Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury

This work was supported by National Institutes of Health (NIH) Grant NS 01855 to S.A.B., NIH Grant P30 HD 33703, Oregon Child Health Research Center, Training Program Award for Pediatric Physician-Scientists to S.A.B., NIH–National Institute of Child Health and Human Development Grant P30 HD 18655 to J.J.V., a Grass Foundation Morison Fellowship and a Hearst Foundation Award to S.A.B., and an award from the Sudden Infant Death Syndrome Alliance to H.C.K. We gratefully acknowledge the support of Drs. Linda Wallen, Randall Nixon, and Geoffrey Murdoch at Oregon Health Sciences University and the NIH Developmental Brain and Tissue Bank at the University of Miami under the direction of Dr. Carol Petito (NO1-HD-8-3284) for their support in the acquisition of cases. We also thank Drs. Edward G. Jones, Gregory Popken, and Clifford Saper for guidance on the morphometric studies, Dr. Peter Rotwein for the generous use of his microscope, and Dr. Gary Sexton for generous assistance with statistical analysis. We are grateful to Drs. Julie Ellison, John Fiala, Jonathan Flax, Montey Gates, John Kornhauser, Jeffrey Macklis, Akiko Nishiyama, Steven Pfeiffer, Scott Pomeroy, and Wolfgang Streit for their helpful advice and discussions. We thank Luciana Rava and Richard Belliveau for their excellent technical assistance.

Correspondence should be addressed to Dr. Stephen A. Back, Department of Pediatrics, Hatfield Research Center, Room 516, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201-3098. E-mail: Backs{at}ohsu.edu.