Coyle, James Gardner, Frank Giunpa, Rick Guyer, Robert Glasgow, John McDevitt, John Monnier, Charles Nelson, Jeff Santman, and Donna Wittkowski. We also deeply appreciate the assistance from Laine Brainard, Dr. Ignacio Provencio, Dr. Britt Sanford, and Dr. William Thornton in assessing the data, developing graphs, and reviewing this manuscript. The inspiration for this work came from the 281 series of the Edgar Cayce readings.

    Correspondence should be addressed to Dr. George C. Brainard, Department of Neurology, Thomas Jefferson University, 1025 Walnut Street, Suite 310, Philadelphia, PA 19107. E-mail:george.brainard{at}mail.tju.edu.

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2023-02-01
to
E.g., 2023-02-01

Article usage: January 2018 to January 2023

AbstractFullPdf
Jan 20186125699
Feb 20186627498
Mar 201882387122
Apr 201867618149
May 201851971125
Jun 201871645114
Jul 201856417272
Aug 201844449274
Sep 201841526290
Oct 201876575306
Nov 201877484319
Dec 201861457286
Total 201875360592454
Jan 201995335226
Feb 201949273104
Mar 201989349118
Apr 201978334123
May 201954403125
Jun 20194524657
Jul 20193423596
Aug 201935227102
Oct 201976588142
Nov 201975461139
Dec 201958406164
Total 201968838571396
Jan 202051384141
Feb 202048441153
Mar 202051290190
May 202069324214
Jun 202026264164
Jul 202037626122
Aug 202045353249
Sep 202062369142
Oct 202047434277
Nov 202067383216
Dec 202050355203
Total 202055342232071
Jan 2021107486180
Feb 202171653276
Mar 202191495198
Apr 202177472226
May 202165320196
Jun 202148298136
Jul 202162320102
Aug 20213633590
Sep 202142312106
Oct 202154363207
Nov 202137331202
Dec 202161484172
Total 202175148692091
Jan 202261840218
Feb 202265385165
Mar 202262321146
Apr 202259665155
May 202265336106
Jun 20224930298
Jul 202257352108
Aug 20224831192
Sep 20224333987
Oct 202279361125
Nov 20221513229
Dec 20224219547
Total 202264545391376
Jan 202392517160
Total 202392517160
Total3482240649548
Back to top

In this issue

The Journal of Neuroscience: 21 (16)
Journal of Neuroscience
Vol. 21, Issue 16
15 Aug 2001
  • Table of Contents
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner, Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: 10.1523/JNEUROSCI.21-16-06405.2001

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner, Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: 10.1523/JNEUROSCI.21-16-06405.2001
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • melatonin
  • action spectrum
  • circadian
  • wavelength
  • light
  • pineal gland
  • neuroendocrine
  • photoreception
  • photopigment
  • human

Responses to this article

Respond to this article

Jump to comment:

  • Developing the family of curves for the Human Melatonin Action Spectrum
    Alan C. Haungs
    Published on: 10 December 2015
  • Published on: (10 December 2015)
    Page navigation anchor for Developing the family of curves for the Human Melatonin Action Spectrum
    Developing the family of curves for the Human Melatonin Action Spectrum
    • Alan C. Haungs, Inventor Owner

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak ac...

    Show More

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak action wavelength to the right, due to how the L and M cones constructively enhance the ipRGC signal during day- light adaptation.

    I would also hope to see such a family of curves for values of intensity that fit under the night-adaptation category.

    Such a family of curves would have utility from a circadian driver point of view when incorporating white light into the human living space, to defeat morning/mid-day SAD issues or evening circadian disruption issues.

    Conflict of Interest:

    I am an electrical engineer working on solutions to circadian disruption

    Show Less
    Competing Interests: None declared.

Related Articles

Cited By...

More in this TOC Section

ARTICLE

  • Distinct Developmental Modes and Lesion-Induced Reactions of Dendrites of Two Classes of Drosophila Sensory Neurons
  • Developmental Increase in Vesicular Glutamate Content Does Not Cause Saturation of AMPA Receptors at the Calyx of Held Synapse
  • Functional Dissociation among Components of Remembering: Control, Perceived Oldness, and Content
Show more ARTICLE

Behavioral/Systems

  • Enhancement of Signal-to-Noise Ratio and Phase Locking for Small Inputs by a Low-Threshold Outward Current in Auditory Neurons
  • Spinal Inhibitory Neurons that Modulate Cutaneous Sensory Pathways during Locomotion in a Simple Vertebrate
  • Efferent Protection from Acoustic Injury Is Mediated via α9 Nicotinic Acetylcholine Receptors on Outer Hair Cells
Show more Behavioral/Systems
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.