The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Giselle P. Lim; Teresa Chu; Fusheng Yang; Walter Beech; Sally A. Frautschy; Greg M. Cole

doi:10.1523/JNEUROSCI.21-21-08370.2001

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.21-21-08370.2001

PubMed

11606625

Published By

Society for Neuroscience

History

Received July 12, 2001
Revision received August 6, 2001
Accepted August 22, 2001
First published November 1, 2001.

Version of record published November 1, 2001.

Author Information

Giselle P. Lim1,3,
Teresa Chu1,3,
Fusheng Yang1,3,
Walter Beech1,3,
Sally A. Frautschy1,2,3, and
Greg M. Cole1,2,3

¹Departments of Medicine and
²Neurology, University of California, Los Angeles, Los Angeles, California 90095, and
³Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Sepulveda, California 91343

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Author contributions

Disclosures

Received July 12, 2001.
Revision received August 6, 2001.
Accepted August 22, 2001.

This work was supported by National Institute on Aging Grant AG13471 (G.M.C.), Veterans Affairs Merit, the Alzheimer Association, and The Elizabeth and Thomas Plott Family Foundation. We thank Dr. Karen Hsiao Ashe for her continued support and collaboration in studies pertaining to the Tg2576 mouse. We acknowledge Boris Oks, John Alcantara, Veronica Talamantes, and Ulises Garcia for their excellent work genotyping the transgenic mice. We are also grateful to Dr. Judith Harker for her help with the statistical analyses.
Correspondence should be addressed to Dr. Gregory M. Cole, Greater Los Angeles Veterans Affairs Healthcare System, GRECC11E, University of Los Angeles, Departments of Medicine and Neurology (San Fernando Valley Program), 16111 Plummer Street, Sepulveda, CA 91343. E-mail: gmcole{at}ucla.edu.

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	Abstract	Full	Pdf
Oct 2001	793	560	563
Nov 2001	395	595	396
Dec 2001	47	362	170
Total 2001	1235	1517	1129
Jan 2002	52	270	122
Feb 2002	59	255	108
Mar 2002	51	192	112
Apr 2002	25	157	88
May 2002	9	105	66
Jun 2002	12	82	54
Jul 2002	13	85	58
Aug 2002	37	94	75
Sep 2002	19	77	73
Oct 2002	19	99	85
Nov 2002	15	102	117
Dec 2002	12	66	72
Total 2002	323	1584	1030
Jan 2003	35	81	65
Feb 2003	12	91	76
Mar 2003	20	84	81
Apr 2003	33	79	75
May 2003	22	117	95
Jun 2003	12	113	92
Jul 2003	33	107	80
Aug 2003	40	119	74
Sep 2003	30	119	73
Oct 2003	26	114	83
Nov 2003	37	135	81
Dec 2003	29	138	37
Total 2003	329	1297	912
Jan 2004	40	137	61
Feb 2004	13	104	67
Mar 2004	32	123	71
Apr 2004	29	136	92
May 2004	46	178	89
Jun 2004	44	206	92
Jul 2004	45	93	55
Aug 2004	56	181	68
Sep 2004	31	180	101
Oct 2004	33	214	110
Nov 2004	39	154	102
Dec 2004	54	200	101
Total 2004	462	1906	1009
Jan 2005	75	358	212
Feb 2005	69	278	149
Mar 2005	56	268	162
Apr 2005	27	229	162
May 2005	45	230	139
Jun 2005	45	204	112
Jul 2005	40	240	153
Aug 2005	38	224	121
Sep 2005	35	192	103
Oct 2005	34	327	183
Nov 2005	47	302	143
Dec 2005	35	208	106
Total 2005	546	3060	1745
Jan 2006	17	235	106
Feb 2006	36	179	104
Mar 2006	40	215	94
Apr 2006	40	217	109
May 2006	55	200	102
Jun 2006	76	165	93
Jul 2006	63	129	100
Aug 2006	66	150	99
Sep 2006	61	179	110
Oct 2006	97	291	204
Nov 2006	86	194	137
Dec 2006	81	150	97
Total 2006	718	2304	1355
Jan 2007	119	218	148
Feb 2007	98	181	118
Mar 2007	128	221	118
Apr 2007	87	223	117
May 2007	65	161	106
Jun 2007	42	165	88
Jul 2007	77	170	104
Aug 2007	79	165	99
Sep 2007	69	136	92
Oct 2007	88	172	114
Nov 2007	81	138	122
Dec 2007	73	138	76
Total 2007	1006	2088	1302
Jan 2008	90	130	91
Feb 2008	85	120	79
Mar 2008	106	177	106
Apr 2008	81	122	97
May 2008	95	127	94
Jun 2008	92	146	93
Jul 2008	93	136	81
Aug 2008	94	132	69
Sep 2008	118	108	86
Oct 2008	95	120	90
Nov 2008	119	107	95
Dec 2008	98	91	88
Total 2008	1166	1516	1069
Jan 2009	66	97	87
Feb 2009	106	137	112
Mar 2009	135	143	125
Apr 2009	108	101	122
May 2009	92	84	72
Jun 2009	151	105	122
Jul 2009	44	159	87
Aug 2009	32	127	59
Sep 2009	28	149	97
Oct 2009	54	180	117
Nov 2009	52	195	112
Dec 2009	21	152	101
Total 2009	889	1629	1213
Jan 2010	25	169	86
Feb 2010	36	159	80
Mar 2010	32	198	224
Apr 2010	36	276	101
May 2010	25	224	84
Jun 2010	32	186	65
Jul 2010	29	378	94
Aug 2010	47	241	107
Sep 2010	24	205	94
Oct 2010	36	246	143
Nov 2010	56	262	120
Dec 2010	26	178	83
Total 2010	404	2722	1281
Jan 2011	23	168	91
Feb 2011	21	212	101
Mar 2011	91	238	89
Apr 2011	101	196	81
May 2011	94	112	116
Jun 2011	69	88	76
Jul 2011	90	89	108
Aug 2011	71	99	119
Sep 2011	98	170	81
Oct 2011	81	145	82
Nov 2011	109	189	137
Dec 2011	131	143	121
Total 2011	979	1849	1202
Jan 2012	93	125	128
Feb 2012	92	145	126
Mar 2012	129	151	141
Apr 2012	129	172	197
May 2012	124	155	156
Jun 2012	102	140	121
Jul 2012	110	155	154
Aug 2012	76	93	132
Sep 2012	96	88	123
Oct 2012	130	125	156
Nov 2012	122	141	134
Dec 2012	116	98	134
Total 2012	1319	1588	1702
Jan 2013	116	130	106
Feb 2013	127	114	105
Mar 2013	137	110	112
Apr 2013	145	133	109
May 2013	109	111	126
Jun 2013	79	88	89
Jul 2013	99	96	100
Aug 2013	111	80	84
Sep 2013	118	93	132
Oct 2013	171	183	139
Nov 2013	127	136	95
Dec 2013	118	88	120
Total 2013	1457	1362	1317
Jan 2014	109	170	59
Feb 2014	103	123	71
Mar 2014	148	151	117
Apr 2014	120	104	139
May 2014	180	119	162
Jun 2014	161	120	55
Jul 2014	110	165	120
Aug 2014	122	167	353
Sep 2014	195	188	113
Oct 2014	183	123	85
Nov 2014	148	166	67
Dec 2014	144	115	44
Total 2014	1723	1711	1385
Jan 2015	187	131	104
Feb 2015	126	100	64
Mar 2015	173	137	118
Apr 2015	151	97	79
May 2015	136	126	87
Jun 2015	172	94	73
Jul 2015	108	126	77
Aug 2015	131	104	40
Sep 2015	216	96	55
Oct 2015	325	188	102
Nov 2015	388	137	106
Dec 2015	170	96	58
Total 2015	2283	1432	963
Jan 2016	354	90	67
Feb 2016	181	90	73
Mar 2016	172	142	92
Apr 2016	162	130	82
May 2016	202	130	114
Jun 2016	131	113	88
Jul 2016	116	123	61
Aug 2016	161	108	150
Sep 2016	106	119	95
Oct 2016	157	103	129
Nov 2016	137	122	123
Dec 2016	84	107	111
Total 2016	1963	1377	1185
Jan 2017	126	177	90
Feb 2017	123	148	140
Mar 2017	108	164	108
Apr 2017	190	127	84
May 2017	139	170	116
Jun 2017	98	111	61
Jul 2017	111	117	65
Aug 2017	85	137	86
Sep 2017	93	138	62
Oct 2017	104	249	138
Nov 2017	128	208	93
Dec 2017	99	149	74
Total 2017	1404	1895	1117
Jan 2018	175	282	86
Feb 2018	109	162	86
Mar 2018	168	198	81
Apr 2018	182	173	93
May 2018	148	192	87
Jun 2018	113	201	72
Jul 2018	130	145	89
Aug 2018	99	116	74
Sep 2018	116	139	85
Oct 2018	183	164	75
Nov 2018	137	150	67
Dec 2018	127	382	107
Total 2018	1687	2304	1002
Jan 2019	111	497	83
Feb 2019	130	175	40
Mar 2019	125	155	81
Apr 2019	125	115	65
May 2019	78	132	36
Jun 2019	53	111	44
Jul 2019	60	106	46
Aug 2019	45	173	55
Sep 2019	48	181	70
Oct 2019	55	214	46
Nov 2019	56	75	47
Dec 2019	47	131	69
Total 2019	933	2065	682
Jan 2020	37	120	38
Feb 2020	40	102	39
Mar 2020	36	89	36
Apr 2020	37	87	46
May 2020	33	81	37
Jun 2020	21	73	30
Jul 2020	33	93	55
Aug 2020	28	77	55
Sep 2020	43	115	53
Oct 2020	33	148	77
Nov 2020	35	125	48
Dec 2020	30	121	44
Total 2020	406	1231	558
Jan 2021	35	143	58
Feb 2021	27	158	62
Mar 2021	44	183	42
Apr 2021	128	163	45
May 2021	38	197	37
Jun 2021	52	181	41
Jul 2021	36	181	52
Aug 2021	56	164	34
Sep 2021	32	175	23
Oct 2021	43	191	83
Nov 2021	32	175	45
Dec 2021	59	267	47
Total 2021	582	2178	569
Jan 2022	42	162	63
Total 2022	42	162	63
Total	21856	38777	23790