Identification of Amino Acid Residues in GluR1 Responsible for Ligand Binding and Desensitization

This work was supported by Grants 9700761, 9900010, and 9900201 from the Danish Medical Research Council, by the Lundbeck, Alfred Benzon, and Novo Nordisk Foundations, and by the National Institutes of Health, National Institute of Neurological Disorders and Stroke. We thank Dr. D. Bowie for discussions and critical reading of the manuscript. We also thank Dr. Ulf Madsen for generously supplying us with (R,S)-4-bromohomoibotenic acid.

Correspondence should be addressed to Dr. Darryl S. Pickering, Department of Pharmacology, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100 Copenhagen, Denmark. E-mail:picker{at}dfh.dk.