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ARTICLE, Development/Plasticity/Repair

Ectopic Expression in the Giant Fiber System ofDrosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity

Tanja A. Godenschwege, Julie H. Simpson, Xiaoliang Shan, Greg J. Bashaw, Corey S. Goodman and Rodney K. Murphey
Journal of Neuroscience 15 April 2002, 22 (8) 3117-3129; https://doi.org/10.1523/JNEUROSCI.22-08-03117.2002
Tanja A. Godenschwege
1Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, and
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Julie H. Simpson
2Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
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Xiaoliang Shan
1Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, and
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Greg J. Bashaw
2Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
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Corey S. Goodman
2Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
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Rodney K. Murphey
1Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.22-08-03117.2002
PubMed 
11943815
Published By 
Society for Neuroscience
History 
  • Received September 19, 2001
  • Revision received December 7, 2001
  • Accepted January 23, 2002
  • First published April 15, 2002.
  • Version of record published April 15, 2002.
Copyright & Usage 
Copyright © 2002 Society for Neuroscience

Author Information

  1. Tanja A. Godenschwege1,
  2. Julie H. Simpson2,
  3. Xiaoliang Shan1,
  4. Greg J. Bashaw2,
  5. Corey S. Goodman2, and
  6. Rodney K. Murphey1
  1. 1Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, and
  2. 2Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720
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Author contributions

Disclosures

    • Received September 19, 2001.
    • Revision received December 7, 2001.
    • Accepted January 23, 2002.
  • This work was supported by National Science Foundation Grant IBN9904957 to R.K.M., National Institutes of Health Grant NS18366, and Christopher Reeve Paralysis Foundation Grant GBC1–9801-2 to C.S.G. J.H.S. is a predoctoral fellow and C.S.G. is an investigator with the Howard Hughes Medical Institute. G.J.B. is a recipient of a Burroughs Wellcome Fund career award in the biomedical sciences. We thank Dr. A. Chiba for providing all UAS-comm fly lines, the Spyros Artavanis-Tsakonas laboratory for providing the anti-Slit antibody, and the J. Bacon and J. Davies laboratories for theshakB(lethal)-Gal4 line.

  • Correspondence should be addressed to Dr. Rodney K. Murphey, Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, MA 01003. E-mail: rmurphey{at}bio.umass.edu.

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The Journal of Neuroscience: 22 (8)
Journal of Neuroscience
Vol. 22, Issue 8
15 Apr 2002
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Ectopic Expression in the Giant Fiber System ofDrosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity
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Ectopic Expression in the Giant Fiber System ofDrosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity
Tanja A. Godenschwege, Julie H. Simpson, Xiaoliang Shan, Greg J. Bashaw, Corey S. Goodman, Rodney K. Murphey
Journal of Neuroscience 15 April 2002, 22 (8) 3117-3129; DOI: 10.1523/JNEUROSCI.22-08-03117.2002

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Ectopic Expression in the Giant Fiber System ofDrosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity
Tanja A. Godenschwege, Julie H. Simpson, Xiaoliang Shan, Greg J. Bashaw, Corey S. Goodman, Rodney K. Murphey
Journal of Neuroscience 15 April 2002, 22 (8) 3117-3129; DOI: 10.1523/JNEUROSCI.22-08-03117.2002
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Keywords

  • axon
  • dendrites
  • guidance
  • giant fiber
  • Drosophila
  • roundabout
  • Robo
  • Slit
  • synapse
  • commissureless

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