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ARTICLE, Cellular/Molecular

Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity

M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart and K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; DOI: https://doi.org/10.1523/JNEUROSCI.21-17-06475.2001
M. van der Stelt
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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W. B. Veldhuis
2Department of Experimental In Vivo NMR, Image Sciences Institute, 3584 CJ, Utrecht, University Medical Center Utrecht, The Netherlands, and
3Department of Experimental Neurology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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P. R. Bär
3Department of Experimental Neurology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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G. A. Veldink
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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J. F. G. Vliegenthart
1Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, 3584 CH, Utrecht University, Utrecht, The Netherlands,
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K. Nicolay
2Department of Experimental In Vivo NMR, Image Sciences Institute, 3584 CJ, Utrecht, University Medical Center Utrecht, The Netherlands, and
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    Fig. 1.

    Three adjacent coronal ADC maps of neonatal rat brain 15 min after ouabain injection. a, No treatment;b, THC treatment; c, THC + SR141716 treatment. Hypointensities correlate to cytotoxic edema.

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    Fig. 2.

    Mean lesion volumes (±SE) of ouabain-injected rats on days 0 and 7, based on ADC and T2 map analysis.

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    Fig. 3.

    Three adjacent coronal T2 maps of neonatal rat brain 7 d after ouabain injection. a,No treatment; b, THC treatment; c, THC + SR141716 treatment. Hyperintensities correlate to ventricle dilatation, vasogenic edema, and tissue loss, whereas hypointensities correlate to astrogliosis.

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    Fig. 4.

    GFAP staining of a brain section of a ouabain-injected rat. Markedly increased staining was observed in the thalamus, external capsule, and cortex of the injected hemisphere, whereas normal staining was seen in the contralateral hemisphere.

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The Journal of Neuroscience: 21 (17)
Journal of Neuroscience
Vol. 21, Issue 17
1 Sep 2001
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Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart, K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; DOI: 10.1523/JNEUROSCI.21-17-06475.2001

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Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
M. van der Stelt, W. B. Veldhuis, P. R. Bär, G. A. Veldink, J. F. G. Vliegenthart, K. Nicolay
Journal of Neuroscience 1 September 2001, 21 (17) 6475-6479; DOI: 10.1523/JNEUROSCI.21-17-06475.2001
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Keywords

  • anandamide
  • astrogliosis
  • cannabinoid
  • excitotoxicity
  • magnetic resonance imaging
  • neonatal rat
  • neuroprotection
  • ouabain
  • THC

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