Article Figures & Data
Figures
- Fig. 1.
Brain images of the distribution volume of [11C]d-threo-methylphenidate in a control and a METH abuser. Images shown were obtained at the level of the striatum (images to the left) and the cerebellum (images to the right), and they are from a normal control and a METH abuser evaluated twice, during short and protracted abstinence. Notice the significant increases in binding in striatum in the METH abuser with protracted abstinence.
- Fig. 2.
Individual measures for DAT availability in the five METH abusers tested twice during short and protracted abstinence. Measures of DAT availability (Bmax/Kd) were significantly increased with protracted abstinence in caudate (p < 0.003) and putamen (p < 0.05). Repeated-measures ANOVA.
- Fig. 3.
A, Correlation between changes in DAT in putamen between the first and second evaluations and the reported doses (r = 0.88; df = 4;p < 0.05) and years of METH used (r = 0.83; df = 4; p < 0.08). B, Correlation between changes in DAT in striatum between the first and second evaluations and the days elapsed between evaluations (r = 0.92; df = 4;p < 0.05).
Tables
- Table 1.
Measures of K1 and DAT availability in controls and methamphetamine abusers evaluated during short or protracted abstinence
Controls (n = 11) METH abusers (short abstinence) (n = 12) METH abusers (protracted abstinence) (n = 10) K1 Cerebellum 0.42 ± 0.11 0.48 ± 0.17 0.46 ± 0.11 Caudate 0.58 ± 0.12 0.63 ± 0.18 0.55 ± 0.07 Putamen 0.64 ± 0.14 0.73 ± 0.24 0.62 ± 0.08 Bmax/Kd Caudate 1.76 ± 0.27 1.32 ± 0.28* 1.67 ± 0.291-160 Putamen 1.97 ± 0.21 1.56 ± 0.30* 1.80 ± 0.35 The K1 (transfer constant of [11C]d-threo-methylphenidate from plasma to brain) and Bmax/Kd(measure of DAT availability) were measured in 11 controls, 12 METH abusers evaluated during short abstinence (64 ± 40 d of abstinence), and 10 METH abusers evaluated during protracted abstinence (15 ± 7 months of abstinence). Note that the data for the five METH abusers tested twice was included in this group analysis: the data obtained during the first evaluation as part of the group tested during short abstinence and the data obtained during the second evaluation as part of the group tested during protracted abstinence. Factorial ANOVA showed that the group differences were significant forBmax/Kd in caudate (p < 0.002) and putamen (p < 0.01).Post hoc t tests;
↵* p < 0.003, different from controls;
↵F1-160 p < 0.01, different from short abstinence.
