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Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

Linda A. Kotilinek, Brian Bacskai, Marcus Westerman, Takeshi Kawarabayashi, Linda Younkin, Bradley T. Hyman, Steven Younkin and Karen H. Ashe
Journal of Neuroscience 1 August 2002, 22 (15) 6331-6335; https://doi.org/10.1523/JNEUROSCI.22-15-06331.2002
Linda A. Kotilinek
1Departments of Neurology and Neuroscience, University of Minnesota, Minneapolis 55455,
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Brian Bacskai
2Department of Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and
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Marcus Westerman
1Departments of Neurology and Neuroscience, University of Minnesota, Minneapolis 55455,
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Takeshi Kawarabayashi
3Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224
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Linda Younkin
3Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224
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Bradley T. Hyman
2Department of Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and
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Steven Younkin
3Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224
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Karen H. Ashe
1Departments of Neurology and Neuroscience, University of Minnesota, Minneapolis 55455,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-15-06331.2002
PubMed 
12151510
Published By 
Society for Neuroscience
History 
  • Received April 1, 2002
  • Revision received May 10, 2002
  • Accepted May 20, 2002
  • First published August 1, 2002.
  • Version of record published August 1, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Linda A. Kotilinek1,
  2. Brian Bacskai2,
  3. Marcus Westerman1,
  4. Takeshi Kawarabayashi3,
  5. Linda Younkin3,
  6. Bradley T. Hyman2,
  7. Steven Younkin3, and
  8. Karen H. Ashe1
  1. 1Departments of Neurology and Neuroscience, University of Minnesota, Minneapolis 55455,
  2. 2Department of Neurology, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, and
  3. 3Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224
View Full Text

Author contributions

Disclosures

    • Received April 1, 2002.
    • Revision received May 10, 2002.
    • Accepted May 20, 2002.
  • This work was supported by National Institutes of Health Grants AG15453 (K.H.A., B.T.H., S.Y.), NS33249 (K.H.A.), MH65465 (K.H.A.), and AG08687 (B.T.H.); by a Pioneer Award from the Alzheimer's Association (B.T.H.); and by The Walter Family Foundation (B.T.H.). We gratefully acknowledge Stefanie Schrump, Deirdre Cooper-Blacketer, Jennifer Perry, Aaron Guimaraes, Jennifer Lang, Jennifer Paulson, and Nardina Nash for their expertise and dedication testing mice in the water maze. We thank Megan McLellan and Steve Kajdasz for technical assistance with immunohistological procedures and Eugene Gnida for technical help performing ELISAs.

  • Correspondence should be addressed to Karen H. Ashe, Department of Neurology, Mayo Mail Code 295, 420 Delaware Street Southeast, Minneapolis, MN 55455. E-mail: hsiao005{at}umn.edu.

  • T. Kawarabayashi's present address: Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700-8558 Japan.

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The Journal of Neuroscience: 22 (15)
Journal of Neuroscience
Vol. 22, Issue 15
1 Aug 2002
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Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease
Linda A. Kotilinek, Brian Bacskai, Marcus Westerman, Takeshi Kawarabayashi, Linda Younkin, Bradley T. Hyman, Steven Younkin, Karen H. Ashe
Journal of Neuroscience 1 August 2002, 22 (15) 6331-6335; DOI: 10.1523/JNEUROSCI.22-15-06331.2002

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Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease
Linda A. Kotilinek, Brian Bacskai, Marcus Westerman, Takeshi Kawarabayashi, Linda Younkin, Bradley T. Hyman, Steven Younkin, Karen H. Ashe
Journal of Neuroscience 1 August 2002, 22 (15) 6331-6335; DOI: 10.1523/JNEUROSCI.22-15-06331.2002
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Keywords

  • Alzheimer's disease
  • transgenic
  • behavior
  • Aβ
  • monoclonal antibodies
  • memory

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