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Cellular/Molecular

Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging

Oksana Berezovska, Pavan Ramdya, Jesse Skoch, Michael S. Wolfe, Brian J. Bacskai and Bradley T. Hyman
Journal of Neuroscience 1 June 2003, 23 (11) 4560-4566; https://doi.org/10.1523/JNEUROSCI.23-11-04560.2003
Oksana Berezovska
1 Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
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Pavan Ramdya
1 Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
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Jesse Skoch
1 Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
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Michael S. Wolfe
2 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115
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Brian J. Bacskai
1 Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
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Bradley T. Hyman
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-11-04560.2003
PubMed 
12805296
Published By 
Society for Neuroscience
History 
  • Received January 8, 2003
  • Revision received March 20, 2003
  • Accepted March 21, 2003
  • First published June 1, 2003.
  • Version of record published June 1, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/234560-07.00/0

Author Information

  1. Oksana Berezovska1,
  2. Pavan Ramdya1,
  3. Jesse Skoch1,
  4. Michael S. Wolfe2,
  5. Brian J. Bacskai1, and
  6. Bradley T. Hyman
  1. 1 Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
  2. 2 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115
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Author contributions

Disclosures

    • Received January 8, 2003.
    • Revision received March 20, 2003.
    • Accepted March 21, 2003.
  • This work was supported by National Institutes of Health Grants AG15379, AG 08487, EB00768, and NS 41355 (M.S.W.) and a Pioneer Award from the Alzheimer Association.

  • Correspondence should be addressed to Dr. Oksana Berezovska, 114 16th Street, Room 2750, Massachusetts General Hospital, Charlestown, MA 02129. E-mail: oberezovska{at}partners.org.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/234560-07$15.00/0

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The Journal of Neuroscience: 23 (11)
Journal of Neuroscience
Vol. 23, Issue 11
1 Jun 2003
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Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging
Oksana Berezovska, Pavan Ramdya, Jesse Skoch, Michael S. Wolfe, Brian J. Bacskai, Bradley T. Hyman
Journal of Neuroscience 1 June 2003, 23 (11) 4560-4566; DOI: 10.1523/JNEUROSCI.23-11-04560.2003

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Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging
Oksana Berezovska, Pavan Ramdya, Jesse Skoch, Michael S. Wolfe, Brian J. Bacskai, Bradley T. Hyman
Journal of Neuroscience 1 June 2003, 23 (11) 4560-4566; DOI: 10.1523/JNEUROSCI.23-11-04560.2003
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Keywords

  • APP
  • nicastrin
  • presenilin
  • γ-secretase
  • docking site
  • FLIM
  • spatial paradox

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