The C Terminus of the Human Nicotinic α4β2 Receptor Forms a Binding Site Required for Potentiation by an Estrogenic Steroid

This work was supported by National Institutes of Health Grants P01 GM47969 and R01 NS22356 (J.H.S.). J.H.S. is the Russell and Mary Shelden Professor of Anesthesiology. We thank Dr. Douglas F. Covey for providing steroids and for advice on their use and effects, G. Akk for comments during the studies, and J. Bracamontes for advice on molecular biology.

Correspondence should be addressed to Dr. Kenneth Paradiso, Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail:paradiso{at}morpheus.wustl.edu.