Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

Linda A. Kotilinek; Brian Bacskai; Marcus Westerman; Takeshi Kawarabayashi; Linda Younkin; Bradley T. Hyman; Steven Younkin; Karen H. Ashe

doi:10.1523/JNEUROSCI.22-15-06331.2002

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.22-15-06331.2002

PubMed

12151510

Published By

Society for Neuroscience

History

Received April 1, 2002
Revision received May 10, 2002
Accepted May 20, 2002
First published August 1, 2002.

Version of record published August 1, 2002.

Author Information

Linda A. Kotilinek1,
Brian Bacskai2,
Marcus Westerman1,
Takeshi Kawarabayashi3,
Linda Younkin3,
Bradley T. Hyman2,
Steven Younkin3, and
Karen H. Ashe1

¹Departments of Neurology and Neuroscience, University of Minnesota, Minneapolis 55455,
²Department of Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and
³Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224

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Disclosures

Received April 1, 2002.
Revision received May 10, 2002.
Accepted May 20, 2002.

This work was supported by National Institutes of Health Grants AG15453 (K.H.A., B.T.H., S.Y.), NS33249 (K.H.A.), MH65465 (K.H.A.), and AG08687 (B.T.H.); by a Pioneer Award from the Alzheimer's Association (B.T.H.); and by The Walter Family Foundation (B.T.H.). We gratefully acknowledge Stefanie Schrump, Deirdre Cooper-Blacketer, Jennifer Perry, Aaron Guimaraes, Jennifer Lang, Jennifer Paulson, and Nardina Nash for their expertise and dedication testing mice in the water maze. We thank Megan McLellan and Steve Kajdasz for technical assistance with immunohistological procedures and Eugene Gnida for technical help performing ELISAs.
Correspondence should be addressed to Karen H. Ashe, Department of Neurology, Mayo Mail Code 295, 420 Delaware Street Southeast, Minneapolis, MN 55455. E-mail: hsiao005{at}umn.edu.
T. Kawarabayashi's present address: Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700-8558 Japan.

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	Abstract	Full	Pdf
Jul 2002	64	14	46
Aug 2002	1467	444	1265
Sep 2002	54	169	181
Oct 2002	50	135	127
Nov 2002	19	94	74
Dec 2002	22	53	46
Total 2002	1676	909	1739
Jan 2003	15	64	69
Feb 2003	14	70	60
Mar 2003	18	62	56
Apr 2003	11	73	51
May 2003	8	63	43
Jun 2003	7	35	39
Jul 2003	9	59	54
Aug 2003	13	40	44
Sep 2003	24	40	37
Oct 2003	23	70	64
Nov 2003	20	47	50
Dec 2003	20	54	45
Total 2003	182	677	612
Jan 2004	18	60	46
Feb 2004	16	40	41
Mar 2004	34	50	43
Apr 2004	20	51	40
May 2004	22	65	57
Jun 2004	18	69	51
Jul 2004	25	53	56
Aug 2004	42	78	32
Sep 2004	40	63	56
Oct 2004	26	73	40
Nov 2004	20	66	48
Dec 2004	24	53	32
Total 2004	305	721	542
Jan 2005	28	72	39
Feb 2005	40	58	52
Mar 2005	43	61	47
Apr 2005	17	75	58
May 2005	30	48	41
Jun 2005	19	47	27
Jul 2005	34	63	57
Aug 2005	28	62	50
Sep 2005	10	63	35
Oct 2005	22	89	49
Nov 2005	19	79	49
Dec 2005	16	69	47
Total 2005	306	786	551
Jan 2006	16	81	48
Feb 2006	13	55	37
Mar 2006	35	91	40
Apr 2006	21	93	58
May 2006	22	63	38
Jun 2006	15	47	23
Jul 2006	9	40	28
Aug 2006	18	47	29
Sep 2006	18	156	45
Oct 2006	36	105	46
Nov 2006	30	112	71
Dec 2006	28	72	39
Total 2006	261	962	502
Jan 2007	36	77	56
Feb 2007	34	76	47
Mar 2007	51	76	46
Apr 2007	43	106	55
May 2007	26	78	38
Jun 2007	17	72	38
Jul 2007	14	41	32
Aug 2007	20	44	33
Sep 2007	21	51	35
Oct 2007	38	64	51
Nov 2007	26	52	45
Dec 2007	21	56	41
Total 2007	347	793	517
Jan 2008	15	57	46
Feb 2008	37	64	47
Mar 2008	21	46	36
Apr 2008	27	57	44
May 2008	19	43	31
Jun 2008	32	68	43
Jul 2008	19	32	27
Aug 2008	31	42	19
Sep 2008	46	40	44
Oct 2008	29	39	38
Nov 2008	40	46	31
Dec 2008	17	56	31
Total 2008	333	590	437
Jan 2009	21	35	26
Feb 2009	32	153	31
Mar 2009	43	60	42
Apr 2009	44	53	44
May 2009	24	31	28
Jun 2009	16	36	31
Jul 2009	26	19	12
Aug 2009	13	18	16
Sep 2009	26	30	32
Oct 2009	29	24	24
Nov 2009	49	47	57
Dec 2009	33	31	34
Total 2009	356	537	377
Jan 2010	32	34	22
Feb 2010	28	43	29
Mar 2010	35	52	54
Apr 2010	28	37	20
May 2010	19	64	37
Jun 2010	26	39	43
Jul 2010	14	39	27
Aug 2010	16	27	21
Sep 2010	23	32	21
Oct 2010	22	38	24
Nov 2010	26	26	17
Dec 2010	31	34	27
Total 2010	300	465	342
Jan 2011	27	23	18
Feb 2011	28	25	21
Mar 2011	39	34	28
Apr 2011	35	18	29
May 2011	36	35	38
Jun 2011	25	33	29
Jul 2011	15	17	23
Aug 2011	23	23	25
Sep 2011	43	24	19
Oct 2011	54	33	25
Nov 2011	54	25	47
Dec 2011	35	33	26
Total 2011	414	323	328
Jan 2012	26	27	25
Feb 2012	29	32	28
Mar 2012	49	51	36
Apr 2012	46	37	26
May 2012	32	33	41
Jun 2012	18	19	15
Jul 2012	16	30	23
Aug 2012	20	20	30
Sep 2012	14	16	46
Oct 2012	47	32	58
Nov 2012	58	19	46
Dec 2012	41	12	27
Total 2012	396	328	401
Jan 2013	35	21	34
Feb 2013	41	17	34
Mar 2013	39	38	57
Apr 2013	50	22	45
May 2013	33	18	42
Jun 2013	24	14	24
Jul 2013	13	10	30
Aug 2013	17	23	32
Sep 2013	31	15	22
Oct 2013	38	30	39
Nov 2013	51	40	45
Dec 2013	50	17	41
Total 2013	422	265	445
Jan 2014	23	30	49
Feb 2014	28	20	47
Mar 2014	67	26	66
Apr 2014	71	50	84
May 2014	55	19	73
Jun 2014	39	17	59
Jul 2014	36	28	80
Aug 2014	19	10	81
Sep 2014	67	21	49
Oct 2014	38	28	37
Nov 2014	70	34	27
Dec 2014	63	21	32
Total 2014	576	304	684
Jan 2015	22	27	36
Feb 2015	40	26	45
Mar 2015	79	18	28
Apr 2015	63	28	39
May 2015	40	11	26
Jun 2015	66	24	25
Jul 2015	29	10	25
Aug 2015	20	11	17
Sep 2015	223	14	22
Oct 2015	78	19	32
Nov 2015	61	26	24
Dec 2015	46	17	13
Total 2015	767	231	332
Jan 2016	50	21	37
Feb 2016	41	27	21
Mar 2016	71	41	46
Apr 2016	35	16	13
May 2016	45	19	26
Jun 2016	28	8	10
Jul 2016	18	20	16
Aug 2016	24	16	25
Sep 2016	40	15	15
Oct 2016	40	63	14
Nov 2016	69	37	37
Dec 2016	42	33	16
Total 2016	503	316	276
Jan 2017	29	17	10
Feb 2017	22	24	20
Mar 2017	26	29	18
Apr 2017	33	17	59
May 2017	31	76	31
Jun 2017	14	13	9
Jul 2017	21	14	4
Aug 2017	9	16	8
Sep 2017	17	19	7
Oct 2017	52	32	28
Nov 2017	43	45	22
Dec 2017	33	23	14
Total 2017	330	325	230
Jan 2018	17	27	6
Feb 2018	7	33	12
Mar 2018	5	8	4
Apr 2018	9	17	3
May 2018	4	19	5
Jun 2018	4	24	3
Jul 2018	19	18	18
Aug 2018	16	17	13
Sep 2018	24	35	15
Oct 2018	38	47	37
Nov 2018	50	32	23
Dec 2018	24	51	21
Total 2018	217	328	160
Jan 2019	22	42	21
Feb 2019	26	25	35
Mar 2019	29	56	30
Apr 2019	26	41	18
May 2019	39	39	18
Jun 2019	11	23	11
Jul 2019	12	18	19
Aug 2019	14	20	24
Sep 2019	8	18	12
Oct 2019	35	50	26
Nov 2019	26	26	26
Dec 2019	14	36	10
Total 2019	262	394	250
Jan 2020	16	16	11
Feb 2020	35	23	26
Mar 2020	19	19	8
Apr 2020	28	16	27
May 2020	16	13	10
Jun 2020	13	6	9
Jul 2020	11	15	4
Aug 2020	9	17	3
Sep 2020	25	39	39
Oct 2020	23	32	16
Nov 2020	32	41	34
Dec 2020	39	52	35
Total 2020	266	289	222
Jan 2021	21	45	29
Total 2021	21	45	29
Total	8240	9588	8976