Quantitative Single-Cell Differences in μ-Opioid Receptor mRNA Distinguish Myelinated and Unmyelinated Nociceptors

The work was supported by grants from the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (E.W.M.), by the Medical Scientist Training Program at Washington University (S.C.S.), and by a predoctoral training grant from NIDA (D.W.B.). We thank David Grandy for providing the MOR cDNA; John Scott and Susan Amara for sharing molecular biology equipment; Susan Brust for making the drawing in Figure 1; Sean Cook, MacDonald Christie, Christina Lessov, and John Williams for giving helpful comments on this manuscript; and Lori Vaskalis for providing help with all illustrations.

Correspondence should be addressed to Dr. Ed McCleskey, Vollum Institute, Oregon Health and Science University, L-474, Portland, OR 97239. E-mail: mccleske{at}ohsu.edu.