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ARTICLE, Cellular/Molecular

Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation

Taku Sugawara, Nobuo Noshita, Anders Lewén, Yvan Gasche, Michel Ferrand-Drake, Miki Fujimura, Yuiko Morita-Fujimura and Pak H. Chan
Journal of Neuroscience 1 January 2002, 22 (1) 209-217; https://doi.org/10.1523/JNEUROSCI.22-01-00209.2002
Taku Sugawara
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Nobuo Noshita
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Anders Lewén
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Yvan Gasche
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Michel Ferrand-Drake
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Miki Fujimura
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Yuiko Morita-Fujimura
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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Pak H. Chan
1Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, California 94305
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The Journal of Neuroscience: 22 (1)
Journal of Neuroscience
Vol. 22, Issue 1
1 Jan 2002
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Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation
Taku Sugawara, Nobuo Noshita, Anders Lewén, Yvan Gasche, Michel Ferrand-Drake, Miki Fujimura, Yuiko Morita-Fujimura, Pak H. Chan
Journal of Neuroscience 1 January 2002, 22 (1) 209-217; DOI: 10.1523/JNEUROSCI.22-01-00209.2002

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Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation
Taku Sugawara, Nobuo Noshita, Anders Lewén, Yvan Gasche, Michel Ferrand-Drake, Miki Fujimura, Yuiko Morita-Fujimura, Pak H. Chan
Journal of Neuroscience 1 January 2002, 22 (1) 209-217; DOI: 10.1523/JNEUROSCI.22-01-00209.2002
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Keywords

  • superoxide dismutase
  • oxidative stress
  • global cerebral ischemia
  • neuron
  • apoptosis
  • cytochrome c
  • second mitochondrial activator of caspases
  • caspase

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