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ARTICLE, Cellular/Molecular

Disease-Specific Human Glycine Receptor α1 Subunit Causes Hyperekplexia Phenotype and Impaired Glycine- and GABAA-Receptor Transmission in Transgenic Mice

Lore Becker, Jörg von Wegerer, Johannes Schenkel, Hanns-Ulrich Zeilhofer, Dieter Swandulla and Hans Weiher
Journal of Neuroscience 1 April 2002, 22 (7) 2505-2512; https://doi.org/10.1523/JNEUROSCI.22-07-02505.2002
Lore Becker
1Institut für Diabetesforschung, 80804 Munich, Germany,
2Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, 76021 Karlsruhe, Germany,
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Jörg von Wegerer
3Institut für Physiologie, Universität Bonn, 53111 Bonn, Germany, and
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Johannes Schenkel
2Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, 76021 Karlsruhe, Germany,
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Hanns-Ulrich Zeilhofer
4Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität Erlangen, 91054 Erlangen, Germany
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Dieter Swandulla
3Institut für Physiologie, Universität Bonn, 53111 Bonn, Germany, and
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Hans Weiher
1Institut für Diabetesforschung, 80804 Munich, Germany,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-07-02505.2002
PubMed 
11923415
Published By 
Society for Neuroscience
History 
  • Received August 6, 2001
  • Revision received November 29, 2001
  • Accepted December 19, 2001
  • First published April 1, 2002.
  • Version of record published April 1, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Lore Becker1,2,
  2. Jörg von Wegerer3,
  3. Johannes Schenkel2,
  4. Hanns-Ulrich Zeilhofer4,
  5. Dieter Swandulla3, and
  6. Hans Weiher1
  1. 1Institut für Diabetesforschung, 80804 Munich, Germany,
  2. 2Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, 76021 Karlsruhe, Germany,
  3. 3Institut für Physiologie, Universität Bonn, 53111 Bonn, Germany, and
  4. 4Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität Erlangen, 91054 Erlangen, Germany
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Author contributions

Disclosures

    • Received August 6, 2001.
    • Revision received November 29, 2001.
    • Accepted December 19, 2001.
  • This work was supported by grants from the Bundesministerium für Forschung und Bildung (H.W.), the Deutsche Forschungsgemeinschaft (D.S.), and the Fritz Thyssen Stiftung.

  • Correspondence should be addressed to Hans Weiher, Institut für Diabetesforschung, Kölner Platz 1, 80804 Munich, Germany. E-mail:hans.weiher{at}lrz.uni-muenchen.de.

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The Journal of Neuroscience: 22 (7)
Journal of Neuroscience
Vol. 22, Issue 7
1 Apr 2002
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Disease-Specific Human Glycine Receptor α1 Subunit Causes Hyperekplexia Phenotype and Impaired Glycine- and GABAA-Receptor Transmission in Transgenic Mice
Lore Becker, Jörg von Wegerer, Johannes Schenkel, Hanns-Ulrich Zeilhofer, Dieter Swandulla, Hans Weiher
Journal of Neuroscience 1 April 2002, 22 (7) 2505-2512; DOI: 10.1523/JNEUROSCI.22-07-02505.2002

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Disease-Specific Human Glycine Receptor α1 Subunit Causes Hyperekplexia Phenotype and Impaired Glycine- and GABAA-Receptor Transmission in Transgenic Mice
Lore Becker, Jörg von Wegerer, Johannes Schenkel, Hanns-Ulrich Zeilhofer, Dieter Swandulla, Hans Weiher
Journal of Neuroscience 1 April 2002, 22 (7) 2505-2512; DOI: 10.1523/JNEUROSCI.22-07-02505.2002
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Keywords

  • hyperekplexia
  • transgenic mouse model
  • neuromotor phenotype
  • glycine receptor
  • GABAA receptor
  • impaired postsynaptic inhibition

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