Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
ARTICLE, Development/Plasticity/Repair

Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring

Limin Shi, S. Hossein Fatemi, Robert W. Sidwell and Paul H. Patterson
Journal of Neuroscience 1 January 2003, 23 (1) 297-302; https://doi.org/10.1523/JNEUROSCI.23-01-00297.2003
Limin Shi
1Biology Division, California Institute of Technology, Pasadena, California 91125,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Hossein Fatemi
2Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert W. Sidwell
3Institute for Antiviral Research, Utah State University, Logan, Utah 84322
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul H. Patterson
1Biology Division, California Institute of Technology, Pasadena, California 91125,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in an animal model, we find that respiratory infection of pregnant mice (both BALB/c and C57BL/6 strains) with the human influenza virus yields offspring that display highly abnormal behavioral responses as adults. As in schizophrenia and autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle response. Compared with control mice, the infected mice also display striking responses to the acute administration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs. Moreover, these mice are deficient in exploratory behavior in both open-field and novel-object tests, and they are deficient in social interaction. At least some of these behavioral changes likely are attributable to the maternal immune response itself. That is, maternal injection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the absence of virus. Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus.

  • schizophrenia
  • autism
  • mental retardation
  • prepulse inhibition
  • acoustic startle
  • open field
  • novel object
  • clozapine
  • chlorpromazine
  • ketamine
  • poly(I:C)
View Full Text
Back to top

In this issue

The Journal of Neuroscience: 23 (1)
Journal of Neuroscience
Vol. 23, Issue 1
1 Jan 2003
  • Table of Contents
  • About the Cover
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
Limin Shi, S. Hossein Fatemi, Robert W. Sidwell, Paul H. Patterson
Journal of Neuroscience 1 January 2003, 23 (1) 297-302; DOI: 10.1523/JNEUROSCI.23-01-00297.2003

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
Limin Shi, S. Hossein Fatemi, Robert W. Sidwell, Paul H. Patterson
Journal of Neuroscience 1 January 2003, 23 (1) 297-302; DOI: 10.1523/JNEUROSCI.23-01-00297.2003
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • schizophrenia
  • autism
  • mental retardation
  • prepulse inhibition
  • acoustic startle
  • open field
  • novel object
  • clozapine
  • chlorpromazine
  • ketamine
  • poly(I:C)

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

ARTICLE

  • Emotion Processing in Chimeric Faces: Hemispheric Asymmetries in Expression and Recognition of Emotions
  • Gating of Hippocampal-Evoked Activity in Prefrontal Cortical Neurons by Inputs from the Mediodorsal Thalamus and Ventral Tegmental Area
  • Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol
Show more ARTICLE

Development/Plasticity/Repair

  • Change of spiny neuron structure in the basal ganglia song circuit and its regulation by miR-9 during song development
  • Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening
  • The epigenetic reader PHF23 is required for embryonic neurogenesis
Show more Development/Plasticity/Repair
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.