Plasma Membrane Ganglioside Sialidase Regulates Axonal Growth and Regeneration in Hippocampal Neurons in Culture

Jose Abad Rodriguez; Eugenia Piddini; Takafumi Hasegawa; Taeko Miyagi; Carlos G. Dotti

doi:10.1523/JNEUROSCI.21-21-08387.2001

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.21-21-08387.2001

PubMed

11606627

Published By

Society for Neuroscience

History

Received June 11, 2001
Revision received August 6, 2001
Accepted August 24, 2001
First published November 1, 2001.

Version of record published November 1, 2001.

Author Information

Jose Abad Rodriguez2,3,
Eugenia Piddini3,
Takafumi Hasegawa1,
Taeko Miyagi1, and
Carlos G. Dotti2,3

¹Miyagi Prefectural Cancer Center, Division of Biochemistry, Medeshima-Shiode, Natori, Miyagi, 981-1293 Japan,
²Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, A. O. San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (TO), Italy, and
³Cell Biology and Biophysics Program, European Molecular Biology Laboratory, 69012 Heidelberg, Germany

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Author contributions

Disclosures

Received June 11, 2001.
Revision received August 6, 2001.
Accepted August 24, 2001.

We thank Drs. Frank Bradke, Lola Ledesma, Jorge Santos Da Silva, and Beatriz Gil for scientific advice and discussions, and Bianca Hellias and Etienne Cassin for the preparation and maintenance of the hippocampal neurons.
Correspondence should be addressed to Cavalieri Ottolenghi, Scientific Institute, Universita degli Studi di Torino, A. O. San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano (TO), Italy. E-mail:carlos.dotti{at}unito.it

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	Abstract	Full	Pdf
Oct 2001	194	209	209
Nov 2001	60	133	106
Dec 2001	12	51	37
Total 2001	266	393	352
Jan 2002	9	81	48
Feb 2002	6	79	35
Mar 2002	4	37	16
Apr 2002	1	39	28
May 2002	3	53	36
Jun 2002	2	31	14
Jul 2002	8	41	37
Aug 2002	7	28	16
Sep 2002	5	25	13
Oct 2002	8	38	22
Nov 2002	6	47	44
Dec 2002	3	15	6
Total 2002	62	514	315
Jan 2003	3	17	15
Feb 2003	1	17	30
Mar 2003	1	26	24
Apr 2003	0	12	9
May 2003	3	29	21
Jun 2003	3	26	11
Jul 2003	8	32	7
Aug 2003	9	25	13
Sep 2003	9	25	8
Oct 2003	15	24	8
Nov 2003	15	26	10
Dec 2003	17	41	8
Total 2003	84	300	164
Jan 2004	18	31	18
Feb 2004	12	38	16
Mar 2004	18	32	9
Apr 2004	26	28	19
May 2004	15	36	14
Jun 2004	23	31	12
Jul 2004	10	34	10
Aug 2004	27	37	13
Sep 2004	29	53	22
Oct 2004	24	42	15
Nov 2004	14	28	15
Dec 2004	13	23	2
Total 2004	229	413	165
Jan 2005	17	30	10
Feb 2005	18	42	7
Mar 2005	14	25	17
Apr 2005	12	31	14
May 2005	5	46	35
Jun 2005	15	24	15
Jul 2005	3	28	15
Aug 2005	7	24	14
Sep 2005	4	26	14
Oct 2005	9	32	12
Nov 2005	14	40	13
Dec 2005	8	23	19
Total 2005	126	371	185
Jan 2006	6	27	14
Feb 2006	3	20	12
Mar 2006	6	37	12
Apr 2006	5	7	5
May 2006	0	17	8
Jun 2006	3	11	12
Jul 2006	7	24	15
Aug 2006	7	14	11
Sep 2006	11	24	11
Oct 2006	5	22	24
Nov 2006	10	29	14
Dec 2006	3	13	13
Total 2006	66	245	151
Jan 2007	4	16	16
Feb 2007	8	18	14
Mar 2007	5	13	21
Apr 2007	7	13	9
May 2007	6	18	16
Jun 2007	7	14	2
Jul 2007	2	10	8
Aug 2007	5	15	15
Sep 2007	3	17	12
Oct 2007	7	24	18
Nov 2007	10	18	13
Dec 2007	4	16	8
Total 2007	68	192	152
Jan 2008	3	6	9
Feb 2008	8	15	9
Mar 2008	14	20	19
Apr 2008	12	18	3
May 2008	15	18	6
Jun 2008	21	25	19
Jul 2008	7	24	15
Aug 2008	10	21	10
Sep 2008	31	14	8
Oct 2008	17	16	8
Nov 2008	19	14	7
Dec 2008	10	8	8
Total 2008	167	199	121
Jan 2009	9	17	8
Feb 2009	8	14	9
Mar 2009	9	17	3
Apr 2009	7	20	12
May 2009	7	13	14
Jun 2009	12	16	8
Jul 2009	9	10	3
Aug 2009	8	14	13
Sep 2009	13	18	11
Oct 2009	9	12	12
Nov 2009	14	25	17
Dec 2009	8	9	7
Total 2009	113	185	117
Jan 2010	15	18	11
Feb 2010	15	10	16
Mar 2010	9	22	8
Apr 2010	9	25	11
May 2010	14	12	6
Jun 2010	4	22	11
Jul 2010	9	10	10
Aug 2010	6	6	8
Sep 2010	10	14	11
Oct 2010	16	17	9
Nov 2010	11	18	15
Dec 2010	4	3	5
Total 2010	122	177	121
Jan 2011	8	11	9
Feb 2011	10	8	14
Mar 2011	13	11	12
Apr 2011	9	7	7
May 2011	16	16	17
Jun 2011	8	7	21
Jul 2011	5	10	16
Aug 2011	7	10	12
Sep 2011	19	5	9
Oct 2011	23	14	18
Nov 2011	18	11	21
Dec 2011	12	7	14
Total 2011	148	117	170
Jan 2012	8	9	8
Feb 2012	17	13	20
Mar 2012	18	25	12
Apr 2012	18	6	9
May 2012	19	5	8
Jun 2012	9	13	17
Jul 2012	10	14	14
Aug 2012	18	8	17
Sep 2012	16	11	15
Oct 2012	28	10	15
Nov 2012	33	7	17
Dec 2012	27	13	12
Total 2012	221	134	164
Jan 2013	27	9	13
Feb 2013	22	6	11
Mar 2013	20	8	15
Apr 2013	19	9	10
May 2013	17	10	14
Jun 2013	11	10	5
Jul 2013	15	2	5
Aug 2013	22	9	10
Sep 2013	15	2	4
Oct 2013	10	2	8
Nov 2013	19	3	4
Dec 2013	10	6	11
Total 2013	207	76	110
Jan 2014	11	5	10
Feb 2014	11	8	9
Mar 2014	6	11	20
Apr 2014	29	6	8
May 2014	14	10	12
Jun 2014	14	3	5
Jul 2014	32	7	6
Aug 2014	12	3	10
Sep 2014	56	6	12
Oct 2014	18	7	9
Nov 2014	10	8	8
Dec 2014	13	7	10
Total 2014	226	81	119
Jan 2015	8	5	3
Feb 2015	15	12	6
Mar 2015	8	9	9
Apr 2015	11	2	2
May 2015	14	11	4
Jun 2015	9	5	11
Jul 2015	19	4	5
Aug 2015	7	5	2
Sep 2015	7	3	5
Oct 2015	7	8	5
Nov 2015	3	3	9
Dec 2015	6	2	14
Total 2015	114	69	75
Jan 2016	5	6	11
Feb 2016	6	11	7
Mar 2016	7	6	8
Apr 2016	11	8	5
May 2016	2	8	6
Jun 2016	3	8	6
Jul 2016	5	18	18
Aug 2016	9	2	6
Sep 2016	4	4	2
Oct 2016	0	4	5
Nov 2016	6	239	17
Dec 2016	0	6	3
Total 2016	58	320	94
Jan 2017	3	5	4
Feb 2017	2	7	4
Mar 2017	5	12	10
Apr 2017	0	14	14
May 2017	0	24	8
Jun 2017	3	10	7
Jul 2017	1	8	2
Aug 2017	1	5	1
Sep 2017	2	9	2
Oct 2017	1	9	5
Nov 2017	4	11	7
Dec 2017	3	7	5
Total 2017	25	121	69
Jan 2018	0	13	4
Feb 2018	3	3	6
Mar 2018	4	3	2
Apr 2018	5	17	8
May 2018	2	16	3
Jun 2018	1	13	1
Jul 2018	0	7	3
Aug 2018	0	9	2
Sep 2018	4	24	3
Oct 2018	1	16	7
Nov 2018	1	13	5
Dec 2018	4	6	3
Total 2018	25	140	47
Jan 2019	1	21	7
Feb 2019	2	16	11
Mar 2019	5	10	2
Apr 2019	2	19	11
May 2019	4	6	2
Jun 2019	0	9	5
Jul 2019	1	4	7
Aug 2019	1	15	10
Sep 2019	5	9	7
Oct 2019	2	13	29
Nov 2019	3	9	11
Dec 2019	2	12	3
Total 2019	28	143	105
Jan 2020	4	11	2
Feb 2020	4	17	6
Mar 2020	1	7	4
Apr 2020	5	4	10
May 2020	1	12	6
Jun 2020	1	5	2
Jul 2020	1	13	12
Aug 2020	4	5	5
Sep 2020	1	11	1
Oct 2020	3	11	6
Nov 2020	7	11	5
Dec 2020	2	12	7
Total 2020	34	119	66
Jan 2021	4	11	9
Feb 2021	2	46	17
Mar 2021	11	17	12
Apr 2021	4	18	4
May 2021	4	12	5
Jun 2021	1	15	3
Jul 2021	1	7	14
Aug 2021	2	12	11
Sep 2021	5	14	4
Oct 2021	3	15	18
Nov 2021	0	10	13
Dec 2021	1	14	11
Total 2021	38	191	121
Jan 2022	1	12	8
Feb 2022	2	8	5
Mar 2022	0	10	6
Apr 2022	0	8	1
May 2022	0	3	6
Total 2022	3	41	26
Total	2430	4541	3009