Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
ARTICLE, Behavioral/Systems

Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor

George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner and Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: https://doi.org/10.1523/JNEUROSCI.21-16-06405.2001
George C. Brainard
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John P. Hanifin
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey M. Greeson
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brenda Byrne
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gena Glickman
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edward Gerner
1Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark D. Rollag
2Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Published eLetters

Guidelines

As a forum for professional feedback, submissions of letters are open to all. You do not need to be a subscriber. To avoid redundancy, we urge you to read other people's letters before submitting your own. Name, current appointment, place of work, and email address are required to send a letter, and will be published with your review. We also require that you declare any competing financial interests. Unprofessional submissions will not be considered or responded to.

Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
8 + 7 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Vertical Tabs

Jump to comment:

  • Developing the family of curves for the Human Melatonin Action Spectrum
    Alan C. Haungs
    Submitted on: 10 December 2015
  • Submitted on: (10 December 2015)
    Page navigation anchor for Developing the family of curves for the Human Melatonin Action Spectrum
    Developing the family of curves for the Human Melatonin Action Spectrum
    • Alan C. Haungs, Inventor Owner

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak ac...

    Show More

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak action wavelength to the right, due to how the L and M cones constructively enhance the ipRGC signal during day- light adaptation.

    I would also hope to see such a family of curves for values of intensity that fit under the night-adaptation category.

    Such a family of curves would have utility from a circadian driver point of view when incorporating white light into the human living space, to defeat morning/mid-day SAD issues or evening circadian disruption issues.

    Conflict of Interest:

    I am an electrical engineer working on solutions to circadian disruption

    Show Less
    Competing Interests: None declared.
Back to top

In this issue

The Journal of Neuroscience: 21 (16)
Journal of Neuroscience
Vol. 21, Issue 16
15 Aug 2001
  • Table of Contents
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner, Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: 10.1523/JNEUROSCI.21-16-06405.2001

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
George C. Brainard, John P. Hanifin, Jeffrey M. Greeson, Brenda Byrne, Gena Glickman, Edward Gerner, Mark D. Rollag
Journal of Neuroscience 15 August 2001, 21 (16) 6405-6412; DOI: 10.1523/JNEUROSCI.21-16-06405.2001
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • melatonin
  • action spectrum
  • circadian
  • wavelength
  • light
  • pineal gland
  • neuroendocrine
  • photoreception
  • photopigment
  • human

Responses to this article

Respond to this article

Jump to comment:

  • Developing the family of curves for the Human Melatonin Action Spectrum
    Alan C. Haungs
    Published on: 10 December 2015
  • Published on: (10 December 2015)
    Page navigation anchor for Developing the family of curves for the Human Melatonin Action Spectrum
    Developing the family of curves for the Human Melatonin Action Spectrum
    • Alan C. Haungs, Inventor Owner

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak ac...

    Show More

    The original experiment for plotting the melatonin action spectrum involved instantaneous purified wavelengths.

    This is not typical light that enters the eye.

    I suggest superimposing white light on top of each purified wavelength and develop the family of curves as purified colors will likely have the left most peak action wavelength, but purified color + increasing amounts of white will move the peak action wavelength to the right, due to how the L and M cones constructively enhance the ipRGC signal during day- light adaptation.

    I would also hope to see such a family of curves for values of intensity that fit under the night-adaptation category.

    Such a family of curves would have utility from a circadian driver point of view when incorporating white light into the human living space, to defeat morning/mid-day SAD issues or evening circadian disruption issues.

    Conflict of Interest:

    I am an electrical engineer working on solutions to circadian disruption

    Show Less
    Competing Interests: None declared.

Related Articles

Cited By...

More in this TOC Section

ARTICLE

  • A Precise Retinotopic Map of Primate Striate Cortex Generated from the Representation of Angioscotomas
  • Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in Aplysia
  • Evidence for Long-Lasting Cholinergic Control of Gap Junctional Communication between Adrenal Chromaffin Cells
Show more ARTICLE

Behavioral/Systems

  • Sensitivity to Instrumental Contingency Degradation Is Mediated by the Entorhinal Cortex and Its Efferents via the Dorsal Hippocampus
  • Evidence for Sequential Decision Making in the Medicinal Leech
  • Highly Variable Spike Trains Underlie Reproducible Sensorimotor Responses in the Medicinal Leech
Show more Behavioral/Systems
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.