Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Marcello Solinas; Sergi Ferré; Zhi-Bing You; Marzena Karcz-Kubicha; Patrizia Popoli; Steven R. Goldberg

doi:10.1523/JNEUROSCI.22-15-06321.2002

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.22-15-06321.2002

PubMed

12151508

Published By

Society for Neuroscience

History

Received February 11, 2002
Revision received May 2, 2002
Accepted May 10, 2002
First published August 1, 2002.

Version of record published August 1, 2002.

Author Information

Marcello Solinas1,
Sergi Ferré1,
Zhi-Bing You2,
Marzena Karcz-Kubicha1,
Patrizia Popoli3, and
Steven R. Goldberg1

¹Sections of Preclinical Pharmacology and
²Behavioral Neuroscience, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, and
³Department of Pharmacology, Istituto Superiore di Sanita, 00161 Rome, Italy

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Author contributions

Disclosures

Received February 11, 2002.
Revision received May 2, 2002.
Accepted May 10, 2002.

This work was supported by the Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health.
Correspondence should be addressed to Dr. Steven R. Goldberg, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Behavioral Neuroscience Branch, Preclinical Pharmacology Section, 5500 Nathan Shock Drive, Baltimore, MD 21224. E-mail: sgoldber{at}intra.nida.nih.gov.

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	Abstract	Full	Pdf
Jul 2002	35	8	32
Aug 2002	734	301	629
Sep 2002	47	98	107
Oct 2002	29	97	72
Nov 2002	11	64	57
Dec 2002	5	37	34
Total 2002	861	605	931
Jan 2003	7	44	26
Feb 2003	2	39	22
Mar 2003	12	34	29
Apr 2003	7	58	43
May 2003	9	42	21
Jun 2003	9	34	23
Jul 2003	14	37	26
Aug 2003	9	22	16
Sep 2003	13	30	21
Oct 2003	15	53	32
Nov 2003	13	87	34
Dec 2003	8	26	18
Total 2003	118	506	311
Jan 2004	14	35	24
Feb 2004	14	52	28
Mar 2004	17	68	31
Apr 2004	16	59	35
May 2004	15	79	14
Jun 2004	8	80	21
Jul 2004	25	45	16
Aug 2004	31	49	22
Sep 2004	17	69	30
Oct 2004	19	49	22
Nov 2004	22	85	28
Dec 2004	29	70	35
Total 2004	227	740	306
Jan 2005	12	51	26
Feb 2005	18	61	31
Mar 2005	27	50	24
Apr 2005	11	62	25
May 2005	16	67	34
Jun 2005	12	37	17
Jul 2005	23	51	39
Aug 2005	12	24	20
Sep 2005	22	35	16
Oct 2005	15	37	23
Nov 2005	18	73	30
Dec 2005	19	55	22
Total 2005	205	603	307
Jan 2006	9	55	25
Feb 2006	7	77	23
Mar 2006	16	48	20
Apr 2006	17	53	34
May 2006	16	49	28
Jun 2006	19	46	20
Jul 2006	8	23	13
Aug 2006	7	32	8
Sep 2006	9	35	27
Oct 2006	20	47	36
Nov 2006	12	43	30
Dec 2006	7	25	25
Total 2006	147	533	289
Jan 2007	12	17	21
Feb 2007	15	29	32
Mar 2007	15	52	43
Apr 2007	9	39	60
May 2007	8	45	50
Jun 2007	3	27	34
Jul 2007	4	25	17
Aug 2007	9	28	11
Sep 2007	7	32	26
Oct 2007	16	33	28
Nov 2007	21	52	47
Dec 2007	31	29	31
Total 2007	150	408	400
Jan 2008	17	27	29
Feb 2008	12	30	28
Mar 2008	32	28	33
Apr 2008	43	38	48
May 2008	27	40	40
Jun 2008	24	11	23
Jul 2008	30	28	32
Aug 2008	20	22	20
Sep 2008	33	31	37
Oct 2008	25	32	24
Nov 2008	27	27	39
Dec 2008	8	14	22
Total 2008	298	328	375
Jan 2009	12	20	48
Feb 2009	20	27	37
Mar 2009	40	40	84
Apr 2009	20	30	64
May 2009	20	38	46
Jun 2009	17	32	34
Jul 2009	6	35	34
Aug 2009	14	36	52
Sep 2009	14	33	57
Oct 2009	25	64	83
Nov 2009	29	69	108
Dec 2009	20	42	59
Total 2009	237	466	706
Jan 2010	20	34	140
Feb 2010	34	47	109
Mar 2010	39	44	123
Apr 2010	37	84	96
May 2010	18	54	85
Jun 2010	19	35	70
Jul 2010	9	63	100
Aug 2010	17	80	165
Sep 2010	19	58	108
Oct 2010	28	73	152
Nov 2010	37	59	127
Dec 2010	45	62	124
Total 2010	322	693	1399
Jan 2011	15	45	81
Feb 2011	23	52	94
Mar 2011	45	68	134
Apr 2011	57	64	182
May 2011	29	81	146
Jun 2011	15	58	113
Jul 2011	14	42	128
Aug 2011	22	99	123
Sep 2011	21	82	207
Oct 2011	35	125	268
Nov 2011	41	85	230
Dec 2011	30	67	184
Total 2011	347	868	1890
Jan 2012	20	64	204
Feb 2012	13	60	253
Mar 2012	38	112	247
Apr 2012	39	123	228
May 2012	30	71	224
Jun 2012	19	56	147
Jul 2012	24	62	152
Aug 2012	26	77	168
Sep 2012	55	82	169
Oct 2012	102	91	175
Nov 2012	119	121	251
Dec 2012	57	87	196
Total 2012	542	1006	2414
Jan 2013	57	69	174
Feb 2013	69	84	165
Mar 2013	64	104	222
Apr 2013	54	87	212
May 2013	34	104	235
Jun 2013	22	79	175
Jul 2013	23	65	185
Aug 2013	22	43	149
Sep 2013	57	88	207
Oct 2013	73	328	232
Nov 2013	52	122	206
Dec 2013	58	77	202
Total 2013	585	1250	2364
Jan 2014	31	54	167
Feb 2014	60	68	202
Mar 2014	36	88	242
Apr 2014	72	117	255
May 2014	44	90	229
Jun 2014	20	72	184
Jul 2014	35	99	203
Aug 2014	15	68	196
Sep 2014	52	89	239
Oct 2014	45	65	245
Nov 2014	59	148	312
Dec 2014	32	131	317
Total 2014	501	1089	2791
Jan 2015	43	141	294
Feb 2015	73	141	475
Mar 2015	81	137	439
Apr 2015	83	171	482
May 2015	93	127	426
Jun 2015	64	112	349
Jul 2015	83	129	354
Aug 2015	51	137	318
Sep 2015	85	154	427
Oct 2015	57	181	525
Nov 2015	117	218	432
Dec 2015	62	165	246
Total 2015	892	1813	4767
Jan 2016	52	128	251
Feb 2016	64	139	284
Mar 2016	76	167	255
Apr 2016	84	166	275
May 2016	111	152	225
Jun 2016	73	85	138
Jul 2016	35	75	144
Aug 2016	33	61	125
Sep 2016	56	250	399
Oct 2016	56	164	97
Nov 2016	76	183	70
Dec 2016	78	108	111
Total 2016	794	1678	2374
Jan 2017	80	192	125
Feb 2017	81	237	124
Mar 2017	85	282	126
Apr 2017	67	229	110
May 2017	65	133	113
Jun 2017	48	100	85
Jul 2017	25	78	97
Aug 2017	54	79	81
Sep 2017	42	69	119
Oct 2017	87	170	112
Nov 2017	74	162	126
Dec 2017	66	127	102
Total 2017	774	1858	1320
Jan 2018	52	106	111
Feb 2018	82	135	108
Mar 2018	69	169	91
Apr 2018	97	288	102
May 2018	72	152	86
Jun 2018	53	219	74
Jul 2018	151	162	51
Aug 2018	71	102	48
Sep 2018	42	136	66
Oct 2018	54	213	64
Nov 2018	72	182	78
Dec 2018	47	158	57
Total 2018	862	2022	936
Jan 2019	41	165	66
Feb 2019	56	204	76
Mar 2019	71	224	94
Apr 2019	75	264	80
May 2019	49	158	60
Jun 2019	40	184	74
Jul 2019	42	166	46
Aug 2019	26	196	86
Sep 2019	56	230	34
Oct 2019	61	281	46
Nov 2019	70	264	62
Dec 2019	59	238	47
Total 2019	646	2574	771
Jan 2020	28	230	32
Feb 2020	33	272	46
Mar 2020	39	287	38
Apr 2020	52	316	63
May 2020	42	324	87
Jun 2020	67	269	68
Jul 2020	23	449	56
Aug 2020	11	645	35
Sep 2020	67	790	50
Oct 2020	64	1029	80
Nov 2020	88	923	79
Dec 2020	57	967	61
Total 2020	571	6501	695
Jan 2021	43	521	64
Feb 2021	36	370	42
Mar 2021	45	377	79
Apr 2021	57	572	58
May 2021	36	305	94
Jun 2021	29	392	65
Jul 2021	26	315	74
Aug 2021	28	276	46
Sep 2021	40	415	61
Oct 2021	58	792	70
Nov 2021	32	987	44
Dec 2021	48	797	62
Total 2021	478	6119	759
Jan 2022	38	1263	21
Feb 2022	47	1327	53
Mar 2022	117	820	40
Apr 2022	39	771	68
May 2022	43	742	70
Jun 2022	28	461	29
Total 2022	312	5384	281
Total	9869	37044	26386