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ARTICLE, Cellular/Molecular

Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy

R. H. Christie, B. J. Bacskai, W. R. Zipfel, R. M. Williams, S. T. Kajdasz, W. W. Webb and B. T. Hyman
Journal of Neuroscience 1 February 2001, 21 (3) 858-864; DOI: https://doi.org/10.1523/JNEUROSCI.21-03-00858.2001
R. H. Christie
1Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
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B. J. Bacskai
1Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
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W. R. Zipfel
2School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853
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R. M. Williams
2School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853
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S. T. Kajdasz
1Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
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W. W. Webb
2School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853
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B. T. Hyman
1Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-03-00858.2001
PubMed 
11157072
Published By 
Society for Neuroscience
History 
  • Received August 14, 2000
  • Revision received November 3, 2000
  • Accepted November 13, 2000
  • First published February 1, 2001.
  • Version of record published February 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. R. H. Christie1,
  2. B. J. Bacskai1,
  3. W. R. Zipfel2,
  4. R. M. Williams2,
  5. S. T. Kajdasz1,
  6. W. W. Webb2, and
  7. B. T. Hyman1
  1. 1Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
  2. 2School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853
View Full Text

Author contributions

Disclosures

    • Received August 14, 2000.
    • Revision received November 3, 2000.
    • Accepted November 13, 2000.
  • This work was supported by National Institute on Aging Grants AG08487, P01 AG15453, and T32GM07753, as well as generous support from the Walters Family Foundation.

    Correspondence should be addressed to Dr. Bradley Hyman, Alzheimer's Disease Research Unit, CNY 6405, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129. E-mail:B_Hyman{at}helix.mgh.harvard.edu.

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The Journal of Neuroscience: 21 (3)
Journal of Neuroscience
Vol. 21, Issue 3
1 Feb 2001
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Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy
R. H. Christie, B. J. Bacskai, W. R. Zipfel, R. M. Williams, S. T. Kajdasz, W. W. Webb, B. T. Hyman
Journal of Neuroscience 1 February 2001, 21 (3) 858-864; DOI: 10.1523/JNEUROSCI.21-03-00858.2001

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Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy
R. H. Christie, B. J. Bacskai, W. R. Zipfel, R. M. Williams, S. T. Kajdasz, W. W. Webb, B. T. Hyman
Journal of Neuroscience 1 February 2001, 21 (3) 858-864; DOI: 10.1523/JNEUROSCI.21-03-00858.2001
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Keywords

  • amyloid
  • transgenic
  • Alzheimer
  • two-photon
  • in vivo imaging
  • senile plaque
  • microglia

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