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BRIEF COMMUNICATION

Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli and Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: https://doi.org/10.1523/JNEUROSCI.22-15-06321.2002
Marcello Solinas
1Sections of Preclinical Pharmacology and
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Sergi Ferré
1Sections of Preclinical Pharmacology and
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Zhi-Bing You
2Behavioral Neuroscience, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, and
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Marzena Karcz-Kubicha
1Sections of Preclinical Pharmacology and
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Patrizia Popoli
3Department of Pharmacology, Istituto Superiore di Sanita, 00161 Rome, Italy
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Steven R. Goldberg
1Sections of Preclinical Pharmacology and
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    Fig. 1.

    Total horizontal motor activity after intraperitoneal administration of caffeine in habituated rats. The results represent means ± SEM of the accumulated motor activity counts during the first 60 min period of observation (n = 6 per group). Significant motor activation was obtained with caffeine in a dose of 10 mg/kg (CAFF 10) and caffeine in a dose of 30 mg/kg (CAFF 30). **p < 0.01 compared with the group treated with saline (SAL).CAFF 3 and CAFF 100indicate 3 and 100 mg/kg caffeine, respectively.

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    Fig. 2.

    Extracellular concentrations of dopamine (DA) and glutamate (Glu) in the shell of the NAc after intraperitoneal administration of saline or caffeine [3 (caff 3), 10 (caff 10), 30 (caff 30), or 100 (caff 100) mg/kg]. The results represent means ± SEM of the percentage of basal values of the extracellular concentrations of dopamine and glutamate (n = 6–8 per group). Basal values were the means of three values before drug administration. Caffeine at doses of 10 and 30 mg/kg but not at doses of 3 and 100 mg/kg significantly increased the extracellular levels of dopamine and glutamate (Student's pairedt test; only significant results of pretreatment vs post-treatment are shown).

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    Fig. 3.

    Extracellular concentrations of dopamine (DA) and glutamate (Glu) in the shell and core of the NAc after intraperitoneal administration of caffeine [30 mg/kg (caff 30)]. The results represent means ± SEM of the percentage of basal values of the extracellular concentrations of dopamine and glutamate (n = 6–8 per group). Basal values were the means of three values before drug administration. Caffeine (30 mg/kg) produced a significant increase in the extracellular concentration of dopamine, but not of glutamate, in the core of the NAc (Student's paired t test; only significant results of pretreatment vs post-treatment are shown). This effect was significantly different from that produced by 30 mg/kg caffeine in the shell of the NAc (interaction between area and treatment factors: p < 0.01 by repeated-measures ANOVA).

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    Fig. 4.

    Extracellular concentrations of dopamine (DA) and glutamate (Glu) in the shell of the NAc after intraperitoneal administration of the adenosine A1 receptor antagonist CPT (4.8 mg/kg) and the A2A receptor antagonist SCH 58261 (2 mg/kg). The results represent means ± SEM of the percentage of basal values of the extracellular concentrations of dopamine and glutamate (n = 6–7 per group). Basal values were the means of three values before drug administration. CPT but not SCH 58261 produced a significant increase in the extracellular concentrations of dopamine and glutamate (Student's pairedt test; only significant results of pretreatment vs post-treatment are shown).

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The Journal of Neuroscience: 22 (15)
Journal of Neuroscience
Vol. 22, Issue 15
1 Aug 2002
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Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: 10.1523/JNEUROSCI.22-15-06321.2002

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Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens
Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R. Goldberg
Journal of Neuroscience 1 August 2002, 22 (15) 6321-6324; DOI: 10.1523/JNEUROSCI.22-15-06321.2002
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Keywords

  • caffeine
  • adenosine
  • dopamine
  • glutamate
  • accumbens
  • microdialysis

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