Antisense Knockdown of the Glial Glutamate Transporter GLT-1, But Not the Neuronal Glutamate Transporter EAAC1, Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

Vemuganti L. Raghavendra Rao; Aclan Dogan; Kathryn G. Todd; Kellie K. Bowen; Bum-Tae Kim; Jeffrey D. Rothstein; Robert J. Dempsey

doi:10.1523/JNEUROSCI.21-06-01876.2001

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.21-06-01876.2001

PubMed

11245672

Published By

Society for Neuroscience

History

Received July 12, 2000
Revision received December 29, 2000
Accepted January 2, 2001
First published March 15, 2001.

Version of record published March 15, 2001.

Author Information

Vemuganti L. Raghavendra Rao1,2,
Aclan Dogan1,
Kathryn G. Todd4,
Kellie K. Bowen1,
Bum-Tae Kim1,5,
Jeffrey D. Rothstein6, and
Robert J. Dempsey1,3

¹Department of Neurological Surgery and
²Cardiovascular Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53792,
³William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin 53792,
⁴Department of Psychiatry, University of Alberta, Edmonton, Canada T6G 2B7,
⁵Department of Neurosurgery, Soonchunhyang University Hospital, Seoul, Korea, and
⁶Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287

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Author contributions

Disclosures

Received July 12, 2000.
Revision received December 29, 2000.
Accepted January 2, 2001.

This work was supported by American Heart Association National Grant 9950086N, American Heart Association Wisconsin Affiliate Grant 9806376X, the University of Wisconsin (UW)-Madison Medical School Research Committee Grant 161-9587, and the Department of Neurological Surgery UW-Madison Start-up Grant to V.L.R.R., National Institutes of Health Grants NS28000 and NS31220 to R.J.D., and a Korean Research Foundation grant to B.-T.K. We thank Dr. Peter Lipton (University of Wisconsin-Madison) for comments and suggestions.
Correspondence should be addressed to Dr. Vemuganti L. R. Rao, Department of Neurological Surgery, University of Wisconsin-Madison, F4/309 CSC, 600 Highland Avenue, Madison, WI 53792. E-mail:Vemugant{at}neurosurg.wisc.edu.

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	Abstract	Full	Pdf
Mar 2001	457	571	532
Apr 2001	39	110	82
May 2001	31	94	65
Jun 2001	12	34	11
Jul 2001	8	67	49
Aug 2001	12	50	35
Sep 2001	3	30	20
Oct 2001	5	69	38
Nov 2001	3	36	23
Dec 2001	5	70	44
Total 2001	575	1131	899
Jan 2002	5	48	23
Feb 2002	3	22	11
Mar 2002	6	25	11
Apr 2002	4	38	33
May 2002	2	24	33
Jun 2002	0	19	15
Jul 2002	4	24	23
Aug 2002	4	19	22
Sep 2002	0	34	23
Oct 2002	5	37	32
Nov 2002	5	35	20
Dec 2002	0	25	13
Total 2002	38	350	259
Jan 2003	5	25	20
Feb 2003	3	19	18
Mar 2003	3	39	33
Apr 2003	0	16	7
May 2003	5	18	19
Jun 2003	2	22	30
Jul 2003	6	29	15
Aug 2003	9	30	21
Sep 2003	7	54	38
Oct 2003	12	27	16
Nov 2003	20	42	25
Dec 2003	18	35	23
Total 2003	90	356	265
Jan 2004	19	31	17
Feb 2004	15	27	12
Mar 2004	21	39	25
Apr 2004	25	34	18
May 2004	27	52	10
Jun 2004	23	64	20
Jul 2004	15	22	14
Aug 2004	29	55	17
Sep 2004	35	43	10
Oct 2004	26	44	37
Nov 2004	18	36	23
Dec 2004	17	23	10
Total 2004	270	470	213
Jan 2005	18	35	31
Feb 2005	20	38	25
Mar 2005	18	50	37
Apr 2005	3	30	17
May 2005	13	25	17
Jun 2005	10	22	12
Jul 2005	3	27	15
Aug 2005	10	16	8
Sep 2005	5	18	12
Oct 2005	12	26	19
Nov 2005	7	25	16
Dec 2005	12	12	10
Total 2005	131	324	219
Jan 2006	3	33	10
Feb 2006	4	31	23
Mar 2006	12	21	12
Apr 2006	15	28	14
May 2006	3	18	15
Jun 2006	10	15	11
Jul 2006	11	12	9
Aug 2006	8	9	8
Sep 2006	7	16	14
Oct 2006	8	23	18
Nov 2006	8	15	18
Dec 2006	10	11	10
Total 2006	99	232	162
Jan 2007	13	13	10
Feb 2007	6	17	11
Mar 2007	5	15	9
Apr 2007	6	15	24
May 2007	8	14	13
Jun 2007	4	14	10
Jul 2007	2	9	8
Aug 2007	2	13	8
Sep 2007	8	10	7
Oct 2007	6	17	13
Nov 2007	5	23	11
Dec 2007	1	14	9
Total 2007	66	174	133
Jan 2008	8	20	11
Feb 2008	7	15	14
Mar 2008	7	14	13
Apr 2008	6	14	14
May 2008	14	15	13
Jun 2008	3	1	4
Jul 2008	6	17	22
Aug 2008	4	9	5
Sep 2008	25	38	10
Oct 2008	17	20	14
Nov 2008	15	14	6
Dec 2008	7	8	9
Total 2008	119	185	135
Jan 2009	5	15	8
Feb 2009	12	18	15
Mar 2009	15	12	11
Apr 2009	5	7	9
May 2009	8	13	14
Jun 2009	10	15	11
Jul 2009	7	17	5
Aug 2009	4	8	6
Sep 2009	6	6	11
Oct 2009	10	8	8
Nov 2009	14	13	6
Dec 2009	10	9	11
Total 2009	106	141	115
Jan 2010	11	12	14
Feb 2010	8	11	10
Mar 2010	10	21	12
Apr 2010	17	7	8
May 2010	14	18	13
Jun 2010	4	7	3
Jul 2010	3	9	7
Aug 2010	7	14	10
Sep 2010	6	17	10
Oct 2010	12	21	10
Nov 2010	4	14	5
Dec 2010	10	12	9
Total 2010	106	163	111
Jan 2011	10	16	9
Feb 2011	15	13	20
Mar 2011	16	13	9
Apr 2011	24	10	12
May 2011	11	25	19
Jun 2011	9	16	13
Jul 2011	6	13	15
Aug 2011	22	9	15
Sep 2011	14	11	10
Oct 2011	40	18	18
Nov 2011	17	15	11
Dec 2011	18	7	17
Total 2011	202	166	168
Jan 2012	25	24	28
Feb 2012	27	27	19
Mar 2012	23	19	22
Apr 2012	21	17	25
May 2012	39	12	10
Jun 2012	26	16	14
Jul 2012	20	10	11
Aug 2012	28	12	13
Sep 2012	13	3	5
Oct 2012	42	8	14
Nov 2012	35	13	27
Dec 2012	42	3	13
Total 2012	341	164	201
Jan 2013	15	6	13
Feb 2013	16	11	16
Mar 2013	34	20	26
Apr 2013	9	14	22
May 2013	15	12	16
Jun 2013	13	6	10
Jul 2013	16	9	15
Aug 2013	20	5	6
Sep 2013	16	4	14
Oct 2013	15	7	10
Nov 2013	15	13	21
Dec 2013	9	7	11
Total 2013	193	114	180
Jan 2014	20	4	14
Feb 2014	7	15	16
Mar 2014	12	10	23
Apr 2014	12	12	10
May 2014	14	4	6
Jun 2014	25	8	11
Jul 2014	9	5	7
Aug 2014	13	9	11
Sep 2014	16	20	11
Oct 2014	15	5	14
Nov 2014	8	3	2
Dec 2014	13	7	9
Total 2014	164	102	134
Jan 2015	11	10	11
Feb 2015	6	14	3
Mar 2015	19	11	9
Apr 2015	7	7	11
May 2015	5	12	9
Jun 2015	8	7	3
Jul 2015	18	2	4
Aug 2015	8	5	5
Sep 2015	5	7	6
Oct 2015	11	9	5
Nov 2015	17	6	5
Dec 2015	17	15	5
Total 2015	132	105	76
Jan 2016	68	11	13
Feb 2016	25	13	18
Mar 2016	15	7	12
Apr 2016	8	7	11
May 2016	13	8	7
Jun 2016	3	7	12
Jul 2016	23	2	9
Aug 2016	11	7	6
Sep 2016	4	2	6
Oct 2016	4	6	4
Nov 2016	2	6	16
Dec 2016	4	9	8
Total 2016	180	85	122
Jan 2017	4	11	4
Feb 2017	3	7	4
Mar 2017	2	18	7
Apr 2017	4	10	4
May 2017	4	34	7
Jun 2017	4	10	6
Jul 2017	0	4	4
Aug 2017	0	7	6
Sep 2017	1	0	6
Oct 2017	5	4	4
Nov 2017	13	13	10
Dec 2017	2	8	5
Total 2017	42	126	67
Jan 2018	5	6	8
Feb 2018	5	11	11
Mar 2018	6	9	11
Apr 2018	9	19	23
May 2018	11	19	20
Jun 2018	11	23	12
Jul 2018	9	10	3
Aug 2018	5	10	4
Sep 2018	2	16	3
Oct 2018	4	17	2
Nov 2018	1	21	11
Dec 2018	2	8	8
Total 2018	70	169	116
Jan 2019	6	8	12
Feb 2019	4	13	18
Mar 2019	2	12	6
Apr 2019	7	6	7
May 2019	6	12	9
Jun 2019	4	11	8
Jul 2019	5	3	11
Aug 2019	7	30	14
Sep 2019	3	37	2
Oct 2019	5	48	15
Nov 2019	6	13	9
Dec 2019	6	17	12
Total 2019	61	210	123
Jan 2020	5	11	7
Feb 2020	4	8	8
Mar 2020	4	6	1
Apr 2020	0	11	4
May 2020	2	11	6
Jun 2020	5	11	10
Jul 2020	5	7	13
Aug 2020	3	2	5
Sep 2020	4	9	8
Oct 2020	3	17	4
Nov 2020	6	15	11
Dec 2020	1	9	0
Total 2020	42	117	77
Jan 2021	2	16	14
Feb 2021	11	14	7
Mar 2021	3	21	14
Apr 2021	6	15	7
May 2021	10	21	12
Jun 2021	1	22	5
Jul 2021	2	12	20
Aug 2021	7	20	12
Sep 2021	5	17	7
Oct 2021	2	12	23
Nov 2021	2	15	22
Dec 2021	7	16	9
Total 2021	58	201	152
Jan 2022	2	15	7
Feb 2022	2	17	4
Mar 2022	3	14	9
Apr 2022	3	17	4
May 2022	2	9	11
Total 2022	12	72	35
Total	3097	5157	3962