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ARTICLE, Behavioral/Systems

Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats

Pam Blundell, Geoffrey Hall and Simon Killcross
Journal of Neuroscience 15 November 2001, 21 (22) 9018-9026; https://doi.org/10.1523/JNEUROSCI.21-22-09018.2001
Pam Blundell
1Department of Psychology, University of York, Heslington, York, YO10 5DD United Kingdom, and
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Geoffrey Hall
1Department of Psychology, University of York, Heslington, York, YO10 5DD United Kingdom, and
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Simon Killcross
2School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
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  • Fig. 1.
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    Fig. 1.

    Schematic representation of excitotoxic lesions to the basolateral amygdala from experiment 1. Shaded areasrepresent the smallest (black) and largest (gray) extent of neuronal damage. Coronal sections are −1.8 to −3.8 mm relative to bregma (Swanson, 1998).

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    Fig. 2.

    Acquisition of a conditional instrumental discrimination in sham-lesioned (left) and BLA-lesioned (right) rats. Closed symbols indicate consistent groups; open symbols indicate inconsistent groups; circles indicate correct responses;squares indicate incorrect responses. Bars represent 2 SEs of the differences between means (SED) derived from the appropriate ANOVA term and may be used as a guide to variability.

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    Fig. 3.

    Group mean difference scores (total correct − incorrect responses) during the extinction test session of experiment 1. Bars represent 2 SED.

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    Fig. 4.

    Group mean difference scores of responses during the “outcomes only” session of experiment 1, in which no discriminative stimuli were presented. Bars represent 2 SED.

  • Fig. 5.
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    Fig. 5.

    Schematic representation of excitotoxic lesions to the basolateral amygdala from experiment 2. Shaded areasrepresent the smallest (black) and largest (gray) extent of neuronal damage. Coronal sections are −1.8 to −3.8 mm relative to bregma (Swanson, 1998).

  • Fig. 6.
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    Fig. 6.

    Group mean response rates during presentation of a CS and during the baseline (no CS) period from extinction test sessions of experiment 2. Bars represent 2 SED.

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    Fig. 7.

    Group mean elevation ratios for “same” and “different” responses in experiment 2 (see Results for details). Bars represent 2 SED.

Tables

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    Table 1.

    Contingencies in experiment 1 examining the differential outcomes effect

    S1S2
    ConsistentR1 → O1R1 → ∅
    R2 → ∅R2 → O2
    InconsistentR1 → O1/O2R1 → ∅
    R2 → ∅R2 → O1/O2
    • R1 and R2 are left and right lever presses, O1 and O2 are sucrose and food pellet reinforcers, and S1 and S2 are tone and click-train. ∅ indicates no reward (see Materials and Methods; experiment 1).

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The Journal of Neuroscience: 21 (22)
Journal of Neuroscience
Vol. 21, Issue 22
15 Nov 2001
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Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats
Pam Blundell, Geoffrey Hall, Simon Killcross
Journal of Neuroscience 15 November 2001, 21 (22) 9018-9026; DOI: 10.1523/JNEUROSCI.21-22-09018.2001

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Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats
Pam Blundell, Geoffrey Hall, Simon Killcross
Journal of Neuroscience 15 November 2001, 21 (22) 9018-9026; DOI: 10.1523/JNEUROSCI.21-22-09018.2001
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Keywords

  • appetitive conditioning
  • basolateral amygdala
  • reward
  • reinforcement
  • pavlovian
  • instrumental

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