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ARTICLE, Cellular/Molecular

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos and Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: https://doi.org/10.1523/JNEUROSCI.22-05-01763.2002
Du Chu Wu
1Departments of Neurology and
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Vernice Jackson-Lewis
1Departments of Neurology and
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Miquel Vila
1Departments of Neurology and
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Kim Tieu
1Departments of Neurology and
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Peter Teismann
1Departments of Neurology and
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Caryn Vadseth
3Stokes Research Institute, Department of Pediatrics, Children's Hospital of Philadelphia, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
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Dong-Kug Choi
1Departments of Neurology and
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Harry Ischiropoulos
3Stokes Research Institute, Department of Pediatrics, Children's Hospital of Philadelphia, and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
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Serge Przedborski
1Departments of Neurology and
2Pathology, Columbia University, New York, New York 10032, and
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The Journal of Neuroscience: 22 (5)
Journal of Neuroscience
Vol. 22, Issue 5
1 Mar 2002
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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos, Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: 10.1523/JNEUROSCI.22-05-01763.2002

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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Kim Tieu, Peter Teismann, Caryn Vadseth, Dong-Kug Choi, Harry Ischiropoulos, Serge Przedborski
Journal of Neuroscience 1 March 2002, 22 (5) 1763-1771; DOI: 10.1523/JNEUROSCI.22-05-01763.2002
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Keywords

  • IL-1β
  • iNOS
  • minocycline
  • microglia
  • MPTP
  • NADPH–oxidase
  • neurodegeneration
  • Parkinson's disease

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