Article Figures & Data
Figures
- Fig. 1.
A, Diagrams of coronal sections of the mouse brain showing electrode placements (dotted areas) in the MD (left) and the mPFC (right). CC, Corpus callosum;HPC, dorsal hippocampus. B, Example of changes in field potential amplitude in a mouse from the LFS group. These representative responses were recorded during the establishment of the baseline (left) and the third sessions of extinction (right). Changes in prefrontal excitability corresponded to changes in the amplitude of the N1–P2 complex (the amplitude A, between the two dotted lines, represents the reference amplitude of the N1–N2 complex).
- Fig. 2.
A, Mean percentage of changes in N1–P2 amplitude (±SEM) during the 3 d of baseline recording (D1–D8), before the first session (D9a), during sessions (D9b–D11), and 24 hr after the last session (D12) of extinction in conditioned mice that received (LFS group) or did not receive (NLFS group) thalamic LFS and nonconditioned mice (control group). Fear conditioning (FC) took place after the last baseline recording (D8). B, Mean percentage of freezing behavior (±SEM) in the three groups during the 120 sec period preceding the first CS-alone presentation (D9a) and sessions of CS-alone presentations (D9b–D11).
- Fig. 3.
A, Example of change in MD–mPFC-evoked response after thalamic HFS. These representative responses were recorded during the establishment of the baseline and 32 min after thalamic HFS (the amplitude between the two dotted lines represents the reference amplitude of the N1–P2 complex). B, Mean percentage changes in N1–P2 amplitude (±SEM) during different recording sessions (before and after thalamic HFS).
- Fig. 4.
A, Mean percentage of changes in N1–P2 amplitude (±SEM) during the 3 d of baseline recording (D1–D8), before the first session (D9a) and during sessions (D9b–D9e) of extinction, before (D16a) and during (D16b) the follow-up test in conditioned mice that received HFS before extinction (HFS group) and their controls that did not receive HFS (NHFS1 and NHFS2 groups). Fear conditioning (FC) took place after the last baseline recording (D8). B, Mean percentage of freezing behavior (±SEM) in the three groups during the 120 sec period preceding the first CS-alone presentation (D9a), during CS-alone presentations (D9b–D9e), and during the 1 week follow-up test of CS-alone presentations (D16b). The dotted line represents mean level of freezing displayed by nonconditioned mice (experiment 1).
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