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ARTICLE, Behavioral/Systems

Prefrontal Cortex Long-Term Potentiation, But Not Long-Term Depression, Is Associated with the Maintenance of Extinction of Learned Fear in Mice

Cyril Herry and René Garcia
Journal of Neuroscience 15 January 2002, 22 (2) 577-583; https://doi.org/10.1523/JNEUROSCI.22-02-00577.2002
Cyril Herry
1Laboratoire de Neurosciences Cognitives, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5106, Université de Bordeaux I, 33405 Talence, France, and
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René Garcia
2Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Nice-Sophia Antipolis, 06108 Nice, France
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    Fig. 1.

    A, Diagrams of coronal sections of the mouse brain showing electrode placements (dotted areas) in the MD (left) and the mPFC (right). CC, Corpus callosum;HPC, dorsal hippocampus. B, Example of changes in field potential amplitude in a mouse from the LFS group. These representative responses were recorded during the establishment of the baseline (left) and the third sessions of extinction (right). Changes in prefrontal excitability corresponded to changes in the amplitude of the N1–P2 complex (the amplitude A, between the two dotted lines, represents the reference amplitude of the N1–N2 complex).

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    Fig. 2.

    A, Mean percentage of changes in N1–P2 amplitude (±SEM) during the 3 d of baseline recording (D1–D8), before the first session (D9a), during sessions (D9b–D11), and 24 hr after the last session (D12) of extinction in conditioned mice that received (LFS group) or did not receive (NLFS group) thalamic LFS and nonconditioned mice (control group). Fear conditioning (FC) took place after the last baseline recording (D8). B, Mean percentage of freezing behavior (±SEM) in the three groups during the 120 sec period preceding the first CS-alone presentation (D9a) and sessions of CS-alone presentations (D9b–D11).

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    Fig. 3.

    A, Example of change in MD–mPFC-evoked response after thalamic HFS. These representative responses were recorded during the establishment of the baseline and 32 min after thalamic HFS (the amplitude between the two dotted lines represents the reference amplitude of the N1–P2 complex). B, Mean percentage changes in N1–P2 amplitude (±SEM) during different recording sessions (before and after thalamic HFS).

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    Fig. 4.

    A, Mean percentage of changes in N1–P2 amplitude (±SEM) during the 3 d of baseline recording (D1–D8), before the first session (D9a) and during sessions (D9b–D9e) of extinction, before (D16a) and during (D16b) the follow-up test in conditioned mice that received HFS before extinction (HFS group) and their controls that did not receive HFS (NHFS1 and NHFS2 groups). Fear conditioning (FC) took place after the last baseline recording (D8). B, Mean percentage of freezing behavior (±SEM) in the three groups during the 120 sec period preceding the first CS-alone presentation (D9a), during CS-alone presentations (D9b–D9e), and during the 1 week follow-up test of CS-alone presentations (D16b). The dotted line represents mean level of freezing displayed by nonconditioned mice (experiment 1).

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The Journal of Neuroscience: 22 (2)
Journal of Neuroscience
Vol. 22, Issue 2
15 Jan 2002
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Prefrontal Cortex Long-Term Potentiation, But Not Long-Term Depression, Is Associated with the Maintenance of Extinction of Learned Fear in Mice
Cyril Herry, René Garcia
Journal of Neuroscience 15 January 2002, 22 (2) 577-583; DOI: 10.1523/JNEUROSCI.22-02-00577.2002

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Prefrontal Cortex Long-Term Potentiation, But Not Long-Term Depression, Is Associated with the Maintenance of Extinction of Learned Fear in Mice
Cyril Herry, René Garcia
Journal of Neuroscience 15 January 2002, 22 (2) 577-583; DOI: 10.1523/JNEUROSCI.22-02-00577.2002
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Keywords

  • fear conditioning
  • extinction
  • long-term depression
  • long-term potentiation
  • medial prefrontal cortex
  • mouse

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