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ARTICLE, Behavioral/Systems

Predictability Modulates Human Brain Response to Reward

Gregory S. Berns, Samuel M. McClure, Giuseppe Pagnoni and P. Read Montague
Journal of Neuroscience 15 April 2001, 21 (8) 2793-2798; DOI: https://doi.org/10.1523/JNEUROSCI.21-08-02793.2001
Gregory S. Berns
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Samuel M. McClure
2Center for Theoretical Neuroscience, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
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Giuseppe Pagnoni
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, and
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P. Read Montague
2Center for Theoretical Neuroscience, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
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Abstract

Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.

  • reward
  • dopamine
  • fMRI
  • reinforcement
  • neural network
  • nucleus accumbens
  • striatum
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The Journal of Neuroscience: 21 (8)
Journal of Neuroscience
Vol. 21, Issue 8
15 Apr 2001
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Predictability Modulates Human Brain Response to Reward
Gregory S. Berns, Samuel M. McClure, Giuseppe Pagnoni, P. Read Montague
Journal of Neuroscience 15 April 2001, 21 (8) 2793-2798; DOI: 10.1523/JNEUROSCI.21-08-02793.2001

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Predictability Modulates Human Brain Response to Reward
Gregory S. Berns, Samuel M. McClure, Giuseppe Pagnoni, P. Read Montague
Journal of Neuroscience 15 April 2001, 21 (8) 2793-2798; DOI: 10.1523/JNEUROSCI.21-08-02793.2001
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Keywords

  • reward
  • dopamine
  • fMRI
  • reinforcement
  • neural network
  • nucleus accumbens
  • striatum

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