Consequences of the Stoichiometry of Slo1 α and Auxiliary β Subunits on Functional Properties of Large-Conductance  Ca2+-Activated K+Channels

Ying-Wei Wang; Jiu Ping Ding; Xiao-Ming Xia; Christopher J. Lingle

doi:10.1523/JNEUROSCI.22-05-01550.2002

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.22-05-01550.2002

PubMed

11880485

Published By

Society for Neuroscience

History

Received November 2, 2001
Revision received December 7, 2001
Accepted December 7, 2001
First published March 1, 2002.

Version of record published March 1, 2002.

Author Information

Ying-Wei Wang,
Jiu Ping Ding,
Xiao-Ming Xia, and
Christopher J. Lingle

¹Departments of Anesthesiology and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

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Author contributions

Disclosures

Received November 2, 2001.
Revision received December 7, 2001.
Accepted December 7, 2001.

This work was supported by National Institutes of Health Grants DK46564 and NS37671. We thank Lynn Lavack for injection and care of oocytes.
Correspondence should be addressed to Chris Lingle, Department of Anesthesiology, Washington University School of Medicine, Box 8054, St. Louis, MO 63110. E-mail: clingle{at}morpheus.wustl.edu.

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	Abstract	Full	Pdf
Mar 2002	151	175	149
Apr 2002	7	72	63
May 2002	19	52	61
Jun 2002	0	29	25
Jul 2002	2	33	28
Aug 2002	3	23	18
Sep 2002	3	14	8
Oct 2002	3	36	38
Nov 2002	4	35	19
Dec 2002	2	19	9
Total 2002	194	488	418
Jan 2003	0	17	13
Feb 2003	1	24	21
Mar 2003	1	21	17
Apr 2003	1	15	20
May 2003	1	24	18
Jun 2003	4	17	19
Jul 2003	6	26	22
Aug 2003	8	16	13
Sep 2003	6	20	9
Oct 2003	8	17	11
Nov 2003	13	41	41
Dec 2003	13	30	18
Total 2003	62	268	222
Jan 2004	18	32	14
Feb 2004	13	32	19
Mar 2004	20	34	9
Apr 2004	25	39	20
May 2004	22	33	7
Jun 2004	17	39	20
Jul 2004	14	30	12
Aug 2004	14	26	18
Sep 2004	14	27	10
Oct 2004	13	29	15
Nov 2004	8	22	16
Dec 2004	19	21	6
Total 2004	197	364	166
Jan 2005	12	19	12
Feb 2005	13	22	13
Mar 2005	14	27	13
Apr 2005	7	22	10
May 2005	6	14	9
Jun 2005	7	28	11
Jul 2005	9	19	10
Aug 2005	7	18	13
Sep 2005	13	13	22
Oct 2005	10	33	19
Nov 2005	7	26	18
Dec 2005	4	10	12
Total 2005	109	251	162
Jan 2006	4	10	6
Feb 2006	3	13	5
Mar 2006	4	13	5
Apr 2006	0	9	8
May 2006	0	6	5
Jun 2006	1	13	15
Jul 2006	0	14	4
Aug 2006	2	11	10
Sep 2006	1	9	4
Oct 2006	4	21	9
Nov 2006	4	17	13
Dec 2006	3	8	5
Total 2006	26	144	89
Jan 2007	3	8	7
Feb 2007	2	8	4
Mar 2007	4	8	8
Apr 2007	2	19	12
May 2007	2	26	10
Jun 2007	0	5	5
Jul 2007	1	7	7
Aug 2007	2	8	6
Sep 2007	4	5	6
Oct 2007	1	11	6
Nov 2007	1	10	6
Dec 2007	1	10	5
Total 2007	23	125	82
Jan 2008	0	7	5
Feb 2008	3	13	8
Mar 2008	4	14	7
Apr 2008	6	9	5
May 2008	11	11	7
Jun 2008	7	14	8
Jul 2008	1	4	3
Aug 2008	4	10	8
Sep 2008	7	3	2
Oct 2008	14	4	3
Nov 2008	9	8	2
Dec 2008	7	4	5
Total 2008	73	101	63
Jan 2009	3	5	4
Feb 2009	4	8	3
Mar 2009	13	17	13
Apr 2009	4	5	3
May 2009	4	5	3
Jun 2009	7	5	6
Jul 2009	5	13	7
Aug 2009	1	1	2
Sep 2009	0	9	5
Oct 2009	2	2	6
Nov 2009	5	3	4
Dec 2009	3	4	3
Total 2009	51	77	59
Jan 2010	4	3	2
Feb 2010	2	7	10
Mar 2010	2	5	4
Apr 2010	2	6	8
May 2010	7	6	10
Jun 2010	2	3	5
Jul 2010	1	13	3
Aug 2010	1	7	2
Sep 2010	6	7	10
Oct 2010	3	6	4
Nov 2010	5	6	5
Dec 2010	5	6	3
Total 2010	40	75	66
Jan 2011	4	2	2
Feb 2011	8	7	10
Mar 2011	6	11	6
Apr 2011	7	18	14
May 2011	3	9	6
Jun 2011	0	11	8
Jul 2011	12	6	8
Aug 2011	3	7	10
Sep 2011	9	1	3
Oct 2011	12	8	8
Nov 2011	12	11	7
Dec 2011	6	8	14
Total 2011	82	99	96
Jan 2012	5	11	10
Feb 2012	7	5	11
Mar 2012	11	5	10
Apr 2012	5	2	5
May 2012	12	5	5
Jun 2012	9	8	11
Jul 2012	8	6	6
Aug 2012	8	7	6
Sep 2012	19	8	5
Oct 2012	18	17	11
Nov 2012	17	1	5
Dec 2012	23	5	8
Total 2012	142	80	93
Jan 2013	13	11	13
Feb 2013	10	15	12
Mar 2013	10	10	14
Apr 2013	9	12	14
May 2013	5	3	6
Jun 2013	3	4	7
Jul 2013	10	9	5
Aug 2013	6	7	6
Sep 2013	1	3	4
Oct 2013	8	4	8
Nov 2013	2	6	2
Dec 2013	9	3	5
Total 2013	86	87	96
Jan 2014	1	3	3
Feb 2014	5	4	8
Mar 2014	13	6	5
Apr 2014	3	13	7
May 2014	8	3	3
Jun 2014	3	5	2
Jul 2014	11	11	10
Aug 2014	6	6	4
Sep 2014	10	19	5
Oct 2014	9	12	7
Nov 2014	8	6	5
Dec 2014	6	3	3
Total 2014	83	91	62
Jan 2015	10	16	7
Feb 2015	11	10	6
Mar 2015	4	15	10
Apr 2015	2	4	1
May 2015	3	1	1
Jun 2015	3	2	7
Jul 2015	1	7	7
Aug 2015	9	2	1
Sep 2015	10	6	4
Oct 2015	5	8	9
Nov 2015	5	7	7
Dec 2015	5	2	4
Total 2015	68	80	64
Jan 2016	3	7	5
Feb 2016	8	8	10
Mar 2016	6	12	10
Apr 2016	5	8	4
May 2016	9	9	6
Jun 2016	6	5	5
Jul 2016	11	5	4
Aug 2016	7	9	5
Sep 2016	32	12	6
Oct 2016	3	9	5
Nov 2016	2	22	6
Dec 2016	1	17	6
Total 2016	93	123	72
Jan 2017	1	8	6
Feb 2017	1	10	7
Mar 2017	2	104	7
Apr 2017	1	61	10
May 2017	0	24	4
Jun 2017	0	10	6
Jul 2017	2	15	3
Aug 2017	0	9	3
Sep 2017	0	8	0
Oct 2017	0	15	1
Nov 2017	1	10	3
Dec 2017	2	5	3
Total 2017	10	279	53
Jan 2018	0	15	3
Feb 2018	3	15	6
Mar 2018	0	14	3
Apr 2018	2	17	3
May 2018	1	16	4
Jun 2018	7	19	4
Jul 2018	4	13	5
Aug 2018	3	12	2
Sep 2018	3	13	3
Oct 2018	7	12	6
Nov 2018	3	11	4
Dec 2018	0	9	1
Total 2018	33	166	44
Jan 2019	4	20	6
Feb 2019	2	12	4
Mar 2019	8	17	10
Apr 2019	12	15	8
May 2019	8	20	8
Jun 2019	1	8	3
Jul 2019	3	11	8
Aug 2019	1	62	7
Sep 2019	2	101	3
Oct 2019	4	205	6
Nov 2019	0	16	6
Dec 2019	1	11	2
Total 2019	46	498	71
Jan 2020	0	13	4
Feb 2020	1	13	3
Mar 2020	4	8	5
Apr 2020	2	6	3
May 2020	4	27	5
Jun 2020	3	12	3
Jul 2020	0	12	1
Aug 2020	0	12	2
Sep 2020	7	16	3
Oct 2020	1	20	6
Nov 2020	3	43	10
Dec 2020	4	16	4
Total 2020	29	198	49
Jan 2021	2	116	7
Feb 2021	0	10	1
Total 2021	2	126	8
Total	1449	3720	2035