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ARTICLE, Cellular/Molecular

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos and Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: https://doi.org/10.1523/JNEUROSCI.22-05-01763.2002
Du Chu Wu
1Departments of Neurology and
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Vernice Jackson-Lewis
1Departments of Neurology and
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Miquel Vila
1Departments of Neurology and
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Kim Tieu
1Departments of Neurology and
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Peter Teismann
1Departments of Neurology and
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Caryn Vadseth
3Stokes Research Institute, Department of Pediatrics, Children's Hospital of Philadelphia, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
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Dong-Kug Choi
1Departments of Neurology and
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Harry Ischiropoulos
3Stokes Research Institute, Department of Pediatrics, Children's Hospital of Philadelphia, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
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Serge Przedborski
1Departments of Neurology and
2Pathology, Columbia University, New York, New York 10032, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-05-01763.2002
PubMed 
11880505
Published By 
Society for Neuroscience
History 
  • Received November 1, 2001
  • Revision received December 13, 2001
  • Accepted December 18, 2001
  • First published March 1, 2002.
  • Version of record published March 1, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Du Chu Wu1,
  2. Vernice Jackson-Lewis1,
  3. Miquel Vila1,
  4. Kim Tieu1,
  5. Peter Teismann1,
  6. Caryn Vadseth3,
  7. Dong-Kug Choi1,
  8. Harry Ischiropoulos3, and
  9. Serge Przedborski1,2
  1. 1Departments of Neurology and
  2. 2Pathology, Columbia University, New York, New York 10032, and
  3. 3Stokes Research Institute, Department of Pediatrics, Children's Hospital of Philadelphia, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
View Full Text

Author contributions

Disclosures

    • Received November 1, 2001.
    • Revision received December 13, 2001.
    • Accepted December 18, 2001.
  • This study was supported by National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke Grants R29 NS37345, RO1 NS38586, RO1 NS42269, and P50 NS38370, NIH/National Institute on Aging Grant RO1 AG13966, United States Department of Defense Grant DAMD 17-99-1-9471, the Lowenstein Foundation, the Lillian Goldman Charitable Trust, the Parkinson's Disease Foundation, the Muscular Dystrophy Association, the Amyotrophic Lateral Sclerosis (ALS) Association, and Project-ALS. M.V. is the recipient of a fellowship from the Human Frontier Science Program Organization, and P.T. is the recipient of German Research Foundation Grant TE 343/1-1.

  • Correspondence should be addressed to Dr. Serge Przedborski, Departments of Neurology and Pathology, BB-307, Columbia University, 650 West 168th Street, New York, NY 10032. E-mail: SP30{at}columbia.edu.

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The Journal of Neuroscience: 22 (5)
Journal of Neuroscience
Vol. 22, Issue 5
1 Mar 2002
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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos, Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: 10.1523/JNEUROSCI.22-05-01763.2002

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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos, Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: 10.1523/JNEUROSCI.22-05-01763.2002
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Keywords

  • IL-1β
  • iNOS
  • minocycline
  • microglia
  • MPTP
  • NADPH–oxidase
  • neurodegeneration
  • Parkinson's disease

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