Heat-Evoked Activation of the Ion Channel, TRPV4

Ali Deniz Güler; Hyosang Lee; Tohko Iida; Isao Shimizu; Makoto Tominaga; Michael Caterina

doi:10.1523/JNEUROSCI.22-15-06408.2002

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.22-15-06408.2002

PubMed

12151520

Published By

Society for Neuroscience

History

Received February 15, 2002
Revision received May 20, 2002
Accepted May 20, 2002
Published in print August 1, 2002.

Author Information

Ali Deniz Güler1,
Hyosang Lee1,
Tohko Iida2,
Isao Shimizu1,3,
Makoto Tominaga2, and
Michael Caterina1

¹Departments of Biological Chemistry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205,
²Department of Physiology, Mie University School of Medicine, Tsu/Mie 514-8507, Japan, and
³Dainippon Pharmaceutical Company, Limited, Suita/Osaka 564-0053, Japan

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Author contributions

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Disclosures

Received February 15, 2002.
Revision received May 20, 2002.
Accepted May 20, 2002.

This work was supported by American Cancer Society Grant RGS-01-063-01-CSM; by awards from the W. M. Keck Foundation, Searle Scholars Program, and Arnold and Mabel Beckman Foundation and a gift from Dainippon Pharmaceuticals to M.J.C.; and by grants from the Ministry of Education, Culture, Sports and Technology, Japan to M.T. We thank J. Wang and R. Evans for technical assistance and P. Coulombe, D. Johns, M. Nealen, and C. Montell for valuable suggestions.
Correspondence should be addressed to M. J. Caterina, Departments of Biological Chemistry and Neuroscience, 725 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205. E-mail:caterina{at}jhmi.edu.

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	Abstract	Full	Pdf
Jul 2002	18	8	33
Aug 2002	336	279	575
Sep 2002	18	136	141
Oct 2002	12	123	116
Nov 2002	4	82	90
Dec 2002	3	85	65
Total 2002	391	713	1020
Jan 2003	5	90	47
Feb 2003	6	88	70
Mar 2003	3	108	83
Apr 2003	6	110	70
May 2003	6	112	91
Jun 2003	5	76	59
Jul 2003	6	72	63
Aug 2003	16	64	56
Sep 2003	25	84	70
Oct 2003	37	88	58
Nov 2003	54	103	77
Dec 2003	40	63	52
Total 2003	209	1058	796
Jan 2004	42	82	65
Feb 2004	34	79	63
Mar 2004	40	86	57
Apr 2004	27	91	61
May 2004	53	99	44
Jun 2004	28	74	67
Jul 2004	50	120	36
Aug 2004	66	100	28
Sep 2004	57	102	37
Oct 2004	29	104	58
Nov 2004	25	101	66
Dec 2004	32	68	37
Total 2004	483	1106	619
Jan 2005	26	80	57
Feb 2005	23	65	50
Mar 2005	37	79	68
Apr 2005	15	81	54
May 2005	30	82	42
Jun 2005	16	56	42
Jul 2005	13	37	26
Aug 2005	10	51	44
Sep 2005	12	40	39
Oct 2005	21	70	53
Nov 2005	23	65	30
Dec 2005	18	39	35
Total 2005	244	745	540
Jan 2006	18	61	41
Feb 2006	12	61	37
Mar 2006	8	66	46
Apr 2006	14	67	35
May 2006	21	67	41
Jun 2006	21	49	41
Jul 2006	9	32	22
Aug 2006	15	53	29
Sep 2006	19	34	25
Oct 2006	23	40	34
Nov 2006	12	55	24
Dec 2006	14	29	24
Total 2006	186	614	399
Jan 2007	19	58	42
Feb 2007	24	49	39
Mar 2007	20	55	45
Apr 2007	14	44	34
May 2007	20	76	57
Jun 2007	8	36	33
Jul 2007	12	30	24
Aug 2007	17	47	27
Sep 2007	17	39	22
Oct 2007	29	44	43
Nov 2007	12	56	41
Dec 2007	17	26	28
Total 2007	209	560	435
Jan 2008	11	37	34
Feb 2008	16	31	33
Mar 2008	27	38	29
Apr 2008	30	37	26
May 2008	38	45	44
Jun 2008	19	44	39
Jul 2008	13	51	36
Aug 2008	22	44	18
Sep 2008	32	55	32
Oct 2008	41	45	43
Nov 2008	24	29	28
Dec 2008	24	33	19
Total 2008	297	489	381
Jan 2009	21	44	40
Feb 2009	28	45	45
Mar 2009	22	40	41
Apr 2009	11	30	30
May 2009	33	42	32
Jun 2009	16	47	46
Jul 2009	26	37	39
Aug 2009	14	38	41
Sep 2009	11	35	37
Oct 2009	10	65	44
Nov 2009	18	49	48
Dec 2009	16	34	23
Total 2009	226	506	466
Jan 2010	31	26	29
Feb 2010	30	46	30
Mar 2010	30	60	63
Apr 2010	19	38	30
May 2010	29	54	41
Jun 2010	16	34	36
Jul 2010	17	34	26
Aug 2010	25	31	28
Sep 2010	30	33	28
Oct 2010	20	57	43
Nov 2010	28	54	50
Dec 2010	24	38	28
Total 2010	299	505	432
Jan 2011	16	61	40
Feb 2011	27	36	35
Mar 2011	44	41	23
Apr 2011	56	58	47
May 2011	38	47	50
Jun 2011	31	41	47
Jul 2011	28	38	32
Aug 2011	37	30	41
Sep 2011	22	39	47
Oct 2011	39	32	38
Nov 2011	37	33	45
Dec 2011	33	33	41
Total 2011	408	489	486
Jan 2012	32	35	33
Feb 2012	35	40	57
Mar 2012	44	41	45
Apr 2012	47	40	47
May 2012	28	48	43
Jun 2012	33	32	30
Jul 2012	26	44	39
Aug 2012	28	29	31
Sep 2012	23	25	21
Oct 2012	45	21	37
Nov 2012	52	24	58
Dec 2012	48	29	49
Total 2012	441	408	490
Jan 2013	30	22	32
Feb 2013	42	23	35
Mar 2013	42	42	40
Apr 2013	38	23	23
May 2013	40	31	26
Jun 2013	30	19	31
Jul 2013	23	27	43
Aug 2013	29	20	30
Sep 2013	24	19	22
Oct 2013	38	28	41
Nov 2013	37	35	48
Dec 2013	34	16	24
Total 2013	407	305	395
Jan 2014	25	23	51
Feb 2014	41	30	53
Mar 2014	33	18	36
Apr 2014	38	21	46
May 2014	153	31	33
Jun 2014	44	29	33
Jul 2014	35	32	43
Aug 2014	25	27	62
Sep 2014	37	38	57
Oct 2014	25	38	38
Nov 2014	45	31	33
Dec 2014	18	29	26
Total 2014	519	347	511
Jan 2015	47	32	50
Feb 2015	35	27	49
Mar 2015	50	40	37
Apr 2015	27	46	36
May 2015	39	42	42
Jun 2015	21	32	37
Jul 2015	18	21	28
Aug 2015	28	17	35
Sep 2015	33	51	36
Oct 2015	19	37	21
Nov 2015	32	41	41
Dec 2015	36	32	34
Total 2015	385	418	446
Jan 2016	56	31	39
Feb 2016	65	32	30
Mar 2016	36	45	49
Apr 2016	46	52	49
May 2016	33	55	122
Jun 2016	48	37	39
Jul 2016	24	37	40
Aug 2016	37	35	45
Sep 2016	67	31	38
Oct 2016	39	39	45
Nov 2016	23	40	52
Dec 2016	17	113	72
Total 2016	491	547	620
Jan 2017	12	81	44
Feb 2017	14	83	72
Mar 2017	16	64	58
Apr 2017	57	81	52
May 2017	28	83	27
Jun 2017	15	43	39
Jul 2017	14	56	37
Aug 2017	12	204	23
Sep 2017	16	66	20
Oct 2017	16	31	17
Nov 2017	19	43	21
Dec 2017	15	41	16
Total 2017	234	876	426
Jan 2018	9	35	36
Feb 2018	2	42	34
Mar 2018	9	47	35
Apr 2018	2	54	27
May 2018	2	83	35
Jun 2018	2	67	11
Jul 2018	17	59	34
Aug 2018	20	31	26
Sep 2018	17	44	28
Oct 2018	22	54	49
Nov 2018	15	46	20
Dec 2018	19	23	18
Total 2018	136	585	353
Jan 2019	19	42	33
Feb 2019	22	53	39
Mar 2019	17	41	43
Apr 2019	14	34	28
May 2019	19	42	31
Jun 2019	17	43	40
Jul 2019	24	59	57
Aug 2019	21	46	37
Sep 2019	20	80	36
Oct 2019	18	83	40
Nov 2019	6	14	6
Total 2019	197	537	390
Total	5762	10808	9205