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ARTICLE, Cellular/Molecular

Structural Evidence that Propofol Stabilizes Different GABAA Receptor States at Potentiating and Activating Concentrations

Daniel B. Williams and Myles H. Akabas
Journal of Neuroscience 1 September 2002, 22 (17) 7417-7424; DOI: https://doi.org/10.1523/JNEUROSCI.22-17-07417.2002
Daniel B. Williams
1Departments of Physiology and Biophysics and
3Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, New York, New York 10032
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Myles H. Akabas
1Departments of Physiology and Biophysics and
2Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-17-07417.2002
PubMed 
12196563
Published By 
Society for Neuroscience
History 
  • Received March 20, 2002
  • Revision received April 23, 2002
  • Accepted April 25, 2002
  • First published September 1, 2002.
  • Version of record published September 1, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Daniel B. Williams1,3 and
  2. Myles H. Akabas1,2
  1. 1Departments of Physiology and Biophysics and
  2. 2Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, and
  3. 3Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, New York, New York 10032
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Author contributions

Disclosures

    • Received March 20, 2002.
    • Revision received April 23, 2002.
    • Accepted April 25, 2002.
  • This work was supported in part by National Institutes of Health Grants GM61925, NS30808, and GM63266. We thank Drs. Neil Harrison, Andrew Jenkins, and Jeffrey Horenstein for helpful discussions, Eric Goren for preparation of oocytes, and Drs. Moez Bali, Amal Bera, and Jeffrey Horenstein for comments on this manuscript.

  • Correspondence should be addressed to Dr. Myles Akabas, Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. E-mail: makabas{at}aecom.yu.edu.

  • D. B. Williams' present address: Laboratory for Molecular Neuropharmacology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5C103, 10 Center Drive, Bethesda, MD 20892.

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The Journal of Neuroscience: 22 (17)
Journal of Neuroscience
Vol. 22, Issue 17
1 Sep 2002
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Structural Evidence that Propofol Stabilizes Different GABAA Receptor States at Potentiating and Activating Concentrations
Daniel B. Williams, Myles H. Akabas
Journal of Neuroscience 1 September 2002, 22 (17) 7417-7424; DOI: 10.1523/JNEUROSCI.22-17-07417.2002

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Structural Evidence that Propofol Stabilizes Different GABAA Receptor States at Potentiating and Activating Concentrations
Daniel B. Williams, Myles H. Akabas
Journal of Neuroscience 1 September 2002, 22 (17) 7417-7424; DOI: 10.1523/JNEUROSCI.22-17-07417.2002
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Keywords

  • acetylcholine
  • glycine
  • anesthesia
  • benzodiazepine
  • isoflurane
  • ethanol

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