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ARTICLE, Behavioral/Systems

μ-Opioid Receptors: Ligand-Dependent Activation of Potassium Conductance, Desensitization, and Internalization

Veronica A. Alvarez, Seksiri Arttamangkul, Vu Dang, Abdallah Salem, Jennifer L. Whistler, Mark von Zastrow, David K. Grandy and John T. Williams
Journal of Neuroscience 1 July 2002, 22 (13) 5769-5776; https://doi.org/10.1523/JNEUROSCI.22-13-05769.2002
Veronica A. Alvarez
1Vollum Institute and
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Seksiri Arttamangkul
2Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, Oregon 97201,
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Vu Dang
1Vollum Institute and
2Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, Oregon 97201,
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Abdallah Salem
1Vollum Institute and
3Department of Clinical and Experimental Pharmacology, Adelaide University, Adelaide SA 5005, Australia,
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Jennifer L. Whistler
4Ernest Gallo Clinic and Research Center, Emeryville, California 94608, and
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Mark von Zastrow
5Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143
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David K. Grandy
2Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, Oregon 97201,
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John T. Williams
1Vollum Institute and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-13-05769.2002
PubMed 
12097530
Published By 
Society for Neuroscience
History 
  • Received February 19, 2002
  • Revision received April 17, 2002
  • Accepted April 18, 2002
  • First published July 1, 2002.
  • Version of record published July 1, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Veronica A. Alvarez1,*,
  2. Seksiri Arttamangkul2,*,
  3. Vu Dang1,2,
  4. Abdallah Salem1,3,
  5. Jennifer L. Whistler4,
  6. Mark von Zastrow5,
  7. David K. Grandy2, and
  8. John T. Williams1
  1. 1Vollum Institute and
  2. 2Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, Oregon 97201,
  3. 3Department of Clinical and Experimental Pharmacology, Adelaide University, Adelaide SA 5005, Australia,
  4. 4Ernest Gallo Clinic and Research Center, Emeryville, California 94608, and
  5. 5Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143
View Full Text

Author contributions

Disclosures

    • Received February 19, 2002.
    • Revision received April 17, 2002.
    • Accepted April 18, 2002.
  • ↵* V.A.A. and S.A. contributed equally to this work.

  • This work was supported by National Institutes of Health Grants DA08163 (J.T.W.), DA07262 (S.A.), DA12864 (M.v.Z.), and DA08562 and DA10703 (D.K.G.). We thank Drs. Amara and Watt for the use of the confocal microscope and Drs. Torrecilla and Morikawa for comments on this work.

  • Correspondence should be addressed to John T. Williams, Vollum Institute, L474 Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201. E-mail williamj{at}ohsu.edu.

  • V. A. Alvarez's present address: Department of Neurobiology, Harvard Medical School, Boston, MA 02115.

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Total4032981939
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The Journal of Neuroscience: 22 (13)
Journal of Neuroscience
Vol. 22, Issue 13
1 Jul 2002
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μ-Opioid Receptors: Ligand-Dependent Activation of Potassium Conductance, Desensitization, and Internalization
Veronica A. Alvarez, Seksiri Arttamangkul, Vu Dang, Abdallah Salem, Jennifer L. Whistler, Mark von Zastrow, David K. Grandy, John T. Williams
Journal of Neuroscience 1 July 2002, 22 (13) 5769-5776; DOI: 10.1523/JNEUROSCI.22-13-05769.2002

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μ-Opioid Receptors: Ligand-Dependent Activation of Potassium Conductance, Desensitization, and Internalization
Veronica A. Alvarez, Seksiri Arttamangkul, Vu Dang, Abdallah Salem, Jennifer L. Whistler, Mark von Zastrow, David K. Grandy, John T. Williams
Journal of Neuroscience 1 July 2002, 22 (13) 5769-5776; DOI: 10.1523/JNEUROSCI.22-13-05769.2002
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Keywords

  • opioids
  • locus ceruleus
  • homologous desensitization
  • endocytosis
  • electrophysiology
  • imaging

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