Heat-Evoked Activation of the Ion Channel, TRPV4

This work was supported by American Cancer Society Grant RGS-01-063-01-CSM; by awards from the W. M. Keck Foundation, Searle Scholars Program, and Arnold and Mabel Beckman Foundation and a gift from Dainippon Pharmaceuticals to M.J.C.; and by grants from the Ministry of Education, Culture, Sports and Technology, Japan to M.T. We thank J. Wang and R. Evans for technical assistance and P. Coulombe, D. Johns, M. Nealen, and C. Montell for valuable suggestions.

Correspondence should be addressed to M. J. Caterina, Departments of Biological Chemistry and Neuroscience, 725 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205. E-mail:caterina{at}jhmi.edu.