Figure 8. Changes in effective connectivity (psychophysiological interaction) with the movement-related activations. a, Areas showing positive PPI with left sensorimotor region of interest (x = -42, y = -26, z = 56) during movement-related activity after real-rTMS compared with sham-rTMS, displayed as described for Figure 7. b, Graphical representation illustrating the psychophysiological interactions between left sensorimotor region of interest (abscissa) and a proximate left sensorimotor region (x = -38, y = -20, z = 46). Regressions lines between the activity in the two regions have been fitted: sham-rTMS = S (squares) (r2 = 0.36, F = 25.68, gradient = 0.37) and real-rTMS = R (diamonds) (r2 = 0.79, F = 170.87, gradient = 0.71). c, Areas showing positive PPI with left premotor region of interest (x = -26, y = -14, z = 68), as described in Figure 7. d, Graphical representations illustrating the psychophysiological interactions between left premotor region of interest (abscissa) and left sensorimotor region (x = -36, y = -22, z = 44), as described for b. Sham-rTMS: r2 = 0.06, F = 2.66, gradient = 0.11; real-rTMS: r2 = 0.43, F = 34.13, gradient = 0.78. e, Areas showing positive PPI with the left SMA region of interest (x = -12, y = -4, z = 56), as described for Figure 7. f, Graphical representation illustrating the psychophysiological interactions between left SMA region of interest (abscissa) and left sensorimotor region (x = -30, y = -26, z = 54), as described for b. Sham-rTMS: r2 = 0.25, F = 15.52, gradient = 0.43; real-rTMS: r2 = 0.61, F = 71.0, gradient = 1.07.