In Vitro Neurotoxicity of Methylisothiazolinone, a Commonly Used Industrial and Household Biocide, Proceeds via a Zinc and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase-Dependent Pathway

This work was supported in part by National Institutes of Health Grant NS29365 and by an American Heart Association grant-in-aid. We thank Drs. Paul Rosenberg, Ian Reynolds, and Don DeFranco and Daniel Leszkiewicz and Kirk Dineley for helpful comments and suggestions, Dr. Frank Barone for SB239063, Dr. Carl Lagenaur for the astrocyte cultures, and Karen Hartnett for assistance with some of the experiments.

Correspondence should be addressed to Dr. Elias Aizenman, Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 Biomedical Science Tower, Pittsburgh, PA 15261. E-mail:redox{at}pitt.edu.