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MINI-REVIEW

Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis

Gerd Kempermann
Journal of Neuroscience 1 February 2002, 22 (3) 635-638; https://doi.org/10.1523/JNEUROSCI.22-03-00635.2002
Gerd Kempermann
1Research Group VolkswagenStiftung at the Department of Experimental Neurology, Charité University Hospital, Humboldt University Berlin, 10117 Berlin, Germany, and
2Max Delbrück Center for Molecular Medicine, Berlin-Buch, 13125 Berlin, Germany
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    Fig. 1.

    A, The hippocampus presumably serves as the “gateway to memory.” New neurons are added at the bottleneck of the neuronal circuitry in response to functional stimulation. The theory presented here is that adult neurogenesis is not involved in increasing memory per se, but in a long-term adjustment of the processing unit “hippocampus” to increased functional needs.B, In contrast, a simplifying computer analogy considers new neurons in the dentate gyrus as a means of increasing working memory (“RAM” in computer terminology). There is no indication that hippocampal neurogenesis is involved in increasing storage memory (“hard disk” in computer terminology). C, A small number of new neurons can only make a big difference if they are strategically used to adapt the existing network. Here, the new neurons are marked in red.

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The Journal of Neuroscience: 22 (3)
Journal of Neuroscience
Vol. 22, Issue 3
1 Feb 2002
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Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis
Gerd Kempermann
Journal of Neuroscience 1 February 2002, 22 (3) 635-638; DOI: 10.1523/JNEUROSCI.22-03-00635.2002

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Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis
Gerd Kempermann
Journal of Neuroscience 1 February 2002, 22 (3) 635-638; DOI: 10.1523/JNEUROSCI.22-03-00635.2002
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