Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cδ Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

This work was supported by the National Institute of Environmental Health Sciences Grant RO1-ES10586. We acknowledge Dr. Palur Gunasekar (Operational Toxicology, Air Force Research Laboratories, Dayton, OH) for his initial assistance in some experiments. We thank Dr. Michael L. Kirby, Dr. Arthi Kanthasamy, and Mr. Siddharth Ranade in the preparation of this manuscript and Dr. Donghui Cheng for help with flow cytometry.

Correspondence should be addressed to Dr. A. G. Kanthasamy, Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, 2062 Veterinary Medicine Building, Iowa Sate University, Ames, IA 50011. E-mail: akanthas{at}iastate.edu.

J. Wagner's present address: Department of Chemistry, California State University, Fresno, CA.