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ARTICLE, Development/Plasticity/Repair

Motoneuron Survival Is Enhanced in the Absence of Neuromuscular Junction Formation in Embryos

J. Terrado, R. W. Burgess, T. DeChiara, G. Yancopoulos, J. R. Sanes and A. C. Kato
Journal of Neuroscience 1 May 2001, 21 (9) 3144-3150; https://doi.org/10.1523/JNEUROSCI.21-09-03144.2001
J. Terrado
1Division of Clinical Neuromuscular Research and Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Faculty of Medicine, Centre Médical Universitaire, 1211 Geneva 4, Switzerland,
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R. W. Burgess
2Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, Missouri 63110, and
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T. DeChiara
3Regeneron Pharmaceuticals, Tarrytown, New York 10591
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G. Yancopoulos
3Regeneron Pharmaceuticals, Tarrytown, New York 10591
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J. R. Sanes
2Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, Missouri 63110, and
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A. C. Kato
1Division of Clinical Neuromuscular Research and Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Faculty of Medicine, Centre Médical Universitaire, 1211 Geneva 4, Switzerland,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.21-09-03144.2001
PubMed 
11312299
Published By 
Society for Neuroscience
History 
  • Received October 9, 2000
  • Revision received February 5, 2001
  • Accepted February 8, 2001
  • First published May 1, 2001.
  • Version of record published May 1, 2001.
Copyright & Usage 
Copyright © 2001 Society for Neuroscience

Author Information

  1. J. Terrado1,
  2. R. W. Burgess2,
  3. T. DeChiara3,
  4. G. Yancopoulos3,
  5. J. R. Sanes2, and
  6. A. C. Kato1
  1. 1Division of Clinical Neuromuscular Research and Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Faculty of Medicine, Centre Médical Universitaire, 1211 Geneva 4, Switzerland,
  2. 2Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, Missouri 63110, and
  3. 3Regeneron Pharmaceuticals, Tarrytown, New York 10591
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Author contributions

Disclosures

    • Received October 9, 2000.
    • Revision received February 5, 2001.
    • Accepted February 8, 2001.
  • This work was supported by the Association Française contre les Myopathies (France) and the Swiss National Science Foundation (A.C.K. and J.T.), and by the National Institutes of Health (J.R.S. and R.W.B.). A Spanish version of this work has been awarded the Coris Gruart Prize to J.T. We thank B. King, D. Monnier, D. Perrelet, and R. Vejsada for their assistance throughout this work.

    Correspondence should be addressed to Ann Kato, Division of Clinical Neuromuscular Research and Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Centre Médical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. E-mail:Ann.Kato{at}medecine.unige.ch.

    Dr. Terrado's present address: Departamento de Medicina y Cirugı́a Animal. Facultad Ciencias Experimentales y de la Salud. Universidad Cardenal Herrera-CEU. 46113, Moncada-Valencia, Spain.

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The Journal of Neuroscience: 21 (9)
Journal of Neuroscience
Vol. 21, Issue 9
1 May 2001
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Motoneuron Survival Is Enhanced in the Absence of Neuromuscular Junction Formation in Embryos
J. Terrado, R. W. Burgess, T. DeChiara, G. Yancopoulos, J. R. Sanes, A. C. Kato
Journal of Neuroscience 1 May 2001, 21 (9) 3144-3150; DOI: 10.1523/JNEUROSCI.21-09-03144.2001

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Motoneuron Survival Is Enhanced in the Absence of Neuromuscular Junction Formation in Embryos
J. Terrado, R. W. Burgess, T. DeChiara, G. Yancopoulos, J. R. Sanes, A. C. Kato
Journal of Neuroscience 1 May 2001, 21 (9) 3144-3150; DOI: 10.1523/JNEUROSCI.21-09-03144.2001
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Keywords

  • motoneuron survival
  • neuromuscular junction formation
  • null mutant mice
  • rapsyn
  • MuSK
  • agrin

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