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ARTICLE, Cellular/Molecular

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Colin K. Combs, J. Colleen Karlo, Shih-Chu Kao and Gary E. Landreth
Journal of Neuroscience 15 February 2001, 21 (4) 1179-1188; https://doi.org/10.1523/JNEUROSCI.21-04-01179.2001
Colin K. Combs
1Alzheimer Research Laboratory, Departments of Neurosciences and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
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J. Colleen Karlo
1Alzheimer Research Laboratory, Departments of Neurosciences and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
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Shih-Chu Kao
1Alzheimer Research Laboratory, Departments of Neurosciences and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
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Gary E. Landreth
1Alzheimer Research Laboratory, Departments of Neurosciences and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-04-01179.2001
PubMed 
11160388
Published By 
Society for Neuroscience
History 
  • Received July 5, 2000
  • Revision received December 1, 2000
  • Accepted December 7, 2000
  • First published February 15, 2001.
  • Version of record published February 15, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. Colin K. Combs,
  2. J. Colleen Karlo,
  3. Shih-Chu Kao, and
  4. Gary E. Landreth
  1. 1Alzheimer Research Laboratory, Departments of Neurosciences and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
View Full Text

Author contributions

Disclosures

    • Received July 5, 2000.
    • Revision received December 1, 2000.
    • Accepted December 7, 2000.
  • This work was supported by grants from National Institutes of Health (AG08012 and AG16740) to G.L. and the Blachett Hooker Rockefeller Foundation. C.C. was supported by a training grant from National Institutes of Health (HD0710422). The TNFα construct was a generous gift from Dr. Andre Nel. We thank Dr. Michael Heneka for his comments on this manuscript and Dr. Mark Smith for useful discussion.

    Correspondence should be addressed to Dr. Gary Landreth, Alzheimer Research Laboratory, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106. E-mail:gel2{at}po.cwru.edu.

    Dr. Combs's present address: Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203.

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The Journal of Neuroscience: 21 (4)
Journal of Neuroscience
Vol. 21, Issue 4
15 Feb 2001
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β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
Colin K. Combs, J. Colleen Karlo, Shih-Chu Kao, Gary E. Landreth
Journal of Neuroscience 15 February 2001, 21 (4) 1179-1188; DOI: 10.1523/JNEUROSCI.21-04-01179.2001

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β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
Colin K. Combs, J. Colleen Karlo, Shih-Chu Kao, Gary E. Landreth
Journal of Neuroscience 15 February 2001, 21 (4) 1179-1188; DOI: 10.1523/JNEUROSCI.21-04-01179.2001
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Keywords

  • Alzheimer's disease
  • β-amyloid
  • microglia
  • THP-1 monocytes
  • signal transduction
  • tyrosine kinase
  • Lyn
  • Syk
  • inflammation
  • neurotoxicity
  • apoptosis
  • nitric oxide
  • nitrotyrosine
  • peroxynitrite
  • TNFα
  • cytokines

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