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ARTICLE, Cellular/Molecular

Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity

M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart and K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; https://doi.org/10.1523/JNEUROSCI.21-17-06475.2001
M. van der Stelt
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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W. B. Veldhuis
2Department of Experimental In Vivo NMR, Image Sciences Institute, 3584 CJ, Utrecht, University Medical Center Utrecht, The Netherlands, and
3Department of Experimental Neurology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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P. R. Bär
3Department of Experimental Neurology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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G. A. Veldink
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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J. F. G. Vliegenthart
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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K. Nicolay
2Department of Experimental In Vivo NMR, Image Sciences Institute, 3584 CJ, Utrecht, University Medical Center Utrecht, The Netherlands, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-17-06475.2001
PubMed 
11517236
Published By 
Society for Neuroscience
History 
  • Received March 22, 2001
  • Revision received May 31, 2001
  • Accepted June 14, 2001
  • First published September 1, 2001.
  • Version of record published September 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. M. van der Stelt1,
  2. W. B. Veldhuis2,3,
  3. P. R. Bär3,
  4. G. A. Veldink1,
  5. J. F. G. Vliegenthart1, and
  6. K. Nicolay2
  1. 1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
  2. 2Department of Experimental In Vivo NMR, Image Sciences Institute, 3584 CJ, Utrecht, University Medical Center Utrecht, The Netherlands, and
  3. 3Department of Experimental Neurology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
View Full Text

Author contributions

Disclosures

    • Received March 22, 2001.
    • Revision received May 31, 2001.
    • Accepted June 14, 2001.
  • W.B.V. is financially supported by the Netherlands Organization for Scientific Research, Medical Sciences Council. We are indebted to H. Veldman and G. van Haaften for expert technical assistance. Sanofi Recherche is gratefully acknowledged for the gift of SR141716. We thank Dr. R. Dijkhuizen for fruitful discussions and Dr. R. van Sluis for the development of the data analysis program.

    M.vdS. and W.B.V. contributed equally to the work.

    Correspondence should be addressed to G. A. Veldink, Department of Bio-organic Chemistry, Bijvoet Center for Biomolecular Research, Padualaan 8, 3584 CH, Utrecht University, Utrecht, The Netherlands. E-mail: veldink{at}accu.uu.nl.

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May 202517710816
Jun 20251569021
Jul 20251199819
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Total 202516061159236
Total23589184202208
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The Journal of Neuroscience: 21 (17)
Journal of Neuroscience
Vol. 21, Issue 17
1 Sep 2001
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Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart, K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; DOI: 10.1523/JNEUROSCI.21-17-06475.2001

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Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart, K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; DOI: 10.1523/JNEUROSCI.21-17-06475.2001
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Keywords

  • anandamide
  • astrogliosis
  • cannabinoid
  • excitotoxicity
  • magnetic resonance imaging
  • neonatal rat
  • neuroprotection
  • ouabain
  • THC

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