Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease

Inna I. Kruman; T. S. Kumaravel; Althaf Lohani; Ward A. Pedersen; Roy G. Cutler; Yuri Kruman; Norman Haughey; Jaewon Lee; Michele Evans; Mark P. Mattson

doi:10.1523/JNEUROSCI.22-05-01752.2002

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.22-05-01752.2002

PubMed

11880504

Published By

Society for Neuroscience

History

Received August 8, 2001
Revision received December 18, 2001
Accepted December 18, 2001
First published March 1, 2002.

Version of record published March 1, 2002.

Author Information

Inna I. Kruman1,
T. S. Kumaravel2,
Althaf Lohani2,
Ward A. Pedersen1,
Roy G. Cutler1,
Yuri Kruman1,
Norman Haughey1,
Jaewon Lee1,
Michele Evans2, and
Mark P. Mattson1,3

¹Laboratories of Neurosciences and
²Cellular and Molecular Biology, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, and
³Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Author contributions

Disclosures

Received August 8, 2001.
Revision received December 18, 2001.
Accepted December 18, 2001.

We thank D. Borchelt for providing initial breeding pairs of mice, J. Lee for technical assistance, and D. Ingram for valuable discussions.
Correspondence should be addressed to Mark P. Mattson, Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224. E-mail:mattsonm{at}grc.nia.nih.gov.

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	Abstract	Full	Pdf
Mar 2002	647	904	724
Apr 2002	110	375	242
May 2002	50	206	141
Jun 2002	24	123	75
Jul 2002	28	87	51
Aug 2002	28	123	79
Sep 2002	28	98	84
Oct 2002	28	80	54
Nov 2002	21	86	96
Dec 2002	27	58	26
Total 2002	991	2140	1572
Jan 2003	13	62	37
Feb 2003	24	79	44
Mar 2003	23	102	93
Apr 2003	16	71	74
May 2003	16	82	84
Jun 2003	10	65	56
Jul 2003	27	188	82
Aug 2003	25	67	52
Sep 2003	28	81	61
Oct 2003	43	76	85
Nov 2003	52	89	95
Dec 2003	41	73	69
Total 2003	318	1035	832
Jan 2004	40	88	77
Feb 2004	30	73	59
Mar 2004	57	87	67
Apr 2004	28	67	58
May 2004	62	117	53
Jun 2004	60	173	63
Jul 2004	51	153	71
Aug 2004	74	126	47
Sep 2004	71	136	86
Oct 2004	44	250	85
Nov 2004	39	118	81
Dec 2004	39	120	44
Total 2004	595	1508	791
Jan 2005	52	126	56
Feb 2005	33	127	80
Mar 2005	68	110	73
Apr 2005	38	74	36
May 2005	38	79	62
Jun 2005	52	107	55
Jul 2005	32	131	54
Aug 2005	35	116	52
Sep 2005	37	102	66
Oct 2005	37	134	81
Nov 2005	32	109	53
Dec 2005	36	110	52
Total 2005	490	1325	720
Jan 2006	35	124	64
Feb 2006	50	136	53
Mar 2006	22	139	45
Apr 2006	38	100	44
May 2006	45	64	43
Jun 2006	39	44	35
Jul 2006	42	59	30
Aug 2006	46	64	33
Sep 2006	67	61	44
Oct 2006	67	89	64
Nov 2006	67	94	47
Dec 2006	46	48	35
Total 2006	564	1022	537
Jan 2007	67	77	43
Feb 2007	78	60	39
Mar 2007	87	98	68
Apr 2007	56	53	53
May 2007	43	54	46
Jun 2007	30	33	22
Jul 2007	30	55	36
Aug 2007	43	77	53
Sep 2007	46	82	31
Oct 2007	50	94	46
Nov 2007	44	89	45
Dec 2007	48	54	38
Total 2007	622	826	520
Jan 2008	44	108	60
Feb 2008	47	89	52
Mar 2008	56	90	52
Apr 2008	55	108	65
May 2008	59	77	43
Jun 2008	60	81	45
Jul 2008	53	76	54
Aug 2008	37	58	21
Sep 2008	71	60	36
Oct 2008	71	87	58
Nov 2008	79	74	32
Dec 2008	49	78	35
Total 2008	681	986	553
Jan 2009	70	50	34
Feb 2009	79	57	41
Mar 2009	95	89	51
Apr 2009	53	58	38
May 2009	68	67	50
Jun 2009	59	47	31
Jul 2009	56	56	37
Aug 2009	51	52	30
Sep 2009	48	66	54
Oct 2009	56	73	56
Nov 2009	62	119	51
Dec 2009	54	55	36
Total 2009	751	789	509
Jan 2010	45	72	57
Feb 2010	64	55	33
Mar 2010	71	44	54
Apr 2010	64	72	48
May 2010	75	46	43
Jun 2010	44	46	40
Jul 2010	45	49	30
Aug 2010	42	53	33
Sep 2010	48	115	33
Oct 2010	76	137	62
Nov 2010	73	78	45
Dec 2010	69	64	32
Total 2010	716	831	510
Jan 2011	49	53	28
Feb 2011	65	60	33
Mar 2011	84	57	41
Apr 2011	64	53	31
May 2011	64	65	50
Jun 2011	50	55	67
Jul 2011	41	70	63
Aug 2011	36	46	56
Sep 2011	36	38	34
Oct 2011	93	72	60
Nov 2011	62	144	62
Dec 2011	44	178	41
Total 2011	688	891	566
Jan 2012	36	91	44
Feb 2012	55	75	48
Mar 2012	66	124	58
Apr 2012	67	64	40
May 2012	64	134	47
Jun 2012	55	169	56
Jul 2012	95	124	44
Aug 2012	54	188	40
Sep 2012	49	267	36
Oct 2012	83	68	78
Nov 2012	99	61	71
Dec 2012	84	40	52
Total 2012	807	1405	614
Jan 2013	84	48	84
Feb 2013	101	29	84
Mar 2013	87	64	69
Apr 2013	96	50	101
May 2013	81	36	100
Jun 2013	60	29	70
Jul 2013	44	27	100
Aug 2013	78	31	50
Sep 2013	76	26	46
Oct 2013	71	49	56
Nov 2013	90	71	83
Dec 2013	76	78	94
Total 2013	944	538	937
Jan 2014	123	48	101
Feb 2014	80	31	122
Mar 2014	97	35	70
Apr 2014	92	56	94
May 2014	103	47	76
Jun 2014	60	34	41
Jul 2014	84	38	58
Aug 2014	57	55	60
Sep 2014	74	72	76
Oct 2014	73	80	76
Nov 2014	75	62	95
Dec 2014	66	67	107
Total 2014	984	625	976
Jan 2015	61	52	63
Feb 2015	85	95	39
Mar 2015	82	128	28
Apr 2015	66	28	68
May 2015	35	13	63
Jun 2015	46	27	46
Jul 2015	44	47	45
Aug 2015	72	87	52
Sep 2015	56	36	47
Oct 2015	91	56	84
Nov 2015	65	20	39
Dec 2015	39	19	32
Total 2015	742	608	606
Jan 2016	81	33	41
Feb 2016	67	57	69
Mar 2016	56	27	71
Apr 2016	66	42	51
May 2016	56	24	39
Jun 2016	69	33	35
Jul 2016	60	27	26
Aug 2016	52	19	33
Sep 2016	78	22	41
Oct 2016	60	47	55
Nov 2016	70	36	60
Dec 2016	42	38	21
Total 2016	757	405	542
Jan 2017	37	51	43
Feb 2017	57	71	53
Mar 2017	52	74	46
Apr 2017	51	31	28
May 2017	36	79	24
Jun 2017	20	32	17
Jul 2017	40	54	62
Aug 2017	30	39	27
Sep 2017	30	33	26
Oct 2017	43	40	16
Nov 2017	47	47	23
Dec 2017	32	41	25
Total 2017	475	592	390
Jan 2018	42	57	35
Feb 2018	36	36	18
Mar 2018	41	54	21
Apr 2018	34	46	26
May 2018	22	64	24
Jun 2018	21	52	24
Jul 2018	53	49	37
Aug 2018	23	27	16
Sep 2018	31	43	27
Oct 2018	35	44	53
Nov 2018	46	33	46
Dec 2018	27	22	27
Total 2018	411	527	354
Jan 2019	25	34	52
Feb 2019	31	42	53
Mar 2019	26	31	25
Apr 2019	24	42	43
May 2019	30	30	34
Jun 2019	6	19	19
Jul 2019	6	22	34
Aug 2019	7	187	40
Sep 2019	16	127	43
Oct 2019	25	209	37
Nov 2019	15	28	38
Dec 2019	14	23	12
Total 2019	225	794	430
Jan 2020	22	37	22
Feb 2020	23	19	31
Mar 2020	18	15	30
Apr 2020	9	13	36
May 2020	33	25	60
Jun 2020	21	21	34
Jul 2020	14	16	29
Aug 2020	7	9	28
Sep 2020	20	35	33
Oct 2020	24	31	55
Nov 2020	24	37	37
Dec 2020	14	20	35
Total 2020	229	278	430
Jan 2021	24	35	35
Feb 2021	15	25	39
Total 2021	39	60	74
Total	12029	17185	12463