Article Figures & Data
Figures
- Fig. 1.
The SVZ–OB system. Schematic sagittal view of the adult rodent brain with the OB to the left and the cerebellum (CB) to the right. The SVZ is along the lateral wall of the lateral ventricle (LV, blue). New neurons are constantly produced throughout the SVZ. The young neurons (A cells) (Fig. 3) become aligned into long chains (red lines) (Fig. 2) that form a complex network of interconnected paths throughout the SVZ. Many of these chains in the anterior SVZ connect with the RMS, which leads young neurons into the core of the olfactory bulb. Within the olfactory bulb, cells disperse radially (dotted lines) as individual cells and complete their differentiation into granule and periglomerular interneurons.NC, Neocortex; cc, corpus callosum.
- Fig. 2.
Chain migration. Young neurons within the SVZ network and in the RMS migrate along each other to form long chains. Chains of migrating cells (red) are ensheathed by glial cells (blue) that have astrocytic characteristics, including dense bundles of GFAP-containing intermediate filaments and endings on blood vessel (below). Two chains are illustrated here. In the bottom chain only some of the astrocytes have been drawn to illustrate the tight organization of A cell into chains. The intracellular characteristics of some of the B cells (light blue) and A cells (yellow) are illustrated. An A cell in mitosis is illustrated in thebottom chain to the right.
- Fig. 3.
Organization and lineage in the SVZ.Left, Cross section of the anterior rodent brain indicating the location of the SVZ on the lateral wall of the LV. On the right is the cellular composition and organization of the SVZ. Chains of young neurons (A cells, red) are surrounded by B cells (blue) that have astrocytic characteristics and form tube-like structures. Clusters of highly proliferative C cells are associated with the chains of A cells. Ependymal (E) cells form an epithelial layer that separates the SVZ from the ventricle (LV). B cells generate transient amplifying C cells that generate the A cells (top). Bottom left, BMPs inhibit neurogenesis and favor glial differentiation (blue). Noggin secreted by ependymal cells binds BMPs and releases some B cells to become neurogenic and produce C (green) and A (red) cells.
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