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Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli and Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: https://doi.org/10.1523/JNEUROSCI.22-15-06321.2002
Marcello Solinas
1Sections of Preclinical Pharmacology and
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Sergi Ferré
1Sections of Preclinical Pharmacology and
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Zhi-Bing You
2Behavioral Neuroscience, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, and
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Marzena Karcz-Kubicha
1Sections of Preclinical Pharmacology and
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Patrizia Popoli
3Department of Pharmacology, Istituto Superiore di Sanita, 00161 Rome, Italy
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Steven R. Goldberg
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Abstract

An increase in the extracellular concentration of dopamine in the nucleus accumbens (NAc) is believed to be one of the main mechanisms involved in the rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. Using in vivo microdialysis in freely moving rats, we demonstrate that systemic administration of behaviorally relevant doses of caffeine can preferentially increase extracellular levels of dopamine and glutamate in the shell of the NAc. These effects could be reproduced by the administration of a selective adenosine A1 receptor antagonist but not by a selective adenosine A2A receptor antagonist. This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages.

  • caffeine
  • adenosine
  • dopamine
  • glutamate
  • accumbens
  • microdialysis
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The Journal of Neuroscience: 22 (15)
Journal of Neuroscience
Vol. 22, Issue 15
1 Aug 2002
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Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: 10.1523/JNEUROSCI.22-15-06321.2002

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Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: 10.1523/JNEUROSCI.22-15-06321.2002
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Keywords

  • caffeine
  • adenosine
  • dopamine
  • glutamate
  • accumbens
  • microdialysis

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